KEGG   Homo sapiens (human): 6547Help
Entry
6547              CDS       T01001                                 

Gene name
SLC8A3, NCX3
Definition
(RefSeq) solute carrier family 8 member A3
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04740  Olfactory transduction
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa04974  Protein digestion and absorption
hsa04978  Mineral absorption
hsa05410  Hypertrophic cardiomyopathy (HCM)
hsa05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    6547 (SLC8A3)
   04020 Calcium signaling pathway
    6547 (SLC8A3)
   04022 cGMP-PKG signaling pathway
    6547 (SLC8A3)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    6547 (SLC8A3)
   04261 Adrenergic signaling in cardiomyocytes
    6547 (SLC8A3)
  09154 Digestive system
   04974 Protein digestion and absorption
    6547 (SLC8A3)
   04978 Mineral absorption
    6547 (SLC8A3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    6547 (SLC8A3)
  09157 Sensory system
   04740 Olfactory transduction
    6547 (SLC8A3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    6547 (SLC8A3)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    6547 (SLC8A3)
   05414 Dilated cardiomyopathy (DCM)
    6547 (SLC8A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6547 (SLC8A3)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6547 (SLC8A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   6547 (SLC8A3)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Haparin
  Others
   6547 (SLC8A3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Calx-beta Na_Ca_ex Na_Ca_ex_C
Motif
Other DBs
NCBI-GeneID: 6547
NCBI-ProteinID: NP_892114
OMIM: 607991
HGNC: 11070
Ensembl: ENSG00000100678
Vega: OTTHUMG00000152342
Pharos: P57103(Tbio)
UniProt: P57103
Position
14q24.2
AA seq 927 aa AA seqDB search
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL
GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG
CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW
SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA
TTWLFVSLWLLYILFATLEAYCYIKGF
NT seq 2784 nt NT seq  +upstreamnt  +downstreamnt
atggcgtggttaaggttgcagcctctcacctctgccttcctccattttgggctggttacc
tttgtgctcttcctgaatggtcttcgagcagaggctggtggctcaggggacgtgccaagc
acagggcagaacaatgagtcctgttcagggtcatcggactgcaaggagggtgtcatcctg
ccaatctggtacccggagaacccttcccttggggacaagattgccagggtcattgtctat
tttgtggccctgatatacatgttccttggggtgtccatcattgctgaccgcttcatggca
tctattgaagtcatcacctctcaagagagggaggtgacaattaagaaacccaatggagaa
accagcacaaccactattcgggtctggaatgaaactgtctccaacctgacccttatggcc
ctgggttcctctgctcctgagatactcctctctttaattgaggtgtgtggtcatgggttc
attgctggtgatctgggaccttctaccattgtagggagtgcagccttcaacatgttcatc
atcattggcatctgtgtctacgtgatcccagacggagagactcgcaagatcaagcatcta
cgagtcttcttcatcaccgctgcttggagtatctttgcctacatctggctctatatgatt
ctggcagtcttctcccctggtgtggtccaggtttgggaaggcctcctcactctcttcttc
tttccagtgtgtgtccttctggcctgggtggcagataaacgactgctcttctacaaatac
atgcacaaaaagtaccgcacagacaaacaccgaggaattatcatagagacagagggtgac
caccctaagggcattgagatggatgggaaaatgatgaattcccattttctagatgggaac
ctggtgcccctggaagggaaggaagtggatgagtcccgcagagagatgatccggattctc
aaggatctgaagcaaaaacacccagagaaggacttagatcagctggtggagatggccaat
tactatgctctttcccaccaacagaagagccgtgccttctaccgtatccaagccactcgt
atgatgactggtgcaggcaatatcctgaagaaacatgcagcagaacaagccaagaaggcc
tccagcatgagcgaggtgcacaccgatgagcctgaggactttatttccaaggtcttcttt
gacccatgttcttaccagtgcctggagaactgtggggctgtactcctgacagtggtgagg
aaagggggagacatgtcaaagaccatgtatgtggactacaaaacagaggatggttctgcc
aatgcaggggctgactatgagttcacagagggcacggtggttctgaagccaggagagacc
cagaaggagttctccgtgggcataattgatgacgacatttttgaggaggatgaacacttc
tttgtaaggttgagcaatgtccgcatagaggaggagcagccagaggaggggatgcctcca
gcaatattcaacagtcttcccttgcctcgggctgtcctagcctccccttgtgtggccaca
gttaccatcttggatgatgaccatgcaggcatcttcacttttgaatgtgatactattcat
gtcagtgagagtattggtgttatggaggtcaaggttctgcggacatcaggtgcccggggt
acagtcatcgtcccctttaggacagtagaagggacagccaagggtggcggtgaggacttt
gaagacacatatggggagttggaattcaagaatgatgaaactgtgaaaaccataagggtt
aaaatagtagatgaggaggaatacgaaaggcaagagaatttcttcattgcccttggtgaa
ccgaaatggatggaacgtggaatatcagcgctcctgttatctccagatgtgacagacagg
aagctgactatggaagaagaggaggccaagaggatagcagagatgggaaagccagtattg
ggtgaacaccccaaactagaagtcatcattgaagagtcctatgagttcaagactacggtg
gacaaactgatcaagaagacaaacctggccttggttgtggggacccattcctggagggac
cagttcatggaggccatcaccgtcagtgcagcaggggatgaggatgaggatgaatccggg
gaggagaggctgccctcctgctttgactacgtcatgcacttcctgactgtcttctggaag
gtgctgtttgcctgtgtgccccccacagagtactgccacggctgggcctgcttcgccgtc
tccatcctcatcattggcatgctcaccgccatcattggggacctggcctcgcacttcggc
tgcaccattggtctcaaagattcagtcacagctgttgttttcgtggcatttggcacctct
gtcccagatacgtttgccagcaaagctgctgccctccaggatgtatatgcagacgcctcc
attggcaacgtgacgggcagcaacgccgtcaatgtcttcctgggcatcggcctggcctgg
tccgtggccgccatctactgggctctgcagggacaggagttccacgtgtcggccggcaca
ctggccttctccgtcaccctcttcaccatctttgcatttgtctgcatcagcgtgctcttg
taccgaaggcggccgcacctgggaggggagcttggtggcccccgtggctgcaagctcgcc
acaacatggctctttgtgagcctgtggctcctctacatactctttgccacactagaggcc
tattgctacatcaaggggttctaa

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