KEGG   Homo sapiens (human): 6550
Entry
6550              CDS       T01001                                 

Gene name
SLC9A3, DIAR8, NHE-3, NHE3
Definition
(RefSeq) solute carrier family 9 member A3
  KO
K12040  solute carrier family 9 (sodium/hydrogen exchanger), member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04964  Proximal tubule bicarbonate reclamation
hsa04974  Protein digestion and absorption
hsa04976  Bile secretion
hsa04978  Mineral absorption
Disease
H01174  Congenital diarrhea
Drug target
Tenapanor (DG03072): D11652 D11653<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    6550 (SLC9A3)
   04974 Protein digestion and absorption
    6550 (SLC9A3)
   04978 Mineral absorption
    6550 (SLC9A3)
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    6550 (SLC9A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6550 (SLC9A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC9: Na+/H+ exchanger
   6550 (SLC9A3)
SSDB
Motif
Pfam: Na_H_Exchanger NEXCaM_BD
Other DBs
NCBI-GeneID: 6550
NCBI-ProteinID: NP_004165
OMIM: 182307
HGNC: 11073
Ensembl: ENSG00000066230
Vega: OTTHUMG00000090315
Pharos: P48764(Tbio)
UniProt: P48764
Position
5p15.33
AA seq 834 aa
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
NT seq 2505 nt   +upstreamnt  +downstreamnt
atgtggggactcggggcccggggccccgaccgggggctgctgctggcgctggcgctgggc
gggctggcgcgggccgggggcgtcgaggtggagcccggcggcgcgcacggcgagagcggg
ggcttccaggtggtcaccttcgagtgggcccacgtgcaggatccctacgtcatcgcgctc
tggatcctcgtggccagcttggccaagatcgggttccacctgtcccacaaggtcaccagc
gtggttcccgagagcgccctgctcatcgtgctgggcctggtgctgggcggcatcgtctgg
gcggccgaccacatcgcgtccttcacactgacgcccaccgtcttcttcttctacctgctg
ccccccatcgtgctggacgccggctacttcatgcccaaccgcctcttcttcggcaacctg
gggaccatcctgttgtacgccgtcgtgggtaccgtgtggaacgcggccaccaccgggctg
tccctctacggcgtcttcctcagtgggctcatgggcgacctgcagattgggctgctggac
ttcctcctgtttggcagcctcatggcggctgtggacccggtggccgtcctggccgtgttt
gaggaggtccatgtcaacgaggtcctgttcatcatcgtcttcggggagtcgctgctgaac
gacgcagtcaccgtggttctgtacaatgtgtttgaatctttcgtggcgctgggaggtgac
aacgtgactggcgtggactgcgtgaagggcatagtgtccttcttcgtggtgagcctgggg
ggcacgctggtgggggtggtcttcgccttcctgctgtcgctggtgacgcgcttcaccaag
catgtgcgtatcatcgagcccggcttcgtgttcatcatctcctacctgtcctacctgacg
tccgagatgctgtcgctgtcggccatcctcgccatcaccttctgtggcatctgctgtcag
aagtatgtgaaggccaacatctcggagcagtcggccaccaccgtgcgctacaccatgaag
atgctggccagcagcgccgagaccatcatcttcatgttcctgggtatctcggccgtgaac
ccgttcatctggacctggaacacggccttcgtgctcctgacgctggtcttcatctccgtg
taccgggccatcggtgtggtcctgcagacctggcttctgaaccgctaccgcatggtgcag
ctggagcccattgaccaggtggtcctgtcctacgggggcctgcgcggggccgtggccttt
gccctggtggtgcttctggatggagacaaggtcaaggagaagaacctgttcgtcagcacc
accatcatcgtagtgttcttcaccgtcatcttccagggcctgaccatcaagcctctggtg
cagtggctgaaggtgaagaggagcgagcaccgggaacctcggctcaacgagaagctgcac
gggcgcgctttcgaccacatcctctcggccatcgaggacatatccggacagatcgggcac
aattatctcagagacaagtggtcccacttcgacaggaagttcctcagcagggtcctcatg
agacggtcggcccagaagtctcgagaccggatcctgaatgtcttccacgagctgaacctg
aaggatgccatcagctacgtggctgagggagagcgccgcgggtccctggccttcatccgc
tcccccagcaccgacaacgtggtcaacgtggacttcacgccacgatcgtccaccgtggag
gcctctgtctcctacctcctgagagaaaatgtcagcgctgtctgcctggacatgcagtct
ctggagcagcgacggcggagcatccgggacgcggaggacatggtcacgcaccacacgcta
cagcagtacctgtacaagccgcggcaggagtacaagcatctgtacagccgacacgagctc
acgcccacggaggacgagaaacaggaccgggaaatcttccacaggaccatgcggaagcgc
ctggagtccttcaagtcgaccaagctggggctcaaccagaacaagaaggcggccaagctg
tacaagcgggagcgtgcccagaagcggagaaacagcagcatccccaatgggaagctgccc
atggagagccctgcgcagaatttcaccatcaaggagaaagacttggaactttcagacacc
gaggagccccccaactatgatgaggagatgagtggggggatcgagttcctggctagtgtc
accaaggacacagcgtccgactcccctgcaggaattgacaaccctgtgttttctccggac
gaggccctggaccgcagcctcctggccaggctgccgccctggctgtctcccggggagacg
gtggtcccctcgcagagggcccgcacgcagattccctactctcccggcaccttctgccgc
ctgatgcccttccgcctcagcagcaagtccgtggactccttcctgcaggcagacggcccc
gaggagcggccccccgccgccctccccgagtccacacacatgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (16)   
   RefSeq(nuc) (2)   
   GenBank (7)   
   EMBL (7)   
Protein domain (2)   
   Pfam (2)   
All databases (50)   

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