KEGG   Homo sapiens (human): 6622
Entry
6622              CDS       T01001                                 

Gene name
SNCA, NACP, PARK1, PARK4, PD1
Definition
(RefSeq) synuclein alpha
  KO
K04528  alpha-synuclein
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06410  Calcium signaling
nt06412  Unfolded protein response (UPR) signaling
nt06418  Oxidative phosphorylation
nt06419  Microtubule-based transport
nt06420  Ubiquitin-proteasome system
nt06422  Dopamine metabolism
nt06463  Parkinson disease
  Element
N01019  Parkin-mediated ubiquitination
N01020  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01031  Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01033  Mutation-caused aberrant SNCA to ATF6-mediated transcription
N01034  Mutation-caused aberrant SNCA to IRE1a-XBP1 signaling pathway
N01035  Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
N01037  Mutation-caused aberrant SNCA to L-DOPA generation
N01041  Mutation-caused aberrant SNCA to transport of dopamine
N01042  Mutation-caused aberrant SNCA to electron transfer in Complex I
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
Disease
H00057  Parkinson disease
H00066  Lewy body dementia (LBD)
H01600  Parkinsonian syndrome
Drug target
Cinpanemab: D11467
Prasinezumab: D11420
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    6622 (SNCA)
   05012 Parkinson disease
    6622 (SNCA)
   05022 Pathways of neurodegeneration - multiple diseases
    6622 (SNCA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    6622 (SNCA)
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6622 (SNCA)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Others
    6622 (SNCA)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   6622 (SNCA)
SSDB
Motif
Pfam: Synuclein
Other DBs
NCBI-GeneID: 6622
NCBI-ProteinID: NP_000336
OMIM: 163890
HGNC: 11138
Ensembl: ENSG00000145335
Vega: OTTHUMG00000130948
Pharos: P37840(Tchem)
UniProt: P37840
Structure
PDB: 

Position
4q22.1
AA seq 140 aa
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP
DNEAYEMPSEEGYQDYEPEA
NT seq 423 nt   +upstreamnt  +downstreamnt
atggatgtattcatgaaaggactttcaaaggccaaggagggagttgtggctgctgctgag
aaaaccaaacagggtgtggcagaagcagcaggaaagacaaaagagggtgttctctatgta
ggctccaaaaccaaggagggagtggtgcatggtgtggcaacagtggctgagaagaccaaa
gagcaagtgacaaatgttggaggagcagtggtgacgggtgtgacagcagtagcccagaag
acagtggagggagcagggagcattgcagcagccactggctttgtcaaaaaggaccagttg
ggcaagaatgaagaaggagccccacaggaaggaattctggaagatatgcctgtggatcct
gacaatgaggcttatgaaatgccttctgaggaagggtatcaagactacgaacctgaagcc
taa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (11)   
   KEGG NETWORK (11)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (74)   
   RefSeq(nuc) (18)   
   GenBank (28)   
   EMBL (28)   
Protein domain (1)   
   Pfam (1)   
All databases (134)   

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