KEGG   Homo sapiens (human): 6647Help
Entry
6647              CDS       T01001                                 

Gene name
SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP, hSod1, homodimer
Definition
(RefSeq) superoxide dismutase 1
  KO
K04565  superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04146  Peroxisome
hsa04213  Longevity regulating pathway - multiple species
hsa05014  Amyotrophic lateral sclerosis (ALS)
hsa05016  Huntington disease
hsa05020  Prion diseases
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    6647 (SOD1)
 09150 Organismal Systems
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    6647 (SOD1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis (ALS)
    6647 (SOD1)
   05016 Huntington disease
    6647 (SOD1)
   05020 Prion diseases
    6647 (SOD1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.15  Acting on superoxide as acceptor
   1.15.1  Acting on superoxide as acceptor (only sub-subclass identified to date)
    1.15.1.1  superoxide dismutase
     6647 (SOD1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Sod_Cu
Motif
Other DBs
NCBI-GeneID: 6647
NCBI-ProteinID: NP_000445
OMIM: 147450
HGNC: 11179
Ensembl: ENSG00000142168
Vega: OTTHUMG00000084878
Pharos: P00441(Tbio)
UniProt: P00441 V9HWC9
Structure
PDB: 

Position
21q22.11
AA seq 154 aa AA seqDB search
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
NT seq 465 nt NT seq  +upstreamnt  +downstreamnt
atggcgacgaaggccgtgtgcgtgctgaagggcgacggcccagtgcagggcatcatcaat
ttcgagcagaaggaaagtaatggaccagtgaaggtgtggggaagcattaaaggactgact
gaaggcctgcatggattccatgttcatgagtttggagataatacagcaggctgtaccagt
gcaggtcctcactttaatcctctatccagaaaacacggtgggccaaaggatgaagagagg
catgttggagacttgggcaatgtgactgctgacaaagatggtgtggccgatgtgtctatt
gaagattctgtgatctcactctcaggagaccattgcatcattggccgcacactggtggtc
catgaaaaagcagatgacttgggcaaaggtggaaatgaagaaagtacaaagacaggaaac
gctggaagtcgtttggcttgtggtgtaattgggatcgcccaataa

KEGG   Homo sapiens (human): 6648Help
Entry
6648              CDS       T01001                                 

Gene name
SOD2, IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD
Definition
(RefSeq) superoxide dismutase 2
  KO
K04564  superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04146  Peroxisome
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa05016  Huntington disease
Disease
H01456  Diabetic nephropathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    6648 (SOD2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    6648 (SOD2)
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    6648 (SOD2)
   04213 Longevity regulating pathway - multiple species
    6648 (SOD2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    6648 (SOD2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.15  Acting on superoxide as acceptor
   1.15.1  Acting on superoxide as acceptor (only sub-subclass identified to date)
    1.15.1.1  superoxide dismutase
     6648 (SOD2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Sod_Fe_C Sod_Fe_N
Motif
Other DBs
NCBI-GeneID: 6648
NCBI-ProteinID: NP_000627
OMIM: 147460
HGNC: 11180
Ensembl: ENSG00000112096 ENSG00000285441
Vega: OTTHUMG00000015940
Pharos: P04179(Tbio)
UniProt: P04179 A0A384NL29
Structure
PDB: 

Position
6q25.3
AA seq 222 aa AA seqDB search
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
NT seq 669 nt NT seq  +upstreamnt  +downstreamnt
atgttgagccgggcagtgtgcggcaccagcaggcagctggctccggttttggggtatctg
ggctccaggcagaagcacagcctccccgacctgccctacgactacggcgccctggaacct
cacatcaacgcgcagatcatgcagctgcaccacagcaagcaccacgcggcctacgtgaac
aacctgaacgtcaccgaggagaagtaccaggaggcgttggccaagggagatgttacagcc
cagatagctcttcagcctgcactgaagttcaatggtggtggtcatatcaatcatagcatt
ttctggacaaacctcagccctaacggtggtggagaacccaaaggggagttgctggaagcc
atcaaacgtgactttggttcctttgacaagtttaaggagaagctgacggctgcatctgtt
ggtgtccaaggctcaggttggggttggcttggtttcaataaggaacggggacacttacaa
attgctgcttgtccaaatcaggatccactgcaaggaacaacaggccttattccactgctg
gggattgatgtgtgggagcacgcttactaccttcagtataaaaatgtcaggcctgattat
ctaaaagctatttggaatgtaatcaactgggagaatgtaactgaaagatacatggcttgc
aaaaagtaa

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