KEGG   Homo sapiens (human): 6688
Entry
6688              CDS       T01001                                 

Gene name
SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A
Definition
(RefSeq) Spi-1 proto-oncogene
  KO
K09438  transcription factor PU.1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04380  Osteoclast differentiation
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Network
nt06240  Transcription
nt06275  Acute myeloid leukemia
  Element
N00112  AML1-ETO fusion to PU.1-mediated transcription
Disease
H00003  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    6688 (SPI1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6688 (SPI1)
   05202 Transcriptional misregulation in cancer
    6688 (SPI1)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    6688 (SPI1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    6688 (SPI1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6688 (SPI1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Tryptophan clusters Ets-type
    6688 (SPI1)
SSDB
Motif
Pfam: Ets
Other DBs
NCBI-GeneID: 6688
NCBI-ProteinID: NP_003111
OMIM: 165170
HGNC: 11241
Ensembl: ENSG00000066336
Vega: OTTHUMG00000150150
Pharos: P17947(Tbio)
UniProt: P17947
Position
11p11.2
AA seq 270 aa
MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHS
EFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQ
YPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLL
RSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGE
VKKVKKKLTYQFSGEVLGRGGLAERRHPPH
NT seq 813 nt   +upstreamnt  +downstreamnt
atgttacaggcgtgcaaaatggaagggtttcccctcgtcccccctccatcagaagacctg
gtgccctatgacacggatctataccaacgccaaacgcacgagtattacccctatctcagc
agtgatggggagagccatagcgaccattactgggacttccacccccaccacgtgcacagc
gagttcgagagcttcgccgagaacaacttcacggagctccagagcgtgcagcccccgcag
ctgcagcagctctaccgccacatggagctggagcagatgcacgtcctcgatacccccatg
gtgccaccccatcccagtcttggccaccaggtctcctacctgccccggatgtgcctccag
tacccatccctgtccccagcccagcccagctcagatgaggaggagggcgagcggcagagc
cccccactggaggtgtctgacggcgaggcggatggcctggagcccgggcctgggctcctg
cctggggagacaggcagcaagaagaagatccgcctgtaccagttcctgttggacctgctc
cgcagcggcgacatgaaggacagcatctggtgggtggacaaggacaagggcaccttccag
ttctcgtccaagcacaaggaggcgctggcgcaccgctggggcatccagaagggcaaccgc
aagaagatgacctaccagaagatggcgcgcgcgctgcgcaactacggcaagacgggcgag
gtcaagaaggtgaagaagaagctcacctaccagttcagcggcgaagtgctgggccgcggg
ggcctggccgagcggcgccacccgccccactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (1)   
   KEGG NETWORK (1)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (18)   
   RefSeq(nuc) (4)   
   GenBank (7)   
   EMBL (7)   
Protein domain (1)   
   Pfam (1)   
All databases (50)   

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