KEGG   Homo sapiens (human): 6692
Entry
6692              CDS       T01001                                 
Symbol
SPINT1, HAI, HAI1, MANSC2
Name
(RefSeq) serine peptidase inhibitor, Kunitz type 1
  KO
K15619  Kunitz-type protease inhibitor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05202  Transcriptional misregulation in cancer
hsa05215  Prostate cancer
Network
nt06240  Transcription (cancer)
nt06272  Prostate cancer
  Element
N00129  TMPRSS2-ERG fusion to transcriptional repression
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    6692 (SPINT1)
  09162 Cancer: specific types
   05215 Prostate cancer
    6692 (SPINT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    6692 (SPINT1)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   6692 (SPINT1)
SSDB
Motif
Pfam: Kunitz_BPTI MANEC K319L-like_PKD Ldl_recept_a Chordopox_A13L Antimicrobial12
Other DBs
NCBI-GeneID: 6692
NCBI-ProteinID: NP_857593
OMIM: 605123
HGNC: 11246
Ensembl: ENSG00000166145
UniProt: O43278
Structure
Position
15:40844048..40858207
AA seq 529 aa
MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
RGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
NT seq 1590 nt   +upstreamnt  +downstreamnt
atggcccctgcgaggacgatggcccgcgcccgcctcgccccggccggcatccctgccgtc
gccttgtggcttctgtgcacgctcggcctccagggcacccaggccgggccaccgcccgcg
ccccctgggctgcccgcgggagccgactgcctgaacagctttaccgccggggtgcctggc
ttcgtgctggacaccaacgcctcggtcagcaacggagctaccttcctggagtcccccacc
gtgcgccggggctgggactgcgtgcgcgcctgctgcaccacccagaactgcaacttggcg
ctagtggagctgcagcccgaccgcggggaggacgccatcgccgcctgcttcctcatcaac
tgcctctacgagcagaacttcgtgtgcaagttcgcgcccagggagggcttcatcaactac
ctcacgagggaagtgtaccgctcctaccgccagctgcggacccagggctttggagggtct
gggatccccaaggcctgggcaggcatagacttgaaggtacaaccccaggaacccctggtg
ctgaaggatgtggaaaacacagattggcgcctactgcggggtgacacggatgtcagggta
gagaggaaagacccaaaccaggtggaactgtggggactcaaggaaggcacctacctgttc
cagctgacagtgactagctcagaccacccagaggacacggccaacgtcacagtcactgtg
ctgtccaccaagcagacagaagactactgcctcgcatccaacaaggtgggtcgctgccgg
ggctctttcccacgctggtactatgaccccacggagcagatctgcaagagtttcgtttat
ggaggctgcttgggcaacaagaacaactaccttcgggaagaagagtgcattctagcctgt
cggggtgtgcaaggtgggcctttgagaggcagctctggggctcaggcgactttcccccag
ggcccctccatggaaaggcgccatccagtgtgctctggcacctgtcagcccacccagttc
cgctgcagcaatggctgctgcatcgacagtttcctggagtgtgacgacacccccaactgc
cccgacgcctccgacgaggctgcctgtgaaaaatacacgagtggctttgacgagctccag
cgcatccatttccccagtgacaaagggcactgcgtggacctgccagacacaggactctgc
aaggagagcatcccgcgctggtactacaaccccttcagcgaacactgcgcccgctttacc
tatggtggttgttacggcaacaagaacaactttgaggaagagcagcagtgcctcgagtct
tgtcgcggcatctccaagaaggatgtgtttggcctgaggcgggaaatccccattcccagc
acaggctctgtggagatggctgtcgcagtgttcctggtcatctgcattgtggtggtggta
gccatcttgggttactgcttcttcaagaaccagagaaaggacttccacggacaccaccac
cacccaccacccacccctgccagctccactgtctccactaccgaggacacggagcacctg
gtctataaccacaccacgcggcccctctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (22)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (36)   
   RefSeq(nuc) (12)   
   GenBank (12)   
   EMBL (12)   
3D Structure (7)   
   PDB (7)   
Protein domain (6)   
   Pfam (6)   
All databases (86)   

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