KEGG   Homo sapiens (human): 6692
Entry
6692              CDS       T01001                                 
Symbol
SPINT1, HAI, HAI1, MANSC2
Name
(RefSeq) serine peptidase inhibitor, Kunitz type 1
  KO
K15619  Kunitz-type protease inhibitor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05202  Transcriptional misregulation in cancer
hsa05215  Prostate cancer
Network
nt06240  Transcription
nt06272  Prostate cancer
  Element
N00129  TMPRSS2-ERG fusion to transcriptional repression
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    6692 (SPINT1)
  09162 Cancer: specific types
   05215 Prostate cancer
    6692 (SPINT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    6692 (SPINT1)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   6692 (SPINT1)
SSDB
Motif
Pfam: Kunitz_BPTI MANEC Ldl_recept_a Chordopox_A13L Antimicrobial12
Other DBs
NCBI-GeneID: 6692
NCBI-ProteinID: NP_857593
OMIM: 605123
HGNC: 11246
Ensembl: ENSG00000166145
UniProt: O43278
Structure
Position
15:40844048..40858207
AA seq 529 aa
MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
RGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
NT seq 1590 nt   +upstreamnt  +downstreamnt
atggcccctgcgaggacgatggcccgcgcccgcctcgccccggccggcatccctgccgtc
gccttgtggcttctgtgcacgctcggcctccagggcacccaggccgggccaccgcccgcg
ccccctgggctgcccgcgggagccgactgcctgaacagctttaccgccggggtgcctggc
ttcgtgctggacaccaacgcctcggtcagcaacggagctaccttcctggagtcccccacc
gtgcgccggggctgggactgcgtgcgcgcctgctgcaccacccagaactgcaacttggcg
ctagtggagctgcagcccgaccgcggggaggacgccatcgccgcctgcttcctcatcaac
tgcctctacgagcagaacttcgtgtgcaagttcgcgcccagggagggcttcatcaactac
ctcacgagggaagtgtaccgctcctaccgccagctgcggacccagggctttggagggtct
gggatccccaaggcctgggcaggcatagacttgaaggtacaaccccaggaacccctggtg
ctgaaggatgtggaaaacacagattggcgcctactgcggggtgacacggatgtcagggta
gagaggaaagacccaaaccaggtggaactgtggggactcaaggaaggcacctacctgttc
cagctgacagtgactagctcagaccacccagaggacacggccaacgtcacagtcactgtg
ctgtccaccaagcagacagaagactactgcctcgcatccaacaaggtgggtcgctgccgg
ggctctttcccacgctggtactatgaccccacggagcagatctgcaagagtttcgtttat
ggaggctgcttgggcaacaagaacaactaccttcgggaagaagagtgcattctagcctgt
cggggtgtgcaaggtgggcctttgagaggcagctctggggctcaggcgactttcccccag
ggcccctccatggaaaggcgccatccagtgtgctctggcacctgtcagcccacccagttc
cgctgcagcaatggctgctgcatcgacagtttcctggagtgtgacgacacccccaactgc
cccgacgcctccgacgaggctgcctgtgaaaaatacacgagtggctttgacgagctccag
cgcatccatttccccagtgacaaagggcactgcgtggacctgccagacacaggactctgc
aaggagagcatcccgcgctggtactacaaccccttcagcgaacactgcgcccgctttacc
tatggtggttgttacggcaacaagaacaactttgaggaagagcagcagtgcctcgagtct
tgtcgcggcatctccaagaaggatgtgtttggcctgaggcgggaaatccccattcccagc
acaggctctgtggagatggctgtcgcagtgttcctggtcatctgcattgtggtggtggta
gccatcttgggttactgcttcttcaagaaccagagaaaggacttccacggacaccaccac
cacccaccacccacccctgccagctccactgtctccactaccgaggacacggagcacctg
gtctataaccacaccacgcggcccctctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (36)   
   RefSeq(nuc) (12)   
   GenBank (12)   
   EMBL (12)   
3D Structure (7)   
   PDB (7)   
Protein domain (5)   
   Pfam (5)   
All databases (92)   

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