KEGG   Homo sapiens (human): 6723Help
Entry
6723              CDS       T01001                                 

Gene name
SRM, PAPT, SPDSY, SPS1, SRML1
Definition
(RefSeq) spermidine synthase
  KO
K00797  spermidine synthase [EC:2.5.1.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa00330  Arginine and proline metabolism
hsa00410  beta-Alanine metabolism
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
Module
hsa_M00034  Methionine salvage pathway
hsa_M00133  Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    6723 (SRM)
   00330 Arginine and proline metabolism
    6723 (SRM)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    6723 (SRM)
   00480 Glutathione metabolism
    6723 (SRM)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.16  spermidine synthase
     6723 (SRM)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Spermine_synth Spermine_synt_N Methyltransf_31 Methyltransf_25 Methyltransf_30
Motif
Other DBs
NCBI-GeneID: 6723
NCBI-ProteinID: NP_003123
OMIM: 182891
HGNC: 11296
Ensembl: ENSG00000116649
Vega: OTTHUMG00000002119
Pharos: P19623(Tchem)
UniProt: P19623
Structure
PDB: 

Position
1p36.22
AA seq 302 aa AA seqDB search
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG
NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV
VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP
AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT
YPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND
VS
NT seq 909 nt NT seq  +upstreamnt  +downstreamnt
atggagcccggccccgacggccccgccgcctccggccccgccgccatccgcgagggctgg
ttccgcgagacctgcagcctgtggcccggccaggccctgtcactgcaggtggagcagctg
ctccaccaccggcgctcgcgctaccaggacatcctcgtcttccgcagtaagacctatggc
aacgtgctggtgttggacggtgtcatccagtgcacggagagagacgagttctcctaccag
gagatgatcgccaacctgcctctctgcagccaccccaacccgcgaaaggtgctgatcatc
gggggcggagatggaggtgtcctgcgggaggtggtgaagcacccctccgtggagtccgtg
gtccagtgtgagatcgacgaggatgtcatccaagtctccaagaagttcctgccaggcatg
gccattggctactctagctcgaagctgaccctacatgtgggtgacggttttgagttcatg
aaacagaatcaggatgccttcgacgtgatcatcactgactcctcagaccccatgggcccc
gccgaaagtctcttcaaggagtcctattaccagctcatgaagacagccctcaaggaagat
ggtgtcctctgctgccagggcgagtgccagtggctgcacctggacctcatcaaggagatg
cggcagttctgccagtccctgttccccgtggtggcctatgcctactgcaccatccccacc
taccccagcggccagatcggcttcatgctgtgcagcaagaacccgagcacgaacttccag
gagccggtgcagccgctgacacagcagcaggtggcgcagatgcagctgaagtactacaac
tccgacgtgcaccgcgccgcctttgtgctgcccgagtttgcccgcaaggccctgaatgat
gtgagctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
Protein domain (5)   
   Pfam (5)   
All databases (55)   

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