KEGG   Homo sapiens (human): 6768
Entry
6768              CDS       T01001                                 
Symbol
ST14, ARCI11, CAP3, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
Name
(RefSeq) ST14 transmembrane serine protease matriptase
  KO
K08670  suppressor of tumorigenicity protein 14 [EC:3.4.21.109]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
hsa05206  MicroRNAs in cancer
Network
nt06545  Cornified envelope formation
  Element
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Disease
H00734  Autosomal recessive congenital ichthyosis
H00739  Ichthyosis with hypotrichosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    6768 (ST14)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    6768 (ST14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    6768 (ST14)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.109  matriptase
     6768 (ST14)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   6768 (ST14)
SSDB
Motif
Pfam: Trypsin CUB Ldl_recept_a SEA CUB_2 DUF1986 CDCP1_CUB_6
Other DBs
NCBI-GeneID: 6768
NCBI-ProteinID: NP_068813
OMIM: 606797
HGNC: 11344
Ensembl: ENSG00000149418
UniProt: Q9Y5Y6
Structure
Position
11:130159782..130210362
AA seq 855 aa
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
NT seq 2568 nt   +upstreamnt  +downstreamnt
atggggagcgatcgggcccgcaagggcggagggggcccgaaggacttcggcgcgggactc
aagtacaactcccggcacgagaaagtgaatggcttggaggaaggcgtggagttcctgcca
gtcaacaacgtcaagaaggtggaaaagcatggcccggggcgctgggtggtgctggcagcc
gtgctgatcggcctcctcttggtcttgctggggatcggcttcctggtgtggcatttgcag
taccgggacgtgcgtgtccagaaggtcttcaatggctacatgaggatcacaaatgagaat
tttgtggatgcctacgagaactccaactccactgagtttgtaagcctggccagcaaggtg
aaggacgcgctgaagctgctgtacagcggagtcccattcctgggcccctaccacaaggag
tcggctgtgacggccttcagcgagggcagcgtcatcgcctactactggtctgagttcagc
atcccgcagcacctggtggaggaggccgagcgcgtcatggccgaggagcgcgtagtcatg
ctgcccccgcgggcgcgctccctgaagtcctttgtggtcacctcagtggtggctttcccc
acggactccaaaacagtacagaggacccaggacaacagctgcagctttggcctgcacgcc
cgcggtgtggagctgatgcgcttcaccacgcccggcttccctgacagcccctaccccgct
catgcccgctgccagtgggccctgcggggggacgccgactcagtgctgagcctcaccttc
cgcagctttgaccttgcgtcctgcgacgagcgcggcagcgacctggtgacggtgtacaac
accctgagccccatggagccccacgccctggtgcagttgtgtggcacctaccctccctcc
tacaacctgaccttccactcctcccagaacgtcctgctcatcacactgataaccaacact
gagcggcggcatcccggctttgaggccaccttcttccagctgcctaggatgagcagctgt
ggaggccgcttacgtaaagcccaggggacattcaacagcccctactacccaggccactac
ccacccaacattgactgcacatggaacattgaggtgcccaacaaccagcatgtgaaggtg
cgcttcaaattcttctacctgctggagcccggcgtgcctgcgggcacctgccccaaggac
tacgtggagatcaacggggagaaatactgcggagagaggtcccagttcgtcgtcaccagc
aacagcaacaagatcacagttcgcttccactcagatcagtcctacaccgacaccggcttc
ttagctgaatacctctcctacgactccagtgacccatgcccggggcagttcacgtgccgc
acggggcggtgtatccggaaggagctgcgctgtgatggctgggccgactgcaccgaccac
agcgatgagctcaactgcagttgcgacgccggccaccagttcacgtgcaagaacaagttc
tgcaagcccctcttctgggtctgcgacagtgtgaacgactgcggagacaacagcgacgag
caggggtgcagttgtccggcccagaccttcaggtgttccaatgggaagtgcctctcgaaa
agccagcagtgcaatgggaaggacgactgtggggacgggtccgacgaggcctcctgcccc
aaggtgaacgtcgtcacttgtaccaaacacacctaccgctgcctcaatgggctctgcttg
agcaagggcaaccctgagtgtgacgggaaggaggactgtagcgacggctcagatgagaag
gactgcgactgtgggctgcggtcattcacgagacaggctcgtgttgttgggggcacggat
gcggatgagggcgagtggccctggcaggtaagcctgcatgctctgggccagggccacatc
tgcggtgcttccctcatctctcccaactggctggtctctgccgcacactgctacatcgat
gacagaggattcaggtactcagaccccacgcagtggacggccttcctgggcttgcacgac
cagagccagcgcagcgcccctggggtgcaggagcgcaggctcaagcgcatcatctcccac
cccttcttcaatgacttcaccttcgactatgacatcgcgctgctggagctggagaaaccg
gcagagtacagctccatggtgcggcccatctgcctgccggacgcctcccatgtcttccct
gccggcaaggccatctgggtcacgggctggggacacacccagtatggaggcactggcgcg
ctgatcctgcaaaagggtgagatccgcgtcatcaaccagaccacctgcgagaacctcctg
ccgcagcagatcacgccgcgcatgatgtgcgtgggcttcctcagcggcggcgtggactcc
tgccagggtgattccgggggacccctgtccagcgtggaggcggatgggcggatcttccag
gccggtgtggtgagctggggagacggctgcgctcagaggaacaagccaggcgtgtacaca
aggctccctctgtttcgggactggatcaaagagaacactggggtatag

  All links  
Disease (2)   
   OMIM (2)   
Gene (27)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (25)   
   PDB (25)   
Protein domain (7)   
   Pfam (7)   
All databases (87)   

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