KEGG   Homo sapiens (human): 6788
Entry
6788              CDS       T01001                                 
Symbol
STK3, KRS1, MST2
Name
(RefSeq) serine/threonine kinase 3
  KO
K04412  serine/threonine kinase 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04390  Hippo signaling pathway
hsa04392  Hippo signaling pathway - multiple species
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    6788 (STK3)
   04390 Hippo signaling pathway
    6788 (STK3)
   04392 Hippo signaling pathway - multiple species
    6788 (STK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6788 (STK3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE20 family
   6788 (STK3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Mst1_SARAH ABC1 Pkinase_fungal Abi_2 Fib_succ_major
Other DBs
NCBI-GeneID: 6788
NCBI-ProteinID: NP_006272
OMIM: 605030
HGNC: 11406
Ensembl: ENSG00000104375
UniProt: Q13188 A0A384MR07
Structure
Position
8:complement(98343975..98942610)
AA seq 491 aa
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
NT seq 1476 nt   +upstreamnt  +downstreamnt
atggagcagccgccggcgcctaagagtaaactaaaaaagctgagtgaagacagtttgact
aagcagcctgaagaagtttttgatgtattagagaagcttggagaagggtcttatggaagt
gtatttaaagcaatacacaaggaatccggtcaagttgtcgcaattaaacaagtacctgtt
gaatcagatcttcaggaaataatcaaagaaatttccataatgcagcaatgtgacagccca
tatgttgtaaagtactatggcagttattttaagaatacagacctctggattgttatggag
tactgtggcgctggctctgtctcagacataattagattacgaaacaagacattaatagaa
gatgaaattgcaaccattcttaaatctacattgaaaggactagaatatttgcactttatg
agaaaaatacacagagatataaaagctggaaatattctcctcaatacagaaggacatgca
aaattggcagattttggagtggctggtcagttaacagatacaatggcaaaacgcaatact
gtaataggaactccattttggatggctcctgaggtgattcaagaaataggctataactgt
gtggccgacatctggtcccttggcattacttctatagaaatggctgaaggaaaacctcct
tatgctgatatacatccaatgagggctatttttatgattcccacaaatccaccaccaaca
ttcagaaagccagaactttggtccgatgatttcaccgattttgttaaaaagtgtttggtg
aagaatcctgagcagagagctactgcaacacaacttttacagcatccttttatcaagaat
gccaaacctgtatcaatattaagagacctgatcacagaagctatggagatcaaagctaaa
agacatgaggaacagcaacgagaattggaagaggaagaagaaaattcggatgaagatgag
ctggattcccacaccatggtgaagactagtgtggagagtgtgggcaccatgcgggccaca
agcacgatgagtgaaggggcccagaccatgattgaacataatagcacgatgttggaatcc
gacttggggaccatggtgataaacagtgaggatgaggaagaagaagatggaactatgaaa
agaaatgcaacctcaccacaagtacaaagaccatctttcatggactactttgataagcaa
gacttcaagaataagagtcacgaaaactgtaatcagaacatgcatgaacccttccctatg
tccaaaaacgtttttcctgataactggaaagttcctcaagatggagactttgactttttg
aaaaatctaagtttagaagaactacagatgcggttaaaagcactggaccccatgatggaa
cgggagatagaagaacttcgtcagagatacactgcgaaaagacagcccattctggatgcg
atggatgcaaagaaaagaaggcagcaaaacttttga

  All links  
Disease (1)   
   OMIM (1)   
Gene (15)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (33)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (30)   
DNA sequence (62)   
   RefSeq(nuc) (38)   
   GenBank (12)   
   EMBL (12)   
3D Structure (11)   
   PDB (11)   
Protein domain (7)   
   Pfam (7)   
All databases (129)   

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KEGG   Homo sapiens (human): 6789
Entry
6789              CDS       T01001                                 
Symbol
STK4, KRS2, MST1, YSK3
Name
(RefSeq) serine/threonine kinase 4
  KO
K04411  serine/threonine kinase 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04068  FoxO signaling pathway
hsa05200  Pathways in cancer
hsa05223  Non-small cell lung cancer
Network
nt06213  Other RAS signaling (cancer)
nt06266  Non-small cell lung cancer
  Element
N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
N00097  Loss of RASSF1 to RAS-RASSF1 signaling pathway
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    6789 (STK4)
   04014 Ras signaling pathway
    6789 (STK4)
   04068 FoxO signaling pathway
    6789 (STK4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6789 (STK4)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    6789 (STK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6789 (STK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE20 family
   6789 (STK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Mst1_SARAH ABC1 Pkinase_fungal Abi_2 Nore1-SARAH
Other DBs
NCBI-GeneID: 6789
NCBI-ProteinID: NP_006273
OMIM: 604965
HGNC: 11408
Ensembl: ENSG00000101109
UniProt: Q13043
Structure
Position
20:44966512..45080021
AA seq 487 aa
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
NT seq 1464 nt   +upstreamnt  +downstreamnt
atggagacggtacagctgaggaacccgccgcgccggcagctgaaaaagttggatgaagat
agtttaaccaaacaaccagaagaagtatttgatgtcttagagaaacttggagaagggtcc
tatggcagcgtatacaaagctattcataaagagaccggccagattgttgctattaagcaa
gttcctgtggaatcagacctccaggagataatcaaagaaatctctataatgcagcaatgt
gacagccctcatgtagtcaaatattatggcagttattttaagaacacagacttatggatc
gttatggagtactgtggggctggttctgtatctgatatcattcgattacgaaataaaacg
ttaacagaagatgaaatagctacaatattacaatcaactcttaagggacttgaatacctt
cattttatgagaaaaatacaccgagatatcaaggcaggaaatattttgctaaatacagaa
ggacatgcaaaacttgcagattttggggtagcaggtcaacttacagataccatggccaag
cggaatacagtgataggaacaccattttggatggctccagaagtgattcaggaaattgga
tacaactgtgtagcagacatctggtccctgggaataactgccatagaaatggctgaagga
aagcccccttatgctgatatccatccaatgagggcaatcttcatgattcctacaaatcct
cctcccacattccgaaaaccagagctatggtcagataactttacagattttgtgaaacag
tgtcttgtaaagagccctgagcagagggccacagccactcagctcctgcagcacccattt
gtcaggagtgccaaaggagtgtcaatactgcgagacttaattaatgaagccatggatgtg
aaactgaaacgccaggaatcccagcagcgggaagtggaccaggacgatgaagaaaactca
gaagaggatgaaatggattctggcacgatggttcgagcagtgggtgatgagatgggcact
gtccgagtagccagcaccatgactgatggagccaatactatgattgagcacgatgacacg
ttgccatcacaactgggcaccatggtgatcaatgcagaggatgaggaagaggaaggaact
atgaaaagaagggatgagaccatgcagcctgcgaaaccatcctttcttgaatattttgaa
caaaaagaaaaggaaaaccagatcaacagctttggcaagagtgtacctggtccactgaaa
aattcttcagattggaaaataccacaggatggagactacgagtttcttaagagttggaca
gtggaggaccttcagaagaggctcttggccctggaccccatgatggagcaggagattgaa
gagatccggcagaagtaccagtccaagcggcagcccatcctggatgccatagaggctaag
aagagacggcaacaaaacttctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (14)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (75)   
   RefSeq(nuc) (15)   
   GenBank (30)   
   EMBL (30)   
3D Structure (10)   
   PDB (10)   
Protein domain (7)   
   Pfam (7)   
All databases (123)   

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