KEGG T01001: 6790

Homo sapiens (human): 6790

Entry

6790 CDS T01001

Gene name

AURKA, AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7

Definition

(RefSeq) aurora kinase A

K11481

aurora kinase A [EC:2.7.11.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04114

Oocyte meiosis

hsa04914

Progesterone-mediated oocyte maturation

Drug target

Alisertib (DG01855):

D10085 D10086

Ilorasertib:

D10423

Tozasertib (DG01365):

D08279 D08344

Brite

KEGG Orthology (KO) [BR:hsa00001]
Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    6790 (AURKA)
Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    6790 (AURKA)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6790 (AURKA)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: AGC group
  AUR family [OT]
   6790 (AURKA)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     6790 (AURKA)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    6790 (AURKA)
   Spindle formation proteins
    6790 (AURKA)
  Sister chromatid separation proteins
   Aurora kinases
    6790 (AURKA)

SSDB

Motif

Pfam:

Pkinase Pkinase_Tyr Kinase-like MTBP_C FTA2 APH Seadorna_VP7

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

O14965(Tchem)

UniProt:

O14965

Structure

PDB:

5L8L 5L8J 5ORL 5G1X 5OS0 5OS5 5L8K 5OS3 4J8M 5ORV 5ORX 5OS4 5OSF 5OSE 5OS1 4UYN 3FDN 1MQ4 5ORZ 5OS2 5DNR 5ORS 5OSD 5ORY 5ORW 4UZH 3O50 5ODT 5DN3 5G15 5LXM 5ORR 4CEG 3LAU 5ORO 5DRD 5DT0 5EW9 5ORN 5ORP 5OS6 3H10 2NP8 5DPV 3EFW 4JBQ 4DEE 3UP2 3E5A 5DT3 3K5U 4UTD 3HA6 3UOL 3MYG 2WTV 4JBP 3W2C 4DEA 3UO4 5DR2 5DR9 4JBO 4O0S 4BN1 3W18 4B0G 3UOD 2WQE 3H0Y 2DWB 5DR6 5ORT 5ONE 4O0U 4O0W 4BYI 2BMC 2XNG 5OBR 3VAP 4C3P 4JAJ 3W10 3UO5 3COH 2W1G 4BYJ 3M11 1OL7 5AAF 4C3R 4ZTQ 4PRJ 3W16 4DHF 3UNZ 3UO6 3UOH 3P9J 2XNE 2X6D 5AAG 4ZTR 2W1F 5DT4 5OBJ 4ZTS 3UOJ 3R21 3R22 2XRU 1MUO 2X81 3H0Z 2W1E 3UOK 2W1D 5DOS 4ZS0 4DEB 4DED 3UP7 3NRM 5AAD 5AAE 4J8N 4UZD 4JAI 3O51 2W1C 2WTW 2X6E 3QBN 2J4Z 2J50 2C6D 2C6E 1OL5 1OL6

Position

20q13.2

AA seq 403 aa
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS

NT seq 1212 nt +upstreamnt +downstreamnt
atggaccgatctaaagaaaactgcatttcaggacctgttaaggctacagctccagttgga
ggtccaaaacgtgttctcgtgactcagcaatttccttgtcagaatccattacctgtaaat
agtggccaggctcagcgggtcttgtgtccttcaaattcttcccagcgcattcctttgcaa
gcacaaaagcttgtctccagtcacaagccggttcagaatcagaagcagaagcaattgcag
gcaaccagtgtacctcatcctgtctccaggccactgaataacacccaaaagagcaagcag
cccctgccatcggcacctgaaaataatcctgaggaggaactggcatcaaaacagaaaaat
gaagaatcaaaaaagaggcagtgggctttggaagactttgaaattggtcgccctctgggt
aaaggaaagtttggtaatgtttatttggcaagagaaaagcaaagcaagtttattctggct
cttaaagtgttatttaaagctcagctggagaaagccggagtggagcatcagctcagaaga
gaagtagaaatacagtcccaccttcggcatcctaatattcttagactgtatggttatttc
catgatgctaccagagtctacctaattctggaatatgcaccacttggaacagtttataga
gaacttcagaaactttcaaagtttgatgagcagagaactgctacttatataacagaattg
gcaaatgccctgtcttactgtcattcgaagagagttattcatagagacattaagccagag
aacttacttcttggatcagctggagagcttaaaattgcagattttgggtggtcagtacat
gctccatcttccaggaggaccactctctgtggcaccctggactacctgccccctgaaatg
attgaaggtcggatgcatgatgagaaggtggatctctggagccttggagttctttgctat
gaatttttagttgggaagcctccttttgaggcaaacacataccaagagacctacaaaaga
atatcacgggttgaattcacattccctgactttgtaacagagggagccagggacctcatt
tcaagactgttgaagcataatcccagccagaggccaatgctcagagaagtacttgaacac
ccctggatcacagcaaattcatcaaaaccatcaaattgccaaaacaaagaatcagctagc
aaacagtcttag

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