KEGG   Homo sapiens (human): 6795Help
Entry
6795              CDS       T01001                                 

Gene name
AURKC, AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C
Definition
(RefSeq) aurora kinase C
  KO
K11480  aurora kinase C [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H01282  Spermatogenic failure
Drug target
Ilorasertib: D10423
Tozasertib (DG01365): D08279 D08344
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6795 (AURKC)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    6795 (AURKC)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6795 (AURKC)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AUR family [OT]
   6795 (AURKC)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     6795 (AURKC)
  Sister chromatid separation proteins
   Aurora kinases
    6795 (AURKC)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Kinase-like Kdo YrbL-PhoP_reg APH
Motif
Other DBs
NCBI-GeneID: 6795
NCBI-ProteinID: NP_001015878
OMIM: 603495
HGNC: 11391
Ensembl: ENSG00000105146
Vega: OTTHUMG00000183106
Pharos: Q9UQB9(Tchem)
UniProt: Q9UQB9
Structure
PDB: 

Position
19q13.43
AA seq 309 aa AA seqDB search
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
NT seq 930 nt NT seq  +upstreamnt  +downstreamnt
atgagctcccccagagctgtggtgcagctgggcaaagctcaacctgcaggcgaagagttg
gctacagcaaaccaaacagcccagcagcccagcagcccagccatgcggcgcctcacagtc
gatgactttgaaatcgggcgtcccctgggcaaggggaaatttgggaatgtgtacctggct
cggctcaaggaaagccatttcattgtggccctgaaggttctcttcaagtcgcagatagag
aaggaaggactggagcaccagctgcgccgggaaattgagatccaggctcatctacaacac
cccaatatcctgcgcctgtataactatttccatgatgcacgccgggtgtacctgattctg
gaatatgctccaaggggtgagctctacaaggagctgcagaaaagcgagaaattagatgaa
cagcgcacagccacgataatagaggagttggcagatgccctgacctactgccatgacaag
aaagtgattcacagagatattaagccagagaacctgctgctggggttcaggggtgaggtg
aagattgcagattttggctggtctgtgcacaccccctccctgaggaggaagacaatgtgt
gggacactggactacttgccgccagaaatgattgaggggagaacatatgatgaaaaggtg
gatttgtggtgcattggagtgctctgctatgagctgctggtgggatatccaccctttgag
agcgcctcccacagtgagacttacagacgcatcctcaaggtagatgtgaggtttccacta
tcaatgcctctgggggcccgggacttgatttccaggcttctcagataccagcccttggag
agactgcccctggcccagatcctgaagcacccctgggttcaggcccactcccgaagggtg
ctgcctccctgtgctcagatggcttcctga

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Ontology (4)   
   KEGG BRITE (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (22)   
   RefSeq(nuc) (4)   
   GenBank (9)   
   EMBL (9)   
Protein domain (6)   
   Pfam (6)   
All databases (60)   

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