KEGG   Homo sapiens (human): 6916Help
Entry
6916              CDS       T01001                                 

Gene name
TBXAS1, BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
Definition
(RefSeq) thromboxane A synthase 1
  KO
K01832  thromboxane-A synthase [EC:5.3.99.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
hsa04611  Platelet activation
Disease
H00490  Diaphyseal dysplasia with anemia (Ghosal)
Drug target
Dazmegrel: D03661
Dazoxiben hydrochloride: D03663
Furegrelate sodium: D04276
Ozagrel (DG01256): D01683 D01684 D08327
Picotamide: D07140
Pirmagrel: D05502
Ridogrel: D05727
Trapidil: D01220
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Lipid metabolism
   00590 Arachidonic acid metabolism
    6916 (TBXAS1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    6916 (TBXAS1)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.5  thromboxane-A synthase
     6916 (TBXAS1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP5 family
   6916 (TBXAS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: p450
Motif
Other DBs
NCBI-GeneID: 6916
NCBI-ProteinID: NP_001052
OMIM: 274180
HGNC: 11609
Ensembl: ENSG00000059377
Vega: OTTHUMG00000157302
Pharos: P24557(Tchem)
UniProt: P24557 Q53F23
Position
7q34
AA seq 534 aa AA seqDB search
MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC
LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
NT seq 1605 nt NT seq  +upstreamnt  +downstreamnt
atgatggaagccttggggtttctaaaattggaagtgaatggccccatggtgacggtggcc
ctgtcagtggctctcttggccctcctgaaatggtactccacatcagcattctcaagactg
gagaagttaggcctcagacatcccaagccttctcctttcattggaaacttgacatttttc
cgccagggtttttgggaaagccaaatggagctcagaaagctgtatggacctctgtgtggg
tactatcttggtcgtcggatgtttattgttatttctgagccagacatgatcaagcaggtg
ttggttgagaacttcagtaactttaccaacagaatggcgtcgggtttggagttcaagtcg
gtagccgacagcgttctgtttttacgtgacaaaagatgggaagaggtcagaggtgccctg
atgtctgctttcagtcctgaaaagctgaacgagatggttcccctcatcagccaagcctgc
gaccttctcctggctcatttaaaacgctatgcggaatctggggacgcatttgacatccag
aggtgctactgcaattacaccacagatgtggttgccagcgtcgcctttggcaccccggtg
gactcctggcaggcccctgaggatccctttgtgaaacactgcaagcgtttcttcgaattc
tgcatccccagacctatcctggttttactcttatcatttccatccataatggtcccactg
gcccggattttgcccaataagaaccgagacgaactgaatggcttttttaacaaactcatt
aggaatgtgattgccttgcgggaccagcaagctgccgaagagaggcggagagacttcctc
caaatggtcctggatgcccgacattctgcaagtcccatgggcgtgcaagactttgacatc
gtcagagacgttttctcctctactgggtgcaagccgaacccttcccggcaacaccagccc
agccctatggccaggcctttgactgtggatgagattgtgggccaggccttcatcttcctc
atcgctggctatgaaatcatcaccaacacactttcttttgccacctacctactggccacc
aaccctgactgccaagagaagcttctgagagaggtagacgtttttaaggagaaacacatg
gcccctgagttctgcagcctcgaggaaggcctgccctatctggacatggtgattgcagag
acgctgaggatgtacccgccagctttcagattcacacgggaggcagctcaggactgcgag
gtgctggggcagcgcatccccgcaggcgctgtgctagagatggccgtgggtgccctgcac
catgaccctgagcactggccaagcccggagaccttcaaccctgaaaggttcacggctgag
gcccggcagcagcaccggcccttcacgtacctgcccttcggggccggcccacggagctgc
ctcggggtgcgtctagggctgcttgaggtcaagttgacactgctccacgtgctgcacaag
ttccggttccaagcctgccctgagacccaggtaccgctgcagctagaatccaaatctgcc
ctaggtccaaaaaatggtgtctatatcaagatcgtatcccgctga

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