KEGG   Homo sapiens (human): 6932Help
Entry
6932              CDS       T01001                                 

Gene name
TCF7, TCF-1
Definition
(RefSeq) transcription factor 7
  KO
K02620  transcription factor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04520  Adherens junction
hsa04916  Melanogenesis
hsa04934  Cushing syndrome
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05217  Basal cell carcinoma
hsa05221  Acute myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
hsa_M00677  Wnt signaling
Network
N00056  Wnt signaling pathway
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N00061  CDH1-reduced expression to Wnt signaling pathway
N00175  KSHV LANA to Wnt signaling pathway
N00242  Mutation-inactivated AXIN to Wnt signaling pathway
N00257  Loss of CDH1 to Wnt signaling pathway
N00258  Mutation-inactivated CDH1 to Wnt signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    6932 (TCF7)
   04390 Hippo signaling pathway
    6932 (TCF7)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    6932 (TCF7)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    6932 (TCF7)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    6932 (TCF7)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    6932 (TCF7)
   05225 Hepatocellular carcinoma
    6932 (TCF7)
   05226 Gastric cancer
    6932 (TCF7)
   05216 Thyroid cancer
    6932 (TCF7)
   05221 Acute myeloid leukemia
    6932 (TCF7)
   05217 Basal cell carcinoma
    6932 (TCF7)
   05215 Prostate cancer
    6932 (TCF7)
   05213 Endometrial cancer
    6932 (TCF7)
   05224 Breast cancer
    6932 (TCF7)
  09166 Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    6932 (TCF7)
  09167 Endocrine and metabolic diseases
   04934 Cushing syndrome
    6932 (TCF7)
  09172 Infectious diseases: Viral
   05165 Human papillomavirus infection
    6932 (TCF7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6932 (TCF7)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    6932 (TCF7)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: CTNNB1_binding HMG_box HMG_box_2
Motif
Other DBs
NCBI-GeneID: 6932
NCBI-ProteinID: NP_003193
OMIM: 189908
HGNC: 11639
Ensembl: ENSG00000081059
Vega: OTTHUMG00000129124
Pharos: P36402(Tbio)
UniProt: P36402 B3KQ75
Position
5q31.1
AA seq 384 aa AA seqDB search
MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESE
GAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKET
VYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQ
KQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPS
GKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAIN
QILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTGG
KRNAFGTYPEKAAAPAPFLPMTVL
NT seq 1155 nt NT seq  +upstreamnt  +downstreamnt
atgccgcagctggactccggcgggggcggcgcgggcggcggcgacgacctcggcgcgccg
gacgagctgctggccttccaggatgaaggcgaggagcaggacgacaagagccgcgacagc
gccgccggtcccgagcgcgacctggccgagctcaagtcgtcgctcgtgaacgagtccgag
ggcgcggccggcggcgcagggatcccgggggtcccgggggccggcgccggggcccgcggc
gaggccgaggctctcgggcgggaacacgctgcgcagagactcttcccggacaaacttcca
gagcccctggaggacggcctgaaggccccggagtgcaccagcggcatgtacaaagagacc
gtctactccgccttcaatctgctcatgcattacccacccccctcgggagcagggcagcac
ccccagccgcagcccccgctgcacaaggccaatcagcccccccacggtgtcccccaactc
tctctctacgaacatttcaacagcccacatcccacccctgcacctgcggacatcagccag
aagcaagttcacaggcctctgcagacccctgacctctctggcttctactccctgacctca
ggcagcatggggcagctcccccacactgtgagctggttcacccacccatccttgatgcta
ggttctggtgtacctggtcacccagcagccatcccccacccggccattgtgcccccctca
gggaagcaggagctgcagcccttcgaccgcaacctgaagacacaagcagagtccaaggca
gagaaggaggccaagaagccaaccatcaagaagcccctcaatgccttcatgctgtacatg
aaggagatgagagccaaggtcattgcagagtgcacacttaaggagagcgctgccatcaac
cagatcctgggccgcaggtggcacgcgctgtcgcgagaagagcaggccaagtactatgag
ctggcccgcaaggagaggcagctgcacatgcagctatacccaggctggtcagcgcgggac
aactacgggaagaagaagaggcggtcgagggaaaagcaccaagaatccaccacaggagga
aaaagaaatgcattcggtacttacccggagaaggccgctgccccagccccgttccttccg
atgacagtgctctag

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