KEGG   Homo sapiens (human): 6935
Entry
6935              CDS       T01001                                 
Symbol
ZEB1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Name
(RefSeq) zinc finger E-box binding homeobox 1
  KO
K09299  zinc finger homeobox protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05202  Transcriptional misregulation in cancer
hsa05206  MicroRNAs in cancer
hsa05215  Prostate cancer
Network
nt06240  Transcription (cancer)
nt06272  Prostate cancer
  Element
N00128  TMPRSS2-ERG fusion to transcriptional activation
Disease
H00960  Fuchs corneal dystrophy
H00961  Posterior polymorphous corneal dystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    6935 (ZEB1)
   05206 MicroRNAs in cancer
    6935 (ZEB1)
  09162 Cancer: specific types
   05215 Prostate cancer
    6935 (ZEB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6935 (ZEB1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Homeo domain ZF
    6935 (ZEB1)
SSDB
Motif
Pfam: zf-C2H2 zf-H2C2_2 zf-C2H2_4 zf-C2H2_jaz zf-Di19 zf-met Homeodomain zf-C2H2_15 zf-C2H2_6 Zf-C2H2_ZNF451_C zf-C2HE Zn_SUZ12
Other DBs
NCBI-GeneID: 6935
NCBI-ProteinID: NP_110378
OMIM: 189909
HGNC: 11642
Ensembl: ENSG00000148516
UniProt: P37275 B2RBI8
Structure
Position
10:31318417..31529804
AA seq 1124 aa
MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD
LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ
NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK
RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF
KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG
RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV
ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV
DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE
QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD
INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY
ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND
QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL
YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD
SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ
VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE
NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY
QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG
DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA
ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA
NT seq 3375 nt   +upstreamnt  +downstreamnt
atggcggatggccccaggtgtaagcgcagaaagcaggcgaacccgcggcgcaataacgtt
acaaattataatactgtggtagaaacaaattcagattcagatgatgaagacaaactgcat
attgtggaagaagaaagtgttacagatgcagctgactgtgaaggtgtaccagaggatgac
ctgccaacagaccagacagtgttaccagggaggagcagtgaaagagaagggaatgctaag
aactgctgggaggatgacagaaaggaagggcaagaaatcctggggcctgaagctcaggca
gatgaagcaggatgtacagtaaaagatgatgaatgcgagtcagatgcagaaaatgagcaa
aaccatgatcctaatgttgaagagtttctacaacaacaagacactgctgtcatttttcct
gaggcacctgaagaggaccagaggcagggcacaccagaagccagtggtcatgatgaaaat
ggaacaccagatgcattttcacaattactcacctgtccatattgtgatagaggctataaa
cgctttacctctctgaaagaacacattaaatatcgtcatgaaaagaatgaagataacttt
agttgctccctgtgcagttacacctttgcatacagaacccaacttgaacgtcacatgaca
tcacataaatcaggaagagatcaaagacatgtgacgcagtctgggtgtaatcgtaaattc
aaatgcactgagtgtggaaaagctttcaaatacaaacatcacctaaaagagcacttaaga
attcacagtggagagaagccatatgaatgcccaaactgcaagaaacgcttttcccattct
ggctcctatagctcacacataagcagtaagaaatgtatcagcttgatacctgtgaatggg
cgaccaagaacaggactcaagacatctcagtgttcttcaccgtctctttcagcatcacca
ggcagtcccacacgaccacagatacggcaaaagatagagaataaaccccttcaagaacaa
ctttctgttaaccaaattaaaactgaacctgtggattatgaattcaaacccatagtggtt
gcttcaggaatcaactgttcaacccctttacaaaatggggttttcactggtggtggccca
ttacaggcaaccagttctcctcagggcatggtgcaagctgttgttctgccaacagttggt
ttggtgtctcccataagtatcaatttaagtgatattcagaatgtacttaaagtggcggta
gatggtaatgtaataaggcaagtgttggagaataatcaagccaatcttgcatccaaagaa
caagaaacaatcaatgcttcacccatacaacaaggtggccattctgttatttcagccatc
agtcttcctttggttgatcaagatggaacaaccaaaattatcatcaactacagtcttgag
cagcctagccaacttcaagttgttcctcaaaatttaaaaaaagaaaatccagtcgctaca
aacagttgtaaaagtgaaaagttaccagaagatcttactgttaagtctgagaaggacaaa
agctttgaagggggggtgaatgatagcacttgtcttctgtgtgatgattgtccaggagat
attaatgcacttccagaattaaagcactatgacctaaagcagcctactcagcctcctcca
ctccctgcagcagaagctgagaagcctgagtcctctgtttcatcagctactggagatggc
aatttgtctcctagtcagccacctttaaagaacctcttgtctctcctaaaagcatattat
gctttgaatgcacaaccaagtgcagaagagctctcaaaaattgctgattcagtaaaccta
ccactggatgtagtaaaaaagtggtttgaaaagatgcaagctggacagatttcagtgcag
tcttctgaaccatcttctcctgaaccaggcaaagtaaatatccctgccaagaacaatgat
cagcctcaatctgcaaatgcaaatgaaccccaggacagcacagtaaatctacaaagtcct
ttgaagatgactaactccccagttttaccagtgggatcaaccaccaatggttccagaagt
agtacaccatccccatcacctctaaacctttcctcatccagaaatacacagggttacttg
tacacagctgagggtgcacaagaagagccacaagtagaacctcttgatctttcactacca
aagcaacagggagaattattagaaaggtcaactatcactagtgtttaccagaacagtgtt
tattctgtccaggaagaacccttgaacttgtcttgcgcaaaaaaggagccacaaaaggac
agttgtgttacagactcagaaccagttgtaaatgtaatcccaccaagtgccaaccccata
aatatcgctatacctacagtcactgcccagttacccacaatcgtggccattgctgaccag
aacagtgttccatgcttaagagcgctagctgccaataagcaaacgattctgattccccag
gtggcatacacctactcaactacggtcagccctgcagtccaagaaccacccttgaaagtg
atccagccaaatggaaatcaggatgaaagacaagatactagctcagaaggagtatcaaat
gtagaggatcagaatgactctgattctacaccgcccaaaaagaaaatgcggaagacagaa
aatggaatgtatgcttgtgatttgtgtgacaagatattccaaaagagtagttcattattg
agacataaatatgaacacacaggtaaaagacctcatgagtgtggaatctgtaaaaaggca
tttaaacacaaacatcatttgattgaacacatgcgattacattctggagaaaagccctat
caatgtgacaaatgtggaaagcgcttctcacactctgggtcttattctcaacacatgaat
catcgctactcctactgtaagagagaagcggaagaacgtgacagcacagagcaggaagag
gcagggcctgaaatcctctcgaatgagcacgtgggtgccagggcgtctccctcacagggc
gactcggacgagagagagagtttgacaagggaagaggatgaagacagtgaaaaagaggaa
gaggaggaggataaagagatggaagaattgcaggaagaaaaagaatgtgaaaaaccacaa
ggggatgaggaagaggaggaggaggaggaagaagtggaagaagaagaggtagaagaggca
gagaatgagggagaagaagcaaaaactgaaggtctgatgaaggatgacagggctgaaagt
caagcaagcagcttaggacaaaaagtaggcgagagtagtgagcaagtgtctgaagaaaag
acaaatgaagcctaa

  All links  
Disease (3)   
   OMIM (3)   
Gene (25)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (74)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (71)   
DNA sequence (143)   
   RefSeq(nuc) (71)   
   GenBank (36)   
   EMBL (36)   
3D Structure (1)   
   PDB (1)   
Protein domain (12)   
   Pfam (12)   
All databases (258)   

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