KEGG   Homo sapiens (human): 6935
Entry
6935              CDS       T01001                                 

Gene name
ZEB1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Definition
(RefSeq) zinc finger E-box binding homeobox 1
  KO
K09299  zinc finger homeobox protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05202  Transcriptional misregulation in cancer
hsa05206  MicroRNAs in cancer
hsa05215  Prostate cancer
Network
nt06240  Transcription
nt06272  Prostate cancer
  Element
N00128  TMPRSS2-ERG fusion to transcriptional activation
Disease
H00960  Fuchs corneal dystrophy
H00961  Posterior polymorphous corneal dystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    6935 (ZEB1)
   05206 MicroRNAs in cancer
    6935 (ZEB1)
  09162 Cancer: specific types
   05215 Prostate cancer
    6935 (ZEB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6935 (ZEB1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Homeo domain only, AbdB
    6935 (ZEB1)
SSDB
Motif
Pfam: zf-H2C2_2 zf-C2H2 zf-C2H2_4 zf-met zf-Di19 zf-C2H2_jaz Homeodomain zf-C2H2_6 zf-C2HE zf-C2H2_2
Other DBs
NCBI-GeneID: 6935
NCBI-ProteinID: NP_110378
OMIM: 189909
HGNC: 11642
Ensembl: ENSG00000148516
Vega: OTTHUMG00000017907
Pharos: P37275(Tbio)
UniProt: P37275 B2RBI8
Structure
PDB: 
2E19

Position
10p11.22
AA seq 1124 aa
MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD
LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ
NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK
RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF
KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG
RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV
ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV
DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE
QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD
INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY
ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND
QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL
YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD
SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ
VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE
NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY
QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG
DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA
ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA
NT seq 3375 nt   +upstreamnt  +downstreamnt
atggcggatggccccaggtgtaagcgcagaaagcaggcgaacccgcggcgcaataacgtt
acaaattataatactgtggtagaaacaaattcagattcagatgatgaagacaaactgcat
attgtggaagaagaaagtgttacagatgcagctgactgtgaaggtgtaccagaggatgac
ctgccaacagaccagacagtgttaccagggaggagcagtgaaagagaagggaatgctaag
aactgctgggaggatgacagaaaggaagggcaagaaatcctggggcctgaagctcaggca
gatgaagcaggatgtacagtaaaagatgatgaatgcgagtcagatgcagaaaatgagcaa
aaccatgatcctaatgttgaagagtttctacaacaacaagacactgctgtcatttttcct
gaggcacctgaagaggaccagaggcagggcacaccagaagccagtggtcatgatgaaaat
ggaacaccagatgcattttcacaattactcacctgtccatattgtgatagaggctataaa
cgctttacctctctgaaagaacacattaaatatcgtcatgaaaagaatgaagataacttt
agttgctccctgtgcagttacacctttgcatacagaacccaacttgaacgtcacatgaca
tcacataaatcaggaagagatcaaagacatgtgacgcagtctgggtgtaatcgtaaattc
aaatgcactgagtgtggaaaagctttcaaatacaaacatcacctaaaagagcacttaaga
attcacagtggagagaagccatatgaatgcccaaactgcaagaaacgcttttcccattct
ggctcctatagctcacacataagcagtaagaaatgtatcagcttgatacctgtgaatggg
cgaccaagaacaggactcaagacatctcagtgttcttcaccgtctctttcagcatcacca
ggcagtcccacacgaccacagatacggcaaaagatagagaataaaccccttcaagaacaa
ctttctgttaaccaaattaaaactgaacctgtggattatgaattcaaacccatagtggtt
gcttcaggaatcaactgttcaacccctttacaaaatggggttttcactggtggtggccca
ttacaggcaaccagttctcctcagggcatggtgcaagctgttgttctgccaacagttggt
ttggtgtctcccataagtatcaatttaagtgatattcagaatgtacttaaagtggcggta
gatggtaatgtaataaggcaagtgttggagaataatcaagccaatcttgcatccaaagaa
caagaaacaatcaatgcttcacccatacaacaaggtggccattctgttatttcagccatc
agtcttcctttggttgatcaagatggaacaaccaaaattatcatcaactacagtcttgag
cagcctagccaacttcaagttgttcctcaaaatttaaaaaaagaaaatccagtcgctaca
aacagttgtaaaagtgaaaagttaccagaagatcttactgttaagtctgagaaggacaaa
agctttgaagggggggtgaatgatagcacttgtcttctgtgtgatgattgtccaggagat
attaatgcacttccagaattaaagcactatgacctaaagcagcctactcagcctcctcca
ctccctgcagcagaagctgagaagcctgagtcctctgtttcatcagctactggagatggc
aatttgtctcctagtcagccacctttaaagaacctcttgtctctcctaaaagcatattat
gctttgaatgcacaaccaagtgcagaagagctctcaaaaattgctgattcagtaaaccta
ccactggatgtagtaaaaaagtggtttgaaaagatgcaagctggacagatttcagtgcag
tcttctgaaccatcttctcctgaaccaggcaaagtaaatatccctgccaagaacaatgat
cagcctcaatctgcaaatgcaaatgaaccccaggacagcacagtaaatctacaaagtcct
ttgaagatgactaactccccagttttaccagtgggatcaaccaccaatggttccagaagt
agtacaccatccccatcacctctaaacctttcctcatccagaaatacacagggttacttg
tacacagctgagggtgcacaagaagagccacaagtagaacctcttgatctttcactacca
aagcaacagggagaattattagaaaggtcaactatcactagtgtttaccagaacagtgtt
tattctgtccaggaagaacccttgaacttgtcttgcgcaaaaaaggagccacaaaaggac
agttgtgttacagactcagaaccagttgtaaatgtaatcccaccaagtgccaaccccata
aatatcgctatacctacagtcactgcccagttacccacaatcgtggccattgctgaccag
aacagtgttccatgcttaagagcgctagctgccaataagcaaacgattctgattccccag
gtggcatacacctactcaactacggtcagccctgcagtccaagaaccacccttgaaagtg
atccagccaaatggaaatcaggatgaaagacaagatactagctcagaaggagtatcaaat
gtagaggatcagaatgactctgattctacaccgcccaaaaagaaaatgcggaagacagaa
aatggaatgtatgcttgtgatttgtgtgacaagatattccaaaagagtagttcattattg
agacataaatatgaacacacaggtaaaagacctcatgagtgtggaatctgtaaaaaggca
tttaaacacaaacatcatttgattgaacacatgcgattacattctggagaaaagccctat
caatgtgacaaatgtggaaagcgcttctcacactctgggtcttattctcaacacatgaat
catcgctactcctactgtaagagagaagcggaagaacgtgacagcacagagcaggaagag
gcagggcctgaaatcctctcgaatgagcacgtgggtgccagggcgtctccctcacagggc
gactcggacgagagagagagtttgacaagggaagaggatgaagacagtgaaaaagaggaa
gaggaggaggataaagagatggaagaattgcaggaagaaaaagaatgtgaaaaaccacaa
ggggatgaggaagaggaggaggaggaggaagaagtggaagaagaagaggtagaagaggca
gagaatgagggagaagaagcaaaaactgaaggtctgatgaaggatgacagggctgaaagt
caagcaagcagcttaggacaaaaagtaggcgagagtagtgagcaagtgtctgaagaaaag
acaaatgaagcctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (1)   
   KEGG NETWORK (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (47)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (44)   
DNA sequence (116)   
   RefSeq(nuc) (44)   
   GenBank (36)   
   EMBL (36)   
Protein domain (10)   
   Pfam (10)   
All databases (213)   

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