KEGG   Homo sapiens (human): 699
Entry
699               CDS       T01001                                 

Gene name
BUB1, BUB1A, BUB1L, hBUB1
Definition
(RefSeq) BUB1 mitotic checkpoint serine/threonine kinase
  KO
K02178  checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    699 (BUB1)
   04114 Oocyte meiosis
    699 (BUB1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    699 (BUB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    699 (BUB1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    699 (BUB1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     699 (BUB1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  BUB family
   699 (BUB1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     699 (BUB1)
Motif
Pfam: Mad3_BUB1_I Pkinase Mad3_BUB1_I_2 PK_Tyr_Ser-Thr Inhibitor_I68
Other DBs
NCBI-GeneID: 699
NCBI-ProteinID: NP_004327
OMIM: 602452
HGNC: 1148
Ensembl: ENSG00000169679
Vega: OTTHUMG00000153638
Pharos: O43683(Tchem)
UniProt: O43683
Structure
PDB: 

Position
2q13
AA seq 1085 aa
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
NT seq 3258 nt   +upstreamnt  +downstreamnt
atggacaccccggaaaatgtccttcagatgcttgaagcccacatgcagagctacaagggc
aatgaccctcttggtgaatgggaaagatacatacagtgggtagaagagaattttcctgag
aataaagaatacttgataactttactagaacatttaatgaaggaatttttagataagaag
aaataccacaatgacccaagattcatcagttattgtttaaaatttgctgagtacaacagt
gacctccatcaattttttgagtttctgtacaaccatgggattggaaccctgtcatcccct
ctgtacattgcctgggcggggcatctggaagcccaaggagagctgcagcatgccagtgct
gtccttcagagaggaattcaaaaccaggctgaacccagagagttcctgcaacaacaatac
aggttatttcagacacgcctcactgaaacccatttgccagctcaagctagaacctcagaa
cctctgcataatgttcaggttttaaatcaaatgataacatcaaaatcaaatccaggaaat
aacatggcctgcatttctaagaatcagggttcagagctttctggagtgatatcttcagct
tgtgataaagagtcaaatatggaacgaagagtgatcacgatttctaaatcagaatattct
gtgcactcatctttggcatccaaagttgatgttgagcaggttgttatgtattgcaaggag
aagcttattcgtggggaatcagaattttcctttgaagaattgagagcccagaaatacaat
caacggagaaagcatgagcaatgggtaaatgaagacagacattatatgaaaaggaaagaa
gcaaatgcttttgaagaacagctattaaaacagaaaatggatgaacttcataagaagttg
catcaggtggtggagacatcccatgaggatctgcccgcttcccaggaaaggtccgaggtt
aatccagcacgtatggggccaagtgtaggctcccagcaggaactgagagcgccatgtctt
ccagtaacctatcagcagacaccagtgaacatggaaaagaacccaagagaggcacctcct
gttgttcctcctttggcaaatgctatttctgcagctttggtgtccccagccaccagccag
agcattgctcctcctgttcctttgaaagcccagacagtaacagactccatgtttgcagtg
gccagcaaagatgctggatgtgtgaataagagtactcatgaattcaagccacagagtgga
gcagagatcaaagaagggtgtgaaacacataaggttgccaacacaagttcttttcacaca
actccaaacacatcactgggaatggttcaggcaacgccatccaaagtgcagccatcaccc
accgtgcacacaaaagaagcattaggtttcatcatgaatatgtttcaggctcctacactt
cctgatatttctgatgacaaagatgaatggcaatctctagatcaaaatgaagatgcattt
gaagcccagtttcaaaaaaatgtaaggtcatctggggcttggggagtcaataagatcatc
tcttctttgtcatctgcttttcatgtgtttgaagatggaaacaaagaaaattatggatta
ccacagcctaaaaataaacccacaggagccaggacctttggagaacgctctgtcagcaga
cttccttcaaaaccaaaggaggaagtgcctcatgctgaagagtttttggatgactcaact
gtatggggtattcgctgcaacaaaaccctggcacccagtcctaagagcccaggagacttc
acatctgctgcacaacttgcgtctacaccattccacaagcttccagtggagtcagtgcac
attttagaagataaagaaaatgtggtagcaaaacagtgtacccaggcgactttggattct
tgtgaggaaaacatggtggtgccttcaagggatggaaaattcagtccaattcaagagaaa
agcccaaaacaggccttgtcgtctcacatgtattcagcatccttacttcgtctgagccag
cctgctgcaggtggggtacttacctgtgaggcagagttgggcgttgaggcttgcagactc
acagacactgacgctgccattgcagaagatccaccagatgctattgctgggctccaagca
gaatggatgcagatgagttcacttgggactgttgatgctccaaacttcattgttgggaac
ccatgggatgataagctgattttcaaacttttatctgggctttctaaaccagtgagttcc
tatccaaatacttttgaatggcaatgtaaacttccagccatcaagcccaagactgaattt
caattgggttctaagctggtctatgtccatcaccttcttggagaaggagcctttgcccag
gtgtacgaagctacccagggagatctgaatgatgctaaaaataaacagaaatttgtttta
aaggtccaaaagcctgccaacccctgggaattctacattgggacccagttgatggaaaga
ctaaagccatctatgcagcacatgtttatgaagttctattctgcccacttattccagaat
ggcagtgtattagtaggagagctctacagctatggaacattattaaatgccattaacctc
tataaaaatacccctgaaaaagtgatgcctcaaggtcttgtcatctcttttgctatgaga
atgctttacatgattgagcaagtgcatgactgtgaaatcattcatggagacattaaacca
gacaatttcatacttggaaacggatttttggaacaggatgatgaagatgatttatctgct
ggcttggcactgattgacctgggtcagagtatagatatgaaactttttccaaaaggaact
atattcacagcaaagtgtgaaacatctggttttcagtgtgttgagatgctcagcaacaaa
ccatggaactaccagatcgattactttggggttgctgcaacagtatattgcatgctcttt
ggcacttacatgaaagtgaaaaatgaaggaggagagtgtaagcctgaaggtctttttaga
aggcttcctcatttggatatgtggaatgaattttttcatgttatgttgaatattccagat
tgtcatcatcttccatctttggatttgttaaggcaaaagctgaagaaagtatttcaacaa
cactatactaacaagattagggccctacgtaataggctaattgtactgctcttagaatgt
aagcgttcacgaaaataa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (32)   
   RefSeq(nuc) (4)   
   GenBank (14)   
   EMBL (14)   
Protein domain (5)   
   Pfam (5)   
All databases (74)   

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