KEGG   Homo sapiens (human): 699
Entry
699               CDS       T01001                                 
Symbol
BUB1, BUB1A, BUB1L, MCPH30, hBUB1
Name
(RefSeq) BUB1 mitotic checkpoint serine/threonine kinase
  KO
K02178  checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01529  Recruitment and formation of the MCC
N01534  Dynein recruitment to the kinetochore
Disease
H00020  Colorectal cancer
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    699 (BUB1)
   04114 Oocyte meiosis
    699 (BUB1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    699 (BUB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    699 (BUB1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    699 (BUB1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     699 (BUB1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  BUB family
   699 (BUB1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     699 (BUB1)
SSDB
Motif
Pfam: Mad3_BUB1_I Pkinase Mad3_BUB1_I_2 PK_Tyr_Ser-Thr SNaCT7 Inhibitor_I68 TPR_14
Other DBs
NCBI-GeneID: 699
NCBI-ProteinID: NP_004327
OMIM: 602452
HGNC: 1148
Ensembl: ENSG00000169679
UniProt: O43683
Structure
Position
2:complement(110637528..110678063)
AA seq 1085 aa
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
NT seq 3258 nt   +upstreamnt  +downstreamnt
atggacaccccggaaaatgtccttcagatgcttgaagcccacatgcagagctacaagggc
aatgaccctcttggtgaatgggaaagatacatacagtgggtagaagagaattttcctgag
aataaagaatacttgataactttactagaacatttaatgaaggaatttttagataagaag
aaataccacaatgacccaagattcatcagttattgtttaaaatttgctgagtacaacagt
gacctccatcaattttttgagtttctgtacaaccatgggattggaaccctgtcatcccct
ctgtacattgcctgggcggggcatctggaagcccaaggagagctgcagcatgccagtgct
gtccttcagagaggaattcaaaaccaggctgaacccagagagttcctgcaacaacaatac
aggttatttcagacacgcctcactgaaacccatttgccagctcaagctagaacctcagaa
cctctgcataatgttcaggttttaaatcaaatgataacatcaaaatcaaatccaggaaat
aacatggcctgcatttctaagaatcagggttcagagctttctggagtgatatcttcagct
tgtgataaagagtcaaatatggaacgaagagtgatcacgatttctaaatcagaatattct
gtgcactcatctttggcatccaaagttgatgttgagcaggttgttatgtattgcaaggag
aagcttattcgtggggaatcagaattttcctttgaagaattgagagcccagaaatacaat
caacggagaaagcatgagcaatgggtaaatgaagacagacattatatgaaaaggaaagaa
gcaaatgcttttgaagaacagctattaaaacagaaaatggatgaacttcataagaagttg
catcaggtggtggagacatcccatgaggatctgcccgcttcccaggaaaggtccgaggtt
aatccagcacgtatggggccaagtgtaggctcccagcaggaactgagagcgccatgtctt
ccagtaacctatcagcagacaccagtgaacatggaaaagaacccaagagaggcacctcct
gttgttcctcctttggcaaatgctatttctgcagctttggtgtccccagccaccagccag
agcattgctcctcctgttcctttgaaagcccagacagtaacagactccatgtttgcagtg
gccagcaaagatgctggatgtgtgaataagagtactcatgaattcaagccacagagtgga
gcagagatcaaagaagggtgtgaaacacataaggttgccaacacaagttcttttcacaca
actccaaacacatcactgggaatggttcaggcaacgccatccaaagtgcagccatcaccc
accgtgcacacaaaagaagcattaggtttcatcatgaatatgtttcaggctcctacactt
cctgatatttctgatgacaaagatgaatggcaatctctagatcaaaatgaagatgcattt
gaagcccagtttcaaaaaaatgtaaggtcatctggggcttggggagtcaataagatcatc
tcttctttgtcatctgcttttcatgtgtttgaagatggaaacaaagaaaattatggatta
ccacagcctaaaaataaacccacaggagccaggacctttggagaacgctctgtcagcaga
cttccttcaaaaccaaaggaggaagtgcctcatgctgaagagtttttggatgactcaact
gtatggggtattcgctgcaacaaaaccctggcacccagtcctaagagcccaggagacttc
acatctgctgcacaacttgcgtctacaccattccacaagcttccagtggagtcagtgcac
attttagaagataaagaaaatgtggtagcaaaacagtgtacccaggcgactttggattct
tgtgaggaaaacatggtggtgccttcaagggatggaaaattcagtccaattcaagagaaa
agcccaaaacaggccttgtcgtctcacatgtattcagcatccttacttcgtctgagccag
cctgctgcaggtggggtacttacctgtgaggcagagttgggcgttgaggcttgcagactc
acagacactgacgctgccattgcagaagatccaccagatgctattgctgggctccaagca
gaatggatgcagatgagttcacttgggactgttgatgctccaaacttcattgttgggaac
ccatgggatgataagctgattttcaaacttttatctgggctttctaaaccagtgagttcc
tatccaaatacttttgaatggcaatgtaaacttccagccatcaagcccaagactgaattt
caattgggttctaagctggtctatgtccatcaccttcttggagaaggagcctttgcccag
gtgtacgaagctacccagggagatctgaatgatgctaaaaataaacagaaatttgtttta
aaggtccaaaagcctgccaacccctgggaattctacattgggacccagttgatggaaaga
ctaaagccatctatgcagcacatgtttatgaagttctattctgcccacttattccagaat
ggcagtgtattagtaggagagctctacagctatggaacattattaaatgccattaacctc
tataaaaatacccctgaaaaagtgatgcctcaaggtcttgtcatctcttttgctatgaga
atgctttacatgattgagcaagtgcatgactgtgaaatcattcatggagacattaaacca
gacaatttcatacttggaaacggatttttggaacaggatgatgaagatgatttatctgct
ggcttggcactgattgacctgggtcagagtatagatatgaaactttttccaaaaggaact
atattcacagcaaagtgtgaaacatctggttttcagtgtgttgagatgctcagcaacaaa
ccatggaactaccagatcgattactttggggttgctgcaacagtatattgcatgctcttt
ggcacttacatgaaagtgaaaaatgaaggaggagagtgtaagcctgaaggtctttttaga
aggcttcctcatttggatatgtggaatgaattttttcatgttatgttgaatattccagat
tgtcatcatcttccatctttggatttgttaaggcaaaagctgaagaaagtatttcaacaa
cactatactaacaagattagggccctacgtaataggctaattgtactgctcttagaatgt
aagcgttcacgaaaataa

  All links  
Disease (3)   
   OMIM (3)   
Gene (18)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (33)   
   RefSeq(nuc) (5)   
   GenBank (14)   
   EMBL (14)   
3D Structure (9)   
   PDB (9)   
Protein domain (7)   
   Pfam (7)   
All databases (77)   

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