KEGG   Homo sapiens (human): 7030
Entry
7030              CDS       T01001                                 
Symbol
TFE3, MRXSPF, RCCP2, RCCX1, TFEA, bHLHe33
Name
(RefSeq) transcription factor binding to IGHM enhancer 3
  KO
K09105  transcription factor E3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa05202  Transcriptional misregulation in cancer
hsa05211  Renal cell carcinoma
Network
nt06240  Transcription (cancer)
nt06264  Renal cell carcinoma
  Element
N00127  PRCC-TFE3 fusion to transcriptional activation
N00143  ASPL-TFE3 fusion to transcriptional activation
Disease
H00021  Renal cell carcinoma
H00051  Alveolar soft part sarcoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    7030 (TFE3)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    7030 (TFE3)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    7030 (TFE3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7030 (TFE3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Ubiquitous bHLH-ZIP factors
    7030 (TFE3)
SSDB
Motif
Pfam: MITF_TFEB_C_3_N DUF3371 HLH
Other DBs
NCBI-GeneID: 7030
NCBI-ProteinID: NP_006512
OMIM: 314310
HGNC: 11752
Ensembl: ENSG00000068323
UniProt: P19532
Structure
Position
X:complement(49028726..49043357)
AA seq 575 aa
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLD
PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL
MRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPT
GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG
NLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRF
NINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQAN
RSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVG
GGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGA
LSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES
NT seq 1728 nt   +upstreamnt  +downstreamnt
atgtctcatgcggccgaaccagctcgggatggcgtagaggccagcgcggagggccctcga
gccgtgttcgtgctgttggaggagcgcaggccggccgactcggctcagctgctcagcctg
aactctttgcttccggaatccgggattgttgctgacatagaattagaaaacgtccttgat
cctgacagcttctacgagctcaaaagccaacccttaccccttcgctcaagcctcccaata
tcactgcaggccacaccagccaccccagctacactctctgcatcgtcttctgcagggggc
tccaggacccctgccatgtcgtcatcttcttcatcgagggtcttgctgcggcagcagcta
atgcgggcccaggcgcaggagcaggagaggcgtgagcgtcgggaacaggccgccgcggct
cccttccccagtcctgcacctgcctctcctgccatctctgtggttggcgtctctgctggg
ggccacacattgagccgtccaccccctgctcaggtgcccagggaggtgctcaaggtgcag
acccatctggagaacccaacgcgctaccacctgcagcaggcgcgccggcagcaggtgaaa
cagtacctgtccaccacactcgggcccaagctggcttcccaggccctcaccccaccgccg
gggcccgcaagtgcccagccactgcctgcccctgaggctgcccacactaccggccccaca
ggcagtgcgcccaacagccccatggcgctgctcaccatcgggtccagctcagagaaggag
attgatgatgtcattgatgagatcatcagcctggagtccagttacaatgatgaaatgctc
agctatctgcccggaggcaccacaggactgcagctccccagcacgctgcctgtgtcaggg
aatctgcttgatgtgtacagtagtcaaggcgtggccacaccagccatcactgtcagcaac
tcctgcccagctgagctgcccaacatcaaacgggagatctctgagaccgaggcaaaggcc
cttttgaaggaacggcagaagaaagacaatcacaacctaattgagcgtcgcaggcgattc
aacattaacgacaggatcaaggaactgggcactctcatccctaagtccagtgacccggag
atgcgctggaacaagggcaccatcctgaaggcctctgtggattatatccgcaagctgcag
aaggagcagcagcgctccaaagacctggagagccggcagcgatccctggagcaggccaac
cgcagcctgcagctccgaattcaggaactagaactgcaggcccagatccatggcctgcca
gtacctcccactccagggctgctttccttggccacgacttcggcttctgacagcctcaag
ccagagcagctggacattgaggaggagggcaggccaggcgcagcaacgttccatgtaggg
gggggacctgcccagaatgctccccatcagcagccccctgcaccgccctcagatgccctt
ctggacctgcactttcccagcgaccacctgggggacctgggagaccccttccacctgggg
ctggaggacattctgatggaggaggaggagggggtggtgggaggactgtcggggggtgcc
ctgtccccactgcgggctgcctccgatcccctgctctcttcagtgtcccctgctgtctcc
aaggccagcagccgccgcagcagcttcagcatggaagaggagtcctga

  All links  
Disease (3)   
   OMIM (3)   
Gene (19)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (28)   
   RefSeq(nuc) (8)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (61)   

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