KEGG   Homo sapiens (human): 7068
Entry
7068              CDS       T01001                                 
Symbol
THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, THRbeta, THRbeta1, TRb, TRbeta, TRbeta1, Thrbeta2
Name
(RefSeq) thyroid hormone receptor beta
  KO
K08362  thyroid hormone receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04919  Thyroid hormone signaling pathway
Network
nt06322  TRH-TSH-TH signaling
  Element
N00798  Thyroid hormone signaling pathway
Disease
H00249  Thyroid hormone resistance syndrome
Drug target
Dextrothyroxine: D03750
Levothyroxine (DG00510): D08125
Levothyroxine sodium: D01010<JP/US> D11113<US>
Liothyronine (DG01372): D08128 D08129
Liothyronine sodium: D01011<JP/US>
Resmetirom: D11602<US>
Sobetirome: D09381
Thyroid (DG01993): D01012 D06482
Tiratricol: D07214
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    7068 (THRB)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    7068 (THRB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7068 (THRB)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    7068 (THRB)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    7068 (THRB)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1A. Thyroid hormone receptor (THR)
   7068 (THRB)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 7068
NCBI-ProteinID: NP_000452
OMIM: 190160
HGNC: 11799
Ensembl: ENSG00000151090
UniProt: P10828 A0A024R2I8
Structure
Position
3:complement(24117153..24495708)
AA seq 461 aa
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgactcccaacagtatgacagaaaatggccttacagcctgggacaaaccgaagcactgt
ccagaccgagaacacgactggaagctagtaggaatgtctgaagcctgcctacataggaag
agccattcagagaggcgcagcacgttgaaaaatgaacagtcgtcgccacatctcatccag
accacttggactagctcaatattccatctggaccatgatgatgtgaacgaccagagtgtc
tcaagtgcccagaccttccaaacggaggagaagaaatgtaaagggtacatccccagttac
ttagacaaggacgagctctgtgtagtgtgtggtgacaaagccaccgggtatcactaccgc
tgtatcacgtgtgaaggctgcaagggtttctttagaagaaccattcagaaaaatctccat
ccatcctattcctgtaaatatgaaggaaaatgtgtcatagacaaagtcacgcgaaatcag
tgccaggaatgtcgctttaagaaatgcatctatgttggcatggcaacagatttggtgctg
gatgacagcaagaggctggccaagaggaagctgatagaggagaaccgggagaaaagacgg
cgggaagagctgcagaagtccatcgggcacaagccagagcccacagacgaggaatgggag
ctcatcaaaactgtcaccgaagcccatgtggcgaccaacgcccaaggcagccactggaag
caaaaacggaaattcctgccagaagacattggacaagcaccaatagtcaatgccccagaa
ggtggaaaggttgacttggaagccttcagccattttacaaaaatcatcacaccagcaatt
accagagtggtggattttgccaaaaagttgcctatgttttgtgagctgccatgtgaagac
cagatcatcctcctcaaaggctgctgcatggagatcatgtcccttcgcgctgctgtgcgc
tatgacccagaaagtgagactttaaccttgaatggggaaatggcagtgacacggggccag
ctgaaaaatgggggtcttggggtggtgtcagacgccatctttgacctgggcatgtctctg
tcttctttcaacctggatgacactgaagtagccctccttcaggccgtcctgctgatgtct
tcagatcgcccggggcttgcctgtgttgagagaatagaaaagtaccaagatagtttcctg
ctggcctttgaacactatatcaattaccgaaaacaccacgtgacacacttttggccaaaa
ctcctgatgaaggtgacagatctgcggatgataggagcctgccatgccagccgcttcctg
cacatgaaggtggaatgccccacagaactcttcccccctttgttcttggaagtgttcgag
gattag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (1)   
   OMIM (4)   
Drug (12)   
   KEGG DRUG (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (92)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (89)   
DNA sequence (165)   
   RefSeq(nuc) (89)   
   GenBank (38)   
   EMBL (38)   
3D Structure (31)   
   PDB (31)   
Protein domain (2)   
   Pfam (2)   
All databases (326)   

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