KEGG   Homo sapiens (human): 7098
Entry
7098              CDS       T01001                                 
Symbol
TLR3, CD283, IIAE2, IMD83
Name
(RefSeq) toll like receptor 3
  KO
K05401  toll-like receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
hsa04620  Toll-like receptor signaling pathway
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06527  Necroptosis
  Element
N00148  TLR3-IRF7 signaling pathway
N00149  TLR3-IRF3 signaling pathway
N00563  TLR3-NFKB signaling pathway
N00564  HSV US3 to TLR3-NFKB signaling pathway
N01633  TLR3-RIPK3 signaling pathway
Disease
H01563  HIV infection
H02536  Infection-induced acute encephalopathy
Drug target
Rintatolimod: D09661
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    7098 (TLR3)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    7098 (TLR3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    7098 (TLR3)
   05160 Hepatitis C
    7098 (TLR3)
   05171 Coronavirus disease - COVID-19
    7098 (TLR3)
   05164 Influenza A
    7098 (TLR3)
   05168 Herpes simplex virus 1 infection
    7098 (TLR3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    7098 (TLR3)
   05165 Human papillomavirus infection
    7098 (TLR3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    7098 (TLR3)
   04090 CD molecules [BR:hsa04090]
    7098 (TLR3)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   7098 (TLR3)
CD molecules [BR:hsa04090]
 Proteins
  7098 (TLR3)
SSDB
Motif
Pfam: LRR_8 LRR_4 LRR_5 LRR_1 Tlr3_TMD LRR_9 TIR TIR_2 LRRNT LRRCT LRR_NXF1-5
Other DBs
NCBI-GeneID: 7098
NCBI-ProteinID: NP_003256
OMIM: 603029
HGNC: 11849
Ensembl: ENSG00000164342
UniProt: O15455
Structure
Position
4:186069156..186088073
AA seq 904 aa
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH
NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA
FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN
NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK
LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL
NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS
KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP
SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN
NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW
INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV
LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE
DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI
EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
NSVH
NT seq 2715 nt   +upstreamnt  +downstreamnt
atgagacagactttgccttgtatctacttttgggggggccttttgccctttgggatgctg
tgtgcatcctccaccaccaagtgcactgttagccatgaagttgctgactgcagccacctg
aagttgactcaggtacccgatgatctacccacaaacataacagtgttgaaccttacccat
aatcaactcagaagattaccagccgccaacttcacaaggtatagccagctaactagcttg
gatgtaggatttaacaccatctcaaaactggagccagaattgtgccagaaacttcccatg
ttaaaagttttgaacctccagcacaatgagctatctcaactttctgataaaacctttgcc
ttctgcacgaatttgactgaactccatctcatgtccaactcaatccagaaaattaaaaat
aatccctttgtcaagcagaagaatttaatcacattagatctgtctcataatggcttgtca
tctacaaaattaggaactcaggttcagctggaaaatctccaagagcttctattatcaaac
aataaaattcaagcgctaaaaagtgaagaactggatatctttgccaattcatctttaaaa
aaattagagttgtcatcgaatcaaattaaagagttttctccagggtgttttcacgcaatt
ggaagattatttggcctctttctgaacaatgtccagctgggtcccagccttacagagaag
ctatgtttggaattagcaaacacaagcattcggaatctgtctctgagtaacagccagctg
tccaccaccagcaatacaactttcttgggactaaagtggacaaatctcactatgctcgat
ctttcctacaacaacttaaatgtggttggtaacgattcctttgcttggcttccacaacta
gaatatttcttcctagagtataataatatacagcatttgttttctcactctttgcacggg
cttttcaatgtgaggtacctgaatttgaaacggtcttttactaaacaaagtatttccctt
gcctcactccccaagattgatgatttttcttttcagtggctaaaatgtttggagcacctt
aacatggaagataatgatattccaggcataaaaagcaatatgttcacaggattgataaac
ctgaaatacttaagtctatccaactcctttacaagtttgcgaactttgacaaatgaaaca
tttgtatcacttgctcattctcccttacacatactcaacctaaccaagaataaaatctca
aaaatagagagtgatgctttctcttggttgggccacctagaagtacttgacctgggcctt
aatgaaattgggcaagaactcacaggccaggaatggagaggtctagaaaatattttcgaa
atctatctttcctacaacaagtacctgcagctgactaggaactcctttgccttggtccca
agccttcaacgactgatgctccgaagggtggcccttaaaaatgtggatagctctccttca
ccattccagcctcttcgtaacttgaccattctggatctaagcaacaacaacatagccaac
ataaatgatgacatgttggagggtcttgagaaactagaaattctcgatttgcagcataac
aacttagcacggctctggaaacacgcaaaccctggtggtcccatttatttcctaaagggt
ctgtctcacctccacatccttaacttggagtccaacggctttgacgagatcccagttgag
gtcttcaaggatttatttgaactaaagatcatcgatttaggattgaataatttaaacaca
cttccagcatctgtctttaataatcaggtgtctctaaagtcattgaaccttcagaagaat
ctcataacatccgttgagaagaaggttttcgggccagctttcaggaacctgactgagtta
gatatgcgctttaatccctttgattgcacgtgtgaaagtattgcctggtttgttaattgg
attaacgagacccataccaacatccctgagctgtcaagccactacctttgcaacactcca
cctcactatcatgggttcccagtgagactttttgatacatcatcttgcaaagacagtgcc
ccctttgaactctttttcatgatcaataccagtatcctgttgatttttatctttattgta
cttctcatccactttgagggctggaggatatctttttattggaatgtttcagtacatcga
gttcttggtttcaaagaaatagacagacagacagaacagtttgaatatgcagcatatata
attcatgcctataaagataaggattgggtctgggaacatttctcttcaatggaaaaggaa
gaccaatctctcaaattttgtctggaagaaagggactttgaggcgggtgtttttgaacta
gaagcaattgttaacagcatcaaaagaagcagaaaaattatttttgttataacacaccat
ctattaaaagacccattatgcaaaagattcaaggtacatcatgcagttcaacaagctatt
gaacaaaatctggattccattatattggttttccttgaggagattccagattataaactg
aaccatgcactctgtttgcgaagaggaatgtttaaatctcactgcatcttgaactggcca
gttcagaaagaacggataggtgcctttcgtcataaattgcaagtagcacttggatccaaa
aactctgtacattaa

  All links  
Disease (3)   
   OMIM (3)   
Gene (27)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (41)   
   RefSeq(nuc) (1)   
   GenBank (20)   
   EMBL (20)   
3D Structure (20)   
   PDB (20)   
Protein domain (11)   
   Pfam (11)   
All databases (105)   

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