KEGG   Homo sapiens (human): 7098
Entry
7098              CDS       T01001                                 

Gene name
TLR3, CD283, IIAE2
Definition
(RefSeq) toll like receptor 3
  KO
K05401  toll-like receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
hsa04620  Toll-like receptor signaling pathway
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
Network
nt06121  TLR signaling (viruses and bacteria)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06221  TLR signaling
nt06263  Hepatocellular carcinoma
  Element
N00148  TLR3-IRF7 signaling pathway
N00149  TLR3-IRF3 signaling pathway
N00563  TLR3-NFKB signaling pathway
N00564  HSV US3 to TLR3-NFKB signaling pathway
Drug target
Rintatolimod: D09661
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    7098 (TLR3)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    7098 (TLR3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    7098 (TLR3)
   05161 Hepatitis B
    7098 (TLR3)
   05160 Hepatitis C
    7098 (TLR3)
   05168 Herpes simplex virus 1 infection
    7098 (TLR3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    7098 (TLR3)
   05165 Human papillomavirus infection
    7098 (TLR3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    7098 (TLR3)
   04090 CD molecules [BR:hsa04090]
    7098 (TLR3)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   7098 (TLR3)
CD molecules [BR:hsa04090]
 Proteins
  7098 (TLR3)
SSDB
Motif
Pfam: LRR_8 LRR_4 LRR_5 Tlr3_TMD LRR_6 LRR_9 TIR TIR_2 LRRNT LRRCT
Other DBs
NCBI-GeneID: 7098
NCBI-ProteinID: NP_003256
OMIM: 603029
HGNC: 11849
Ensembl: ENSG00000164342
Vega: OTTHUMG00000160345
Pharos: O15455(Tbio)
UniProt: O15455
Structure
PDB: 

Position
4q35.1
AA seq 904 aa
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH
NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA
FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN
NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK
LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL
NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS
KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP
SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN
NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW
INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV
LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE
DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI
EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
NSVH
NT seq 2715 nt   +upstreamnt  +downstreamnt
atgagacagactttgccttgtatctacttttgggggggccttttgccctttgggatgctg
tgtgcatcctccaccaccaagtgcactgttagccatgaagttgctgactgcagccacctg
aagttgactcaggtacccgatgatctacccacaaacataacagtgttgaaccttacccat
aatcaactcagaagattaccagccgccaacttcacaaggtatagccagctaactagcttg
gatgtaggatttaacaccatctcaaaactggagccagaattgtgccagaaacttcccatg
ttaaaagttttgaacctccagcacaatgagctatctcaactttctgataaaacctttgcc
ttctgcacgaatttgactgaactccatctcatgtccaactcaatccagaaaattaaaaat
aatccctttgtcaagcagaagaatttaatcacattagatctgtctcataatggcttgtca
tctacaaaattaggaactcaggttcagctggaaaatctccaagagcttctattatcaaac
aataaaattcaagcgctaaaaagtgaagaactggatatctttgccaattcatctttaaaa
aaattagagttgtcatcgaatcaaattaaagagttttctccagggtgttttcacgcaatt
ggaagattatttggcctctttctgaacaatgtccagctgggtcccagccttacagagaag
ctatgtttggaattagcaaacacaagcattcggaatctgtctctgagtaacagccagctg
tccaccaccagcaatacaactttcttgggactaaagtggacaaatctcactatgctcgat
ctttcctacaacaacttaaatgtggttggtaacgattcctttgcttggcttccacaacta
gaatatttcttcctagagtataataatatacagcatttgttttctcactctttgcacggg
cttttcaatgtgaggtacctgaatttgaaacggtcttttactaaacaaagtatttccctt
gcctcactccccaagattgatgatttttcttttcagtggctaaaatgtttggagcacctt
aacatggaagataatgatattccaggcataaaaagcaatatgttcacaggattgataaac
ctgaaatacttaagtctatccaactcctttacaagtttgcgaactttgacaaatgaaaca
tttgtatcacttgctcattctcccttacacatactcaacctaaccaagaataaaatctca
aaaatagagagtgatgctttctcttggttgggccacctagaagtacttgacctgggcctt
aatgaaattgggcaagaactcacaggccaggaatggagaggtctagaaaatattttcgaa
atctatctttcctacaacaagtacctgcagctgactaggaactcctttgccttggtccca
agccttcaacgactgatgctccgaagggtggcccttaaaaatgtggatagctctccttca
ccattccagcctcttcgtaacttgaccattctggatctaagcaacaacaacatagccaac
ataaatgatgacatgttggagggtcttgagaaactagaaattctcgatttgcagcataac
aacttagcacggctctggaaacacgcaaaccctggtggtcccatttatttcctaaagggt
ctgtctcacctccacatccttaacttggagtccaacggctttgacgagatcccagttgag
gtcttcaaggatttatttgaactaaagatcatcgatttaggattgaataatttaaacaca
cttccagcatctgtctttaataatcaggtgtctctaaagtcattgaaccttcagaagaat
ctcataacatccgttgagaagaaggttttcgggccagctttcaggaacctgactgagtta
gatatgcgctttaatccctttgattgcacgtgtgaaagtattgcctggtttgttaattgg
attaacgagacccataccaacatccctgagctgtcaagccactacctttgcaacactcca
cctcactatcatgggttcccagtgagactttttgatacatcatcttgcaaagacagtgcc
ccctttgaactctttttcatgatcaataccagtatcctgttgatttttatctttattgta
cttctcatccactttgagggctggaggatatctttttattggaatgtttcagtacatcga
gttcttggtttcaaagaaatagacagacagacagaacagtttgaatatgcagcatatata
attcatgcctataaagataaggattgggtctgggaacatttctcttcaatggaaaaggaa
gaccaatctctcaaattttgtctggaagaaagggactttgaggcgggtgtttttgaacta
gaagcaattgttaacagcatcaaaagaagcagaaaaattatttttgttataacacaccat
ctattaaaagacccattatgcaaaagattcaaggtacatcatgcagttcaacaagctatt
gaacaaaatctggattccattatattggttttccttgaggagattccagattataaactg
aaccatgcactctgtttgcgaagaggaatgtttaaatctcactgcatcttgaactggcca
gttcagaaagaacggataggtgcctttcgtcataaattgcaagtagcacttggatccaaa
aactctgtacattaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Network (4)   
   KEGG NETWORK (4)   
Disease (3)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (41)   
   RefSeq(nuc) (1)   
   GenBank (20)   
   EMBL (20)   
Protein domain (10)   
   Pfam (10)   
All databases (104)   

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