KEGG   Homo sapiens (human): 71Help
Entry
71                CDS       T01001                                 

Gene name
ACTG1, ACT, ACTG, DFNA20, DFNA26, HEL-176
Definition
(RefSeq) actin gamma 1
  KO
K05692  actin beta/gamma 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04611  Platelet activation
hsa04670  Leukocyte transendothelial migration
hsa04714  Thermogenesis
hsa04810  Regulation of actin cytoskeleton
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa05100  Bacterial invasion of epithelial cells
hsa05110  Vibrio cholerae infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05164  Influenza A
hsa05205  Proteoglycans in cancer
hsa05225  Hepatocellular carcinoma
hsa05410  Hypertrophic cardiomyopathy (HCM)
hsa05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414  Dilated cardiomyopathy (DCM)
hsa05416  Viral myocarditis
hsa05418  Fluid shear stress and atherosclerosis
Disease
H00604  Deafness, autosomal dominant
H01705  Bilateral sudden sensorineural hearing loss
H02023  Baraitser-Winter syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    71 (ACTG1)
   04390 Hippo signaling pathway
    71 (ACTG1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    71 (ACTG1)
  09143 Cell growth and death
   04210 Apoptosis
    71 (ACTG1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    71 (ACTG1)
   04520 Adherens junction
    71 (ACTG1)
   04530 Tight junction
    71 (ACTG1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    71 (ACTG1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    71 (ACTG1)
   04670 Leukocyte transendothelial migration
    71 (ACTG1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    71 (ACTG1)
   04919 Thyroid hormone signaling pathway
    71 (ACTG1)
  09159 Environmental adaptation
   04714 Thermogenesis
    71 (ACTG1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    71 (ACTG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    71 (ACTG1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    71 (ACTG1)
   05410 Hypertrophic cardiomyopathy (HCM)
    71 (ACTG1)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    71 (ACTG1)
   05414 Dilated cardiomyopathy (DCM)
    71 (ACTG1)
   05416 Viral myocarditis
    71 (ACTG1)
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    71 (ACTG1)
   05130 Pathogenic Escherichia coli infection
    71 (ACTG1)
   05132 Salmonella infection
    71 (ACTG1)
   05131 Shigellosis
    71 (ACTG1)
   05135 Yersinia infection
    71 (ACTG1)
   05100 Bacterial invasion of epithelial cells
    71 (ACTG1)
  09172 Infectious disease: viral
   05164 Influenza A
    71 (ACTG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    71 (ACTG1)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    71 (ACTG1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    71 (ACTG1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    71 (ACTG1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    71 (ACTG1)
   04147 Exosome [BR:hsa04147]
    71 (ACTG1)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Coactivators
    BAF/PBAF complex
     71 (ACTG1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     71 (ACTG1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    TIP60 complex
     71 (ACTG1)
    NuA4 complex
     71 (ACTG1)
  Chromatin remodeling factors
   BAF complex
    71 (ACTG1)
   PBAF complex
    71 (ACTG1)
   SWR1 complex
    71 (ACTG1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Actin cytoskeleton organization
    71 (ACTG1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     71 (ACTG1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   71 (ACTG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Actin
Motif
Other DBs
NCBI-GeneID: 71
NCBI-ProteinID: NP_001186883
OMIM: 102560
HGNC: 144
Ensembl: ENSG00000184009
Vega: OTTHUMG00000177955
Pharos: P63261(Tbio)
UniProt: P63261
Structure
PDB: 

Position
17q25.3
AA seq 375 aa AA seqDB search
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
NT seq 1128 nt NT seq  +upstreamnt  +downstreamnt
atggaagaagagatcgccgcgctggtcattgacaatggctccggcatgtgcaaagctggt
tttgctggggacgacgctccccgagccgtgtttccttccatcgtcgggcgccccagacac
cagggcgtcatggtgggcatgggccagaaggactcctacgtgggcgacgaggcccagagc
aagcgtggcatcctgaccctgaagtaccccattgagcatggcatcgtcaccaactgggac
gacatggagaagatctggcaccacaccttctacaacgagctgcgcgtggccccggaggag
cacccagtgctgctgaccgaggcccccctgaaccccaaggccaacagagagaagatgact
cagattatgtttgagaccttcaacaccccggccatgtacgtggccatccaggccgtgctg
tccctctacgcctctgggcgcaccactggcattgtcatggactctggagacggggtcacc
cacacggtgcccatctacgagggctacgccctcccccacgccatcctgcgtctggacctg
gctggccgggacctgaccgactacctcatgaagatcctcactgagcgaggctacagcttc
accaccacggccgagcgggaaatcgtgcgcgacatcaaggagaagctgtgctacgtcgcc
ctggacttcgagcaggagatggccaccgccgcatcctcctcttctctggagaagagctac
gagctgcccgatggccaggtcatcaccattggcaatgagcggttccggtgtccggaggcg
ctgttccagccttccttcctgggtatggaatcttgcggcatccacgagaccaccttcaac
tccatcatgaagtgtgacgtggacatccgcaaagacctgtacgccaacacggtgctgtcg
ggcggcaccaccatgtacccgggcattgccgacaggatgcagaaggagatcaccgccctg
gcgcccagcaccatgaagatcaagatcatcgcacccccagagcgcaagtactcggtgtgg
atcggtggctccatcctggcctcactgtccaccttccagcagatgtggattagcaagcag
gagtacgacgagtcgggcccctccatcgtccaccgcaaatgcttctaa

  All links  
Ontology (7)   
   KEGG BRITE (7)   
Pathway (27)   
   KEGG PATHWAY (27)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (774)   
   KEGG ORTHOLOGY (1)   
   RefGene (443)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (323)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (57)   
   RefSeq(nuc) (3)   
   GenBank (27)   
   EMBL (27)   
Protein domain (1)   
   Pfam (1)   
All databases (877)   

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