KEGG   Homo sapiens (human): 7155Help
Entry
7155              CDS       T01001                                 

Gene name
TOP2B, TOPIIB, top2beta
Definition
(RefSeq) DNA topoisomerase II beta
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
Drug target
Aclarubicin (DG00699): D01911 D02756
Aldoxorubicin (DG01726): D10383 D10384
Amonafide (DG01268): D10090 D10091
Amrubicin (DG00703): D07100 D08854
Amsacrine: D02321
Becatecarin: D03220
Berubicin hydrochloride: D08871
Crisnatol mesylate: D03602
Daunorubicin (DG00697): D01264 D07776 D10787
Dexrazoxane (DG01162): D03730 D07807
Doxorubicin (DG00696): D01275 D03899
Elsamitrucin: D03977
Epirubicin (DG00698): D02214 D07901
Etoposide (DG00693): D00125 D04107
Fostriecin sodium: D04262
Idarubicin (DG00700): D01747 D08062
Idronoxil: D04498
Ledoxantrone trihydrochloride: D04685
Losoxantrone hydrochloride: D04783
Menogaril: D04914
Mitindomide: D05054
Mitoxantrone (DG00701): D02166 D08224
Pirarubicin (DG00702): D01885 D08386
Piroxantrone hydrochloride: D05510
Pixantrone (DG00704): D05522 D09654
Quarfloxin: D08981
Sobuzoxane: D01404
Teloxantrone hydrochloride: D06059
Teniposide: D02698
Tirapazamine: D06167
Topixantrone: D06190
Valrubicin: D02697
Vosaroxin: D08024
Zorubicin: D06386
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    7155 (TOP2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    7155 (TOP2B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7155 (TOP2B)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     7155 (TOP2B)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Topoisomerases
   7155 (TOP2B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    7155 (TOP2B)
  Centrosome formation and ciliogenesis proteins
   Centriole proteins
    7155 (TOP2B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DNA_topoisoIV TOPRIM_C DTHCT DNA_gyraseB HATPase_c Toprim
Motif
Other DBs
NCBI-GeneID: 7155
NCBI-ProteinID: NP_001317629
OMIM: 126431
HGNC: 11990
Ensembl: ENSG00000077097
Vega: OTTHUMG00000155596
Pharos: Q02880(Tchem)
UniProt: Q02880
Structure
PDB: 

Position
3p24.2
AA seq 1626 aa AA seqDB search
MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVE
SQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK
KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTS
SGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDD
DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK
SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS
SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
GRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDV
DFAMFN
NT seq 4881 nt NT seq  +upstreamnt  +downstreamnt
atggccaagtcgggtggctgcggcgcgggagccggcgtgggcggcggcaacggggcactg
acctgggtgactctttttgatcagaacaatgctgcaaaaaaagaagagtcagaaactgcc
aacaaaaatgattcttcaaagaagttgtctgttgagagagtgtatcagaagaagacacaa
cttgaacacattcttcttcgtcctgatacatatattgggtcagtggagccattgacgcag
ttcatgtgggtgtatgatgaagatgtaggaatgaattgcagggaggttacctttgtgcca
ggtttatacaagatctttgatgaaattttggttaatgctgctgacaataaacagagggat
aagaacatgacttgtattaaagtttctattgatcctgaatctaacattataagcatttgg
aataatgggaaaggcattccagtagtagaacacaaggtagagaaagtttatgttcctgct
ttaatttttggacagcttttaacatccagtaactatgatgatgatgagaaaaaagttaca
ggtggtcgtaatggttatggtgcaaaactttgtaatattttcagtacaaagtttacagta
gaaacagcttgcaaagaatacaaacacagttttaagcagacatggatgaataatatgatg
aagacttctgaagccaaaattaaacattttgatggtgaagattacacatgcataacattc
caaccagatctgtccaaatttaagatggaaaaacttgacaaggatattgtggccctcatg
actagaagggcatatgatttggctggttcgtgtagaggggtcaaggtcatgtttaatgga
aagaaattgcctgtaaatggatttcgcagttatgtagatctttatgtgaaagacaaattg
gatgaaactggggtggccctgaaagttattcatgagcttgcaaatgaaagatgggatgtt
tgtctcacattgagtgaaaaaggattccagcaaatcagctttgtaaatagtattgcaact
acaaaaggtggacggcacgtggattatgtggtagatcaagttgttggtaaactgattgaa
gtagttaagaaaaagaacaaagctggtgtatcagtgaaaccatttcaagtaaaaaaccat
atatgggtttttattaattgccttattgaaaatccaacttttgattctcagactaaggaa
aacatgactctgcagcccaaaagttttgggtctaaatgccagctgtcagaaaaatttttt
aaagcagcctctaattgtggcattgtagaaagtatcctgaactgggtgaaatttaaggct
cagactcagctgaataagaagtgttcatcagtaaaatacagtaaaatcaaaggtattccc
aaactggatgatgctaatgatgctggtggtaaacattccctggagtgtacactgatatta
acagagggagactctgccaaatcactggctgtgtctggattaggtgtgattggacgagac
agatacggagtttttccactcaggggcaaaattcttaatgtacgggaagcttctcataaa
cagatcatggaaaatgctgaaataaataatattattaaaatagttggtctacaatataag
aaaagttacgatgatgcagaatctctgaaaaccttacgctatggaaagattatgattatg
accgatcaggatcaagatggttctcacataaaaggcctgcttattaatttcatccatcac
aattggccatcacttttgaagcatggttttcttgaagagttcattactcctattgtaaag
gcaagcaaaaataagcaggaactttccttctacagtattcctgaatttgacgaatggaaa
aaacatatagaaaaccagaaagcctggaaaataaagtactataaaggattgggtactagt
acagctaaagaagcaaaggaatattttgctgatatggaaaggcatcgcatcttgtttaga
tatgctggtcctgaagatgatgctgccattaccttggcatttagtaagaagaagattgat
gacagaaaagaatggttaacaaattttatggaagaccggagacagcgtaggctacatggc
ttaccagagcaatttttatatggtactgcaacaaagcatttgacttataatgatttcatc
aacaaggaattgattctcttctcaaactcagacaatgaaagatctataccatctcttgtt
gatggctttaaacctggccagcggaaagttttatttacctgtttcaagaggaatgataaa
cgtgaagtaaaagttgcccagttggctggctctgttgctgagatgtcggcttatcatcat
ggagaacaagcattgatgatgactattgtgaatttggctcagaactttgtgggaagtaac
aacattaacttgcttcagcctattggtcagtttggaactcggcttcatggtggcaaagat
gctgcaagccctcgttatattttcacaatgttaagcactttagcaaggctactttttcct
gctgtggatgacaacctccttaagttcctttatgatgataatcaacgtgtagagcctgag
tggtatattcctataattcccatggttttaataaatggtgctgagggcattggtactgga
tgggcttgtaaactacccaactatgatgctagggaaattgtgaacaatgtcagacgaatg
ctagatggcctggatcctcatcccatgcttccaaactacaaaaactttaaaggcacgatt
caagaacttggtcaaaaccagtatgcagtcagtggtgaaatatttgtagtggacagaaac
acagtagaaattacagagcttccagttagaacttggacacaggtatataaagaacaggtt
ttagaacctatgctaaatggaacagataaaacaccagcattaatttctgattataaagaa
tatcatactgacacaactgtgaaatttgtggtgaaaatgactgaagagaaactagcacaa
gcagaagctgctggactgcataaagtttttaaacttcaaactactcttacttgtaattcc
atggtactttttgatcatatgggatgtctgaagaaatatgaaactgtgcaagacattctg
aaagaattctttgatttacgattaagttattacggtttacgtaaggagtggcttgtggga
atgttgggagcagaatctacaaagcttaacaatcaagcccgtttcattttagagaagata
caagggaaaattactatagagaataggtcaaagaaagatttgattcaaatgttagtccag
agaggttatgaatctgacccagtgaaagcctggaaagaagcacaagaaaaggcagcagaa
gaggatgaaacacaaaaccagcatgatgatagttcctccgattcaggaactccttcaggc
ccagattttaattatattttaaatatgtctctgtggtctcttactaaagaaaaagttgaa
gaactgattaaacagagagatgcaaaagggcgagaggtcaatgatcttaaaagaaaatct
ccttcagatctttggaaagaggatttagcggcatttgttgaagaactggataaagtggaa
tctcaagaacgagaagatgttctggctggaatgtctggaaaagcaattaaaggtaaagtt
ggcaaacctaaggtgaagaaactccagttggaagagacaatgccctcaccttatggcaga
agaataattcctgaaattacagctatgaaggcagatgccagcaaaaagttgctgaagaag
aagaagggtgatcttgatactgcagcagtaaaagtggaatttgatgaagaattcagtgga
gcaccagtagaaggtgcaggagaagaggcattgactccatcagttcctataaataaaggt
cccaaacctaagagggagaagaaggagcctggtaccagagtgagaaaaacacctacatca
tctggtaaacctagtgcaaagaaagtgaagaaacggaatccttggtcagatgatgaatcc
aagtcagaaagtgatttggaagaaacagaacctgtggttattccaagagattctttgctt
aggagagcagcagccgaaagacctaaatacacatttgatttctcagaagaagaggatgat
gatgctgatgatgatgatgatgacaataatgatttagaggaattgaaagttaaagcatct
cccataacaaatgatggggaagatgaatttgttccttcagatgggttagataaagatgaa
tatacattttcaccaggcaaatcaaaagccactccagaaaaatctttgcatgacaaaaaa
agtcaggattttggaaatctcttctcatttccttcatattctcagaagtcagaagatgat
tcagctaaatttgacagtaatgaagaagattctgcttctgttttttcaccatcatttggt
ctgaaacagacagataaagttccaagtaaaacggtagctgctaaaaagggaaaaccgtct
tcagatacagtccctaagcccaagagagccccaaaacagaagaaagtagtagaggctgta
aactctgactcggattcagaatttggcattccaaagaagactacaacaccaaaaggtaaa
ggccgaggggcaaagaaaaggaaagcatctggctctgaaaatgaaggcgattataaccct
ggcaggaaaacatccaaaacaacaagcaagaaaccgaagaagacatcttttgatcaggat
tcagatgtggacatcttcccctcagacttccctactgagccaccttctctgccacgaacc
ggtcgggctaggaaagaagtaaaatattttgcagagtctgatgaagaagaagatgatgtt
gattttgcaatgtttaattaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (48)   
   KEGG DRUG (48)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (34)   
   RefSeq(nuc) (4)   
   GenBank (15)   
   EMBL (15)   
Protein domain (6)   
   Pfam (6)   
All databases (124)   

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