KEGG   Homo sapiens (human): 7155
Entry
7155              CDS       T01001                                 
Symbol
TOP2B, BILU, TOPIIB, top2beta
Name
(RefSeq) DNA topoisomerase II beta
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
Disease
H02574  BILU syndrome
Drug target
Aclarubicin (DG00699): D01911<JP> D02756
Aldoxorubicin (DG01726): D10383 D10384
Amonafide (DG01268): D10090 D10091
Amrubicin (DG00703): D07100<JP> D08854
Amsacrine: D02321
Becatecarin: D03220
Berubicin hydrochloride: D08871
Crisnatol mesylate: D03602
Daunorubicin (DG00697): D01264<JP/US> D07776 D10787
Dexrazoxane (DG01162): D03730<JP/US> D07807<US>
Doxorubicin (DG00696): D01275<JP/US> D03899
Elsamitrucin: D03977
Epirubicin (DG00698): D02214<JP/US> D07901
Etoposide (DG00693): D00125<JP/US> D04107<US>
Fostriecin sodium: D04262
Idarubicin (DG00700): D01747<JP/US> D08062
Idronoxil: D04498
Ledoxantrone trihydrochloride: D04685
Losoxantrone hydrochloride: D04783
Menogaril: D04914
Mitindomide: D05054
Mitoxantrone (DG00701): D02166<JP/US> D08224
Naxtarubicin: D12844
Pirarubicin (DG00702): D01885 D08386<JP>
Piroxantrone hydrochloride: D05510
Pixantrone (DG00704): D05522 D09654
Quarfloxin: D08981
Sobuzoxane: D01404<JP>
Teloxantrone hydrochloride: D06059
Teniposide: D02698
Tirapazamine: D06167
Topixantrone: D06190
Valrubicin: D02697<US>
Vosaroxin: D08024
Zorubicin: D06386
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    7155 (TOP2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    7155 (TOP2B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7155 (TOP2B)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     7155 (TOP2B)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Topoisomerases
   7155 (TOP2B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    7155 (TOP2B)
  Centrosome formation proteins
   Centriole proteins
    7155 (TOP2B)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim HATPase_c DUF7180 Microp_apicomplexa_20
Other DBs
NCBI-GeneID: 7155
NCBI-ProteinID: NP_001317629
OMIM: 126431
HGNC: 11990
Ensembl: ENSG00000077097
UniProt: Q02880
Structure
Position
3:complement(25597905..25664907)
AA seq 1626 aa
MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVE
SQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK
KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTS
SGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDD
DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK
SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS
SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
GRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDV
DFAMFN
NT seq 4881 nt   +upstreamnt  +downstreamnt
atggccaagtcgggtggctgcggcgcgggagccggcgtgggcggcggcaacggggcactg
acctgggtgactctttttgatcagaacaatgctgcaaaaaaagaagagtcagaaactgcc
aacaaaaatgattcttcaaagaagttgtctgttgagagagtgtatcagaagaagacacaa
cttgaacacattcttcttcgtcctgatacatatattgggtcagtggagccattgacgcag
ttcatgtgggtgtatgatgaagatgtaggaatgaattgcagggaggttacctttgtgcca
ggtttatacaagatctttgatgaaattttggttaatgctgctgacaataaacagagggat
aagaacatgacttgtattaaagtttctattgatcctgaatctaacattataagcatttgg
aataatgggaaaggcattccagtagtagaacacaaggtagagaaagtttatgttcctgct
ttaatttttggacagcttttaacatccagtaactatgatgatgatgagaaaaaagttaca
ggtggtcgtaatggttatggtgcaaaactttgtaatattttcagtacaaagtttacagta
gaaacagcttgcaaagaatacaaacacagttttaagcagacatggatgaataatatgatg
aagacttctgaagccaaaattaaacattttgatggtgaagattacacatgcataacattc
caaccagatctgtccaaatttaagatggaaaaacttgacaaggatattgtggccctcatg
actagaagggcatatgatttggctggttcgtgtagaggggtcaaggtcatgtttaatgga
aagaaattgcctgtaaatggatttcgcagttatgtagatctttatgtgaaagacaaattg
gatgaaactggggtggccctgaaagttattcatgagcttgcaaatgaaagatgggatgtt
tgtctcacattgagtgaaaaaggattccagcaaatcagctttgtaaatagtattgcaact
acaaaaggtggacggcacgtggattatgtggtagatcaagttgttggtaaactgattgaa
gtagttaagaaaaagaacaaagctggtgtatcagtgaaaccatttcaagtaaaaaaccat
atatgggtttttattaattgccttattgaaaatccaacttttgattctcagactaaggaa
aacatgactctgcagcccaaaagttttgggtctaaatgccagctgtcagaaaaatttttt
aaagcagcctctaattgtggcattgtagaaagtatcctgaactgggtgaaatttaaggct
cagactcagctgaataagaagtgttcatcagtaaaatacagtaaaatcaaaggtattccc
aaactggatgatgctaatgatgctggtggtaaacattccctggagtgtacactgatatta
acagagggagactctgccaaatcactggctgtgtctggattaggtgtgattggacgagac
agatacggagtttttccactcaggggcaaaattcttaatgtacgggaagcttctcataaa
cagatcatggaaaatgctgaaataaataatattattaaaatagttggtctacaatataag
aaaagttacgatgatgcagaatctctgaaaaccttacgctatggaaagattatgattatg
accgatcaggatcaagatggttctcacataaaaggcctgcttattaatttcatccatcac
aattggccatcacttttgaagcatggttttcttgaagagttcattactcctattgtaaag
gcaagcaaaaataagcaggaactttccttctacagtattcctgaatttgacgaatggaaa
aaacatatagaaaaccagaaagcctggaaaataaagtactataaaggattgggtactagt
acagctaaagaagcaaaggaatattttgctgatatggaaaggcatcgcatcttgtttaga
tatgctggtcctgaagatgatgctgccattaccttggcatttagtaagaagaagattgat
gacagaaaagaatggttaacaaattttatggaagaccggagacagcgtaggctacatggc
ttaccagagcaatttttatatggtactgcaacaaagcatttgacttataatgatttcatc
aacaaggaattgattctcttctcaaactcagacaatgaaagatctataccatctcttgtt
gatggctttaaacctggccagcggaaagttttatttacctgtttcaagaggaatgataaa
cgtgaagtaaaagttgcccagttggctggctctgttgctgagatgtcggcttatcatcat
ggagaacaagcattgatgatgactattgtgaatttggctcagaactttgtgggaagtaac
aacattaacttgcttcagcctattggtcagtttggaactcggcttcatggtggcaaagat
gctgcaagccctcgttatattttcacaatgttaagcactttagcaaggctactttttcct
gctgtggatgacaacctccttaagttcctttatgatgataatcaacgtgtagagcctgag
tggtatattcctataattcccatggttttaataaatggtgctgagggcattggtactgga
tgggcttgtaaactacccaactatgatgctagggaaattgtgaacaatgtcagacgaatg
ctagatggcctggatcctcatcccatgcttccaaactacaaaaactttaaaggcacgatt
caagaacttggtcaaaaccagtatgcagtcagtggtgaaatatttgtagtggacagaaac
acagtagaaattacagagcttccagttagaacttggacacaggtatataaagaacaggtt
ttagaacctatgctaaatggaacagataaaacaccagcattaatttctgattataaagaa
tatcatactgacacaactgtgaaatttgtggtgaaaatgactgaagagaaactagcacaa
gcagaagctgctggactgcataaagtttttaaacttcaaactactcttacttgtaattcc
atggtactttttgatcatatgggatgtctgaagaaatatgaaactgtgcaagacattctg
aaagaattctttgatttacgattaagttattacggtttacgtaaggagtggcttgtggga
atgttgggagcagaatctacaaagcttaacaatcaagcccgtttcattttagagaagata
caagggaaaattactatagagaataggtcaaagaaagatttgattcaaatgttagtccag
agaggttatgaatctgacccagtgaaagcctggaaagaagcacaagaaaaggcagcagaa
gaggatgaaacacaaaaccagcatgatgatagttcctccgattcaggaactccttcaggc
ccagattttaattatattttaaatatgtctctgtggtctcttactaaagaaaaagttgaa
gaactgattaaacagagagatgcaaaagggcgagaggtcaatgatcttaaaagaaaatct
ccttcagatctttggaaagaggatttagcggcatttgttgaagaactggataaagtggaa
tctcaagaacgagaagatgttctggctggaatgtctggaaaagcaattaaaggtaaagtt
ggcaaacctaaggtgaagaaactccagttggaagagacaatgccctcaccttatggcaga
agaataattcctgaaattacagctatgaaggcagatgccagcaaaaagttgctgaagaag
aagaagggtgatcttgatactgcagcagtaaaagtggaatttgatgaagaattcagtgga
gcaccagtagaaggtgcaggagaagaggcattgactccatcagttcctataaataaaggt
cccaaacctaagagggagaagaaggagcctggtaccagagtgagaaaaacacctacatca
tctggtaaacctagtgcaaagaaagtgaagaaacggaatccttggtcagatgatgaatcc
aagtcagaaagtgatttggaagaaacagaacctgtggttattccaagagattctttgctt
aggagagcagcagccgaaagacctaaatacacatttgatttctcagaagaagaggatgat
gatgctgatgatgatgatgatgacaataatgatttagaggaattgaaagttaaagcatct
cccataacaaatgatggggaagatgaatttgttccttcagatgggttagataaagatgaa
tatacattttcaccaggcaaatcaaaagccactccagaaaaatctttgcatgacaaaaaa
agtcaggattttggaaatctcttctcatttccttcatattctcagaagtcagaagatgat
tcagctaaatttgacagtaatgaagaagattctgcttctgttttttcaccatcatttggt
ctgaaacagacagataaagttccaagtaaaacggtagctgctaaaaagggaaaaccgtct
tcagatacagtccctaagcccaagagagccccaaaacagaagaaagtagtagaggctgta
aactctgactcggattcagaatttggcattccaaagaagactacaacaccaaaaggtaaa
ggccgaggggcaaagaaaaggaaagcatctggctctgaaaatgaaggcgattataaccct
ggcaggaaaacatccaaaacaacaagcaagaaaccgaagaagacatcttttgatcaggat
tcagatgtggacatcttcccctcagacttccctactgagccaccttctctgccacgaacc
ggtcgggctaggaaagaagtaaaatattttgcagagtctgatgaagaagaagatgatgtt
gattttgcaatgtttaattaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (20)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (38)   
   RefSeq(nuc) (8)   
   GenBank (15)   
   EMBL (15)   
3D Structure (16)   
   PDB (16)   
Protein domain (8)   
   Pfam (8)   
All databases (94)   

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