KEGG   Homo sapiens (human): 7156
Entry
7156              CDS       T01001                                 

Gene name
TOP3A, MGRISCE2, PEOB5, TOP3, ZGRF7
Definition
(RefSeq) DNA topoisomerase III alpha
  KO
K03165  DNA topoisomerase III [EC:5.6.2.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Disease
H02492  Microcephaly, growth restriction, and increased sister chromatid exchange
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    7156 (TOP3A)
   03460 Fanconi anemia pathway
    7156 (TOP3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    7156 (TOP3A)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    7156 (TOP3A)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.1  DNA topoisomerase
     7156 (TOP3A)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Topoisomerases
   7156 (TOP3A)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Bloom's syndrome complex (BTR)
     7156 (TOP3A)
   FA (Fanconi anemia) pathway
     7156 (TOP3A)
SSDB
Motif
Pfam: Topoisom_bac zf-GRF Toprim zf-C4_Topoisom zf-C2H2_10
Other DBs
NCBI-GeneID: 7156
NCBI-ProteinID: NP_004609
OMIM: 601243
HGNC: 11992
Ensembl: ENSG00000177302
Vega: OTTHUMG00000059391
Pharos: Q13472(Tbio)
UniProt: Q13472
Structure
PDB: 
4CGY 4CHT

Position
17p11.2
AA seq 1001 aa
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRR
REGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEK
YCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSE
ITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLIS
YGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLY
QLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYI
SYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT
KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDV
YPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE
HIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKK
DKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQ
CNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKF
KRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQH
PQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNG
GSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCS
QPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLES
EARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
NT seq 3006 nt   +upstreamnt  +downstreamnt
atgatctttcctgtcgcccgctacgcgctccggtggctgcgacggcccgaagaccgtgcc
ttttcccgcgccgccatggagatggccctccgaggcgtgcggaaagtcctctgtgtggcc
gaaaaaaacgacgcggccaaggggatcgccgacctgctgtcaaacggtcgcatgaggcgg
agagaaggactttcaaaattcaacaagatctatgaatttgattatcatctgtatggccag
aatgttaccatggtaatgacttcagtttctggacatttactggctcatgatttccagatg
cagtttcgaaaatggcagagctgcaaccctcttgtcctctttgaagcagaaattgaaaag
tactgcccagagaattttgtagacatcaagaaaactttggaacgagagactcgccagtgc
caggctctggtgatctggactgactgtgatagagaaggcgaaaacatcgggtttgagatt
atccacgtgtgtaaggctgtaaagcccaatctgcaggtgttgcgagcccgattctctgag
atcacaccccatgccgtcaggacagcttgtgaaaacctgaccgagcctgatcagagggtg
agcgatgctgtggatgtgaggcaggagctggacctgaggattggagctgcctttactagg
ttccagaccctgcggcttcagaggatttttcctgaggtgctggcagagcagctcatcagt
tacggcagctgccagttccccacactgggctttgtggtggagcggttcaaagccattcag
gcttttgtaccagaaatcttccacagaattaaagtaactcatgaccacaaagatggtatc
gtagaattcaactggaaaaggcatcgactctttaaccacacggcttgcctagttctctat
cagttgtgtgtggaggatcccatggcaactgtggtagaggtcagatctaagcccaagagc
aagtggcggcctcaagccttggacactgtggagcttgagaagctggcttctcgaaagttg
agaataaatgctaaagaaaccatgaggattgctgagaagctctacactcaagggtacatc
agctatccccgaacagaaacaaacatttttcccagagacttaaacctgacggtgttggtg
gaacagcagacccccgatccacgctggggggcctttgcccagagcattctagagcggggt
ggtcccaccccacgcaatgggaacaagtctgaccaagctcaccctcccattcaccccacc
aaatacaccaacaacttacagggagatgaacagcgactgtacgagtttattgttcgccat
ttcctggcttgctgctcccaggatgctcaggggcaggagaccacagtggagatcgacatc
gctcaggaacgctttgtggcccatggcctcatgattctggcccgaaactatctggatgtg
tatccatatgatcactggagtgacaagatcctccctgtctatgagcaaggatcccacttt
cagcccagcaccgtggagatggtggacggggagaccagcccacccaagctgctcaccgag
gccgacctcattgccctcatggagaagcatggcattggtacggatgccactcatgcggag
cacatcgagaccatcaaagcccggatgtacgtgggcctcaccccagacaagcggttcctc
cctgggcacctgggcatgggacttgtggaaggttatgattccatgggctatgaaatgtct
aagcctgacctccgggctgaactggaagctgatctgaagctgatctgtgatggcaaaaag
gacaaatttgtggttctaaggcagcaagtgcagaaatacaagcaggttttcattgaagcg
gtggctaaagcaaagaaattggacgaggccttggcccagtactttgggaatgggacagag
ttggcccagcaagaagatatctacccagccatgccagagcccatcaggaagtgcccacag
tgcaacaaggacatggtccttaagaccaagaagaatggcgggttctacctcagctgcatg
ggtttcccagagtgtcgctcagctgtgtggcttcctgactcggtgctggaggccagcagg
gacagcagtgtgtgtccagtttgtcagccacaccctgtgtacaggttaaagttaaagttt
aagcgcggtagccttcccccgaccatgcctctggagtttgtttgctgcatcggcggatgc
gacgacaccctgagggagatcctggacctgagattttcagggggcccccccagggctagc
cagccctctggccgcctgcaggctaaccagtccctgaacaggatggacaacagccagcac
ccccagcctgctgacagcagacagactgggtcctcaaaggctctggcccagaccctccca
ccacccacggctgctggtgaaagcaattctgtgacctgcaactgtggccaggaggctgtg
ctgctcactgtccgtaaggagggccccaaccggggccggcagttctttaagtgcaacgga
ggtagctgcaacttcttcctgtgggcagacagccccaatccgggagcaggagggcctcct
gccttggcatatagacccctgggcgcctccctgggatgcccaccaggcccagggatccac
ctaggtgggtttggcaaccctggtgatggcagtggtagtggcacatcctgcctttgcagc
cagccctccgtcacacggactgtgcagaaggatggacccaacaaggggcgccagttccac
acatgtgccaagccgagagagcagcagtgtggctttttccagtgggtcgatgagaacacc
gctccagggacttctggagccccgtcctggacaggagacagaggaagaaccctggagtcg
gaagccagaagcaaaaggccccgggccagttcctcagacatggggtccacagcaaagaaa
ccccggaaatgcagcctttgccaccagcctggacacacccgtcccttttgtcctcagaac
agatga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (29)   
   RefSeq(nuc) (5)   
   GenBank (12)   
   EMBL (12)   
Protein domain (5)   
   Pfam (5)   
All databases (77)   

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