KEGG   Homo sapiens (human): 7185
Entry
7185              CDS       T01001                                 
Symbol
TRAF1, EBI6, MGC:10353
Name
(RefSeq) TNF receptor associated factor 1
  KO
K03172  TNF receptor-associated factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04668  TNF signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05203  Viral carcinogenesis
hsa05222  Small cell lung cancer
Network
nt06240  Transcription (cancer)
  Element
N00123  Amplified REL to transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    7185 (TRAF1)
   04668 TNF signaling pathway
    7185 (TRAF1)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    7185 (TRAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7185 (TRAF1)
   05202 Transcriptional misregulation in cancer
    7185 (TRAF1)
   05203 Viral carcinogenesis
    7185 (TRAF1)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    7185 (TRAF1)
SSDB
Motif
Pfam: TRAF-mep_MATH MATH_2 TRAF_BIRC3_bd PilJ XLF_CC
Other DBs
NCBI-GeneID: 7185
NCBI-ProteinID: NP_001177874
OMIM: 601711
HGNC: 12031
Ensembl: ENSG00000056558
UniProt: Q13077
Structure
Position
9:complement(120902393..120929171)
AA seq 416 aa
MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGE
DLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLL
GFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQH
FMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQ
QTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAK
YGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAID
AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST
NT seq 1251 nt   +upstreamnt  +downstreamnt
atggcctccagctcaggcagcagtcctcgcccggcccctgatgagaatgagtttcccttt
gggtgccctcccaccgtctgccaggacccaaaggagcccagggctctctgctgtgcaggc
tgtctctctgagaacccgaggaatggcgaggatcagatctgccccaaatgcagaggggaa
gacctccagtctataagcccaggaagccgtcttcgaactcaggagaaggctcaccccgag
gtggctgaggctggaattgggtgcccctttgcaggtgtcggctgctccttcaagggaagc
ccacagtctgtgcaagagcatgaggtcacctcccagacctcccacctaaacctgctgttg
gggttcatgaaacagtggaaggcccggctgggctgtggcctggagtctgggcccatggcc
ctggagcagaacctgtcagacctgcagctgcaggcagccgtggaagtggcgggggacctg
gaggtcgattgctaccgggcaccctgctccgagagccaggaggagctggccctgcagcac
ttcatgaaggagaagcttctggctgagctggaggggaagctgcgtgtgtttgagaacatt
gttgctgtcctcaacaaggaggtggaggcctcccacctggccctggccacctctatccac
cagagccagctggaccgtgagcgcatcctgagcttggagcagagggtggtggagcttcag
cagaccctggcccagaaagaccaggccctgggcaagctggagcagagcttgcgcctcatg
gaggaggcctccttcgatggcactttcctgtggaagatcaccaatgtcaccaggcggtgc
catgagtcggcctgtggcaggaccgtcagcctcttctccccagccttctacactgccaag
tatggctacaagttgtgcctgcggctgtacctgaatggagatggcactggaaagagaacc
catctgtcgctcttcatcgtgatcatgagaggggagtatgatgcgctgctgccgtggccc
ttccggaacaaggtcaccttcatgctgctggaccagaacaaccgtgagcacgccattgac
gccttccggcctgacctaagctcagcgtccttccagaggccccagagtgaaaccaacgtg
gccagtggatgcccactcttcttccccctcagcaaactgcagtcacccaagcacgcctac
gtgaaggacgacacaatgttcctcaagtgcattgtggagaccagcacttag

  All links  
Disease (1)   
   OMIM (1)   
Gene (9)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (21)   
   RefSeq(nuc) (5)   
   GenBank (8)   
   EMBL (8)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (46)   

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KEGG   Homo sapiens (human): 7186
Entry
7186              CDS       T01001                                 
Symbol
TRAF2, MGC:45012, RNF117, TRAP, TRAP3
Name
(RefSeq) TNF receptor associated factor 2
  KO
K03173  TNF receptor-associated factor 2 [EC:2.3.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04137  Mitophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05160  Hepatitis C
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05222  Small cell lung cancer
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06223  TNF signaling (cancer)
nt06231  Apoptosis (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
nt06527  Necroptosis
nt06534  Unfolded protein response
  Element
N00145  Extrinsic apoptotic pathway
N00151  TNF-NFKB signaling pathway
N00173  KSHV K15 to TNF-NFKB signaling pathway
N00174  KSHV vFLIP to TNF-NFKB signaling pathway
N00441  HIV gp120 to TNF-NFKB signaling pathway
N00442  HIV Nef to TNF-NFKB signaling pathway
N00444  TNF-p38 signaling pathway
N00446  TNF-JNK signaling pathway
N00505  CD40-NFKB signaling pathway
N00525  HCV NS5A to TNF-NFKB signaling pathway
N00559  LIGHT-HVEM-NFKB signaling pathway
N00560  HSV gD to HVEM-NFKB signaling pathway
N00859  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00928  Escherichia NleB to TNF-NFKB signaling pathway
N00944  Shigella OspI to TNF-NFKB signaling pathway
N01013  IRE1a-JNK signaling pathway
N01113  Salmonella SseK1 to TNF-NFKB signaling pathway
N01621  TNF-RIPK1/3 signaling pathway
N01796  TNFSF4-TNFRSF4 signaling pathway
N01798  TNFSF11-TNFRSF11A signaling pathway
N01799  CD70-CD27 signaling pathway
N01801  TNFSF13-TNFRSF13B/C signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    7186 (TRAF2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7186 (TRAF2)
   04064 NF-kappa B signaling pathway
    7186 (TRAF2)
   04668 TNF signaling pathway
    7186 (TRAF2)
   04071 Sphingolipid signaling pathway
    7186 (TRAF2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    7186 (TRAF2)
  09143 Cell growth and death
   04210 Apoptosis
    7186 (TRAF2)
   04217 Necroptosis
    7186 (TRAF2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    7186 (TRAF2)
   04622 RIG-I-like receptor signaling pathway
    7186 (TRAF2)
   04657 IL-17 signaling pathway
    7186 (TRAF2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    7186 (TRAF2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7186 (TRAF2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7186 (TRAF2)
   05203 Viral carcinogenesis
    7186 (TRAF2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    7186 (TRAF2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    7186 (TRAF2)
   05160 Hepatitis C
    7186 (TRAF2)
   05168 Herpes simplex virus 1 infection
    7186 (TRAF2)
   05163 Human cytomegalovirus infection
    7186 (TRAF2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    7186 (TRAF2)
   05169 Epstein-Barr virus infection
    7186 (TRAF2)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7186 (TRAF2)
   05132 Salmonella infection
    7186 (TRAF2)
   05131 Shigellosis
    7186 (TRAF2)
   05135 Yersinia infection
    7186 (TRAF2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7186 (TRAF2)
   05014 Amyotrophic lateral sclerosis
    7186 (TRAF2)
   05016 Huntington disease
    7186 (TRAF2)
   05017 Spinocerebellar ataxia
    7186 (TRAF2)
   05022 Pathways of neurodegeneration - multiple diseases
    7186 (TRAF2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7186 (TRAF2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    7186 (TRAF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    7186 (TRAF2)
   04121 Ubiquitin system [BR:hsa04121]
    7186 (TRAF2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     7186 (TRAF2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     7186 (TRAF2)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    7186 (TRAF2)
SSDB
Motif
Pfam: TRAF-mep_MATH MATH_2 TRAF_BIRC3_bd zf-TRAF TRAF2_zf zf-C3HC4 TRAF3_RING zf-C3HC4_2 zf-RING_6 MATH SlyX
Other DBs
NCBI-GeneID: 7186
NCBI-ProteinID: NP_066961
OMIM: 601895
HGNC: 12032
Ensembl: ENSG00000127191
UniProt: Q12933
Structure
Position
9:136881958..136926607
AA seq 501 aa
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLAS
ILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKE
YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE
VCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWL
REHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA
EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISD
FARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDA
LLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEA
KNSYVRDDAIFIKAIVDLTGL
NT seq 1506 nt   +upstreamnt  +downstreamnt
atggctgcagctagcgtgaccccccctggctccctggagttgctacagcccggcttctcc
aagaccctcctggggaccaagctggaagccaagtacctgtgctccgcctgcagaaacgtc
ctccgcaggcccttccaggcgcagtgtggccaccggtactgctccttctgcctggccagc
atcctcagctctgggcctcagaactgtgctgcctgtgttcacgagggcatatatgaagaa
ggcatttctattttagaaagcagttcggccttcccagataatgctgcccgcagggaggtg
gagagcctgccggccgtctgtcccagtgatggatgcacctggaaggggaccctgaaagaa
tacgagagctgccacgaaggccgctgcccgctcatgctgaccgaatgtcccgcgtgcaaa
ggcctggtccgccttggtgaaaaggagcgccacctggagcacgagtgcccggagagaagc
ctgagctgccggcattgccgggcaccctgctgcggagcagacgtgaaggcgcaccacgag
gtctgccccaagttccccttaacttgtgacggctgcggcaagaagaagatcccccgggag
aagtttcaggaccacgtcaagacttgtggcaagtgtcgagtcccttgcagattccacgcc
atcggctgcctcgagacggtagagggtgagaaacagcaggagcacgaggtgcagtggctg
cgggagcacctggccatgctactgagctcggtgctggaggcaaagcccctcttgggagac
cagagccacgcggggtcagagctcctgcagaggtgcgagagcctggagaagaagacggcc
acttttgagaacattgtctgcgtcctgaaccgggaggtggagagggtggccatgactgcc
gaggcctgcagccggcagcaccggctggaccaagacaagattgaagccctgagtagcaag
gtgcagcagctggagaggagcattggcctcaaggacctggcgatggctgacttggagcag
aaggtcttggagatggaggcatccacctacgatggggtcttcatctggaagatctcagac
ttcgccaggaagcgccaggaagctgtggctggccgcatacccgccatcttctccccagcc
ttctacaccagcaggtacggctacaagatgtgtctgcgtatctacctgaacggcgacggc
accgggcgaggaacacacctgtccctcttctttgtggtgatgaagggcccgaatgacgcc
ctgctgcggtggcccttcaaccagaaggtgaccttaatgctgctcgaccagaataaccgg
gagcacgtgattgacgccttcaggcccgacgtgacttcatcctcttttcagaggccagtc
aacgacatgaacatcgcaagcggctgccccctcttctgccccgtctccaagatggaggca
aagaattcctacgtgcgggacgatgccatcttcatcaaggccattgtggacctgacaggg
ctctaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (31)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (33)   
   RefSeq(nuc) (9)   
   GenBank (12)   
   EMBL (12)   
3D Structure (15)   
   PDB (15)   
Protein domain (11)   
   Pfam (11)   
All databases (102)   

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