KEGG   Homo sapiens (human): 7253Help
Entry
7253              CDS       T01001                                 

Gene name
TSHR, CHNG1, LGR3, hTSHR-I
Definition
(RefSeq) thyroid stimulating hormone receptor
  KO
K04249  thyrotropin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04918  Thyroid hormone synthesis
hsa04923  Regulation of lipolysis in adipocytes
hsa05320  Autoimmune thyroid disease
Network
nt06322  TRH-TSH-TH signaling
  Element
N00782  TSH-TG signaling pathway
N00783  Mutation-inactivated TSH to TSH-TG signaling pathway
N00784  Mutation-inactivated TSHR to TSH-TG signaling pathway
N00785  Mutation-inactivated PAX8 to TSH-TG signaling pathway
N00793  TSH-DUOX2-TG signaling pathway
N00794  Mutation-inactivated DUOX2 to TSH-DUOX2-TG signaling pathway
N00797  Mutation-activated TSHR to TSH-TG signaling pathway
Disease
H00250  Congenital nongoitrous hypothyroidism (CHNG)
H01269  Congenital hyperthyroidism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    7253 (TSHR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    7253 (TSHR)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    7253 (TSHR)
   04918 Thyroid hormone synthesis
    7253 (TSHR)
 09160 Human Diseases
  09163 Immune disease
   05320 Autoimmune thyroid disease
    7253 (TSHR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    7253 (TSHR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Thyrotropin
    7253 (TSHR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 LRR_8 LRR_5 SSFA2_C
Motif
Other DBs
NCBI-GeneID: 7253
NCBI-ProteinID: NP_000360
OMIM: 603372
HGNC: 12373
Ensembl: ENSG00000165409
Vega: OTTHUMG00000171429
Pharos: P16473(Tclin)
UniProt: P16473 A0A0A0MTJ0
Structure
PDB: 

Position
14q31.1
AA seq 764 aa AA seqDB search
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE
DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ
VQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
NT seq 2295 nt NT seq  +upstreamnt  +downstreamnt
atgaggccggcggacttgctgcagctggtgctgctgctcgacctgcccagggacctgggc
ggaatggggtgttcgtctccaccctgcgagtgccatcaggaggaggacttcagagtcacc
tgcaaggatattcaacgcatccccagcttaccgcccagtacgcagactctgaagcttatt
gagactcacctgagaactattccaagtcatgcattttctaatctgcccaatatttccaga
atctacgtatctatagatgtgactctgcagcagctggaatcacactccttctacaatttg
agtaaagtgactcacatagaaattcggaataccaggaacttaacttacatagaccctgat
gccctcaaagagctccccctcctaaagttccttggcattttcaacactggacttaaaatg
ttccctgacctgaccaaagtttattccactgatatattctttatacttgaaattacagac
aacccttacatgacgtcaatccctgtgaatgcttttcagggactatgcaatgaaaccttg
acactgaagctgtacaacaatggctttacttcagtccaaggatatgctttcaatgggaca
aagctggatgctgtttacctaaacaagaataaatacctgacagttattgacaaagatgca
tttggaggagtatacagtggaccaagcttgctggacgtgtctcaaaccagtgtcactgcc
cttccatccaaaggcctggagcacctgaaggaactgatagcaagaaacacctggactctt
aagaaacttccactttccttgagtttccttcacctcacacgggctgacctttcttaccca
agccactgctgtgcttttaagaatcagaagaaaatcagaggaatccttgagtccttgatg
tgtaatgagagcagtatgcagagcttgcgccagagaaaatctgtgaatgccttgaatagc
cccctccaccaggaatatgaagagaatctgggtgacagcattgttgggtacaaggaaaag
tccaagttccaggatactcataacaacgctcattattacgtcttctttgaagaacaagag
gatgagatcattggttttggccaggagctcaaaaacccccaggaagagactctacaagct
tttgacagccattatgactacaccatatgtggggacagtgaagacatggtgtgtaccccc
aagtccgatgagttcaacccgtgtgaagacataatgggctacaagttcctgagaattgtg
gtgtggttcgttagtctgctggctctcctgggcaatgtctttgtcctgcttattctcctc
accagccactacaaactgaacgtcccccgctttctcatgtgcaacctggcctttgcggat
ttctgcatggggatgtacctgctcctcatcgcctctgtagacctctacactcactctgag
tactacaaccatgccatcgactggcagacaggccctgggtgcaacacggctggtttcttc
actgtctttgcaagcgagttatcggtgtatacgctgacggtcatcaccctggagcgctgg
tatgccatcaccttcgccatgcgcctggaccggaagatccgcctcaggcacgcatgtgcc
atcatggttgggggctgggtttgctgcttccttctcgccctgcttcctttggtgggaata
agtagctatgccaaagtcagtatctgcctgcccatggacaccgagacccctcttgctctg
gcatatattgtttttgttctgacgctcaacatagttgccttcgtcatcgtctgctgctgt
tatgtgaagatctacatcacagtccgaaatccgcagtacaacccaggggacaaagatacc
aaaattgccaagaggatggctgtgttgatcttcaccgacttcatatgcatggccccaatc
tcattctatgctctgtcagcaattctgaacaagcctctcatcactgttagcaactccaaa
atcttgctggtactcttctatccacttaactcctgtgccaatccattcctctatgctatt
ttcaccaaggccttccagagggatgtgttcatcctactcagcaagtttggcatctgtaaa
cgccaggctcaggcataccgggggcagagggttcctccaaagaacagcactgatattcag
gttcaaaaggttacccacgagatgaggcagggtctccacaacatggaagatgtctatgaa
ctgattgaaaactcccatctaaccccaaagaagcaaggccaaatctcagaagagtatatg
caaacggttttgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (7)   
   KEGG NETWORK (7)   
Disease (6)   
   KEGG DISEASE (2)   
   OMIM (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (19)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (47)   
   RefSeq(nuc) (7)   
   GenBank (20)   
   EMBL (20)   
Protein domain (4)   
   Pfam (4)   
All databases (117)   

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