KEGG   Homo sapiens (human): 7296
Entry
7296              CDS       T01001                                 
Symbol
TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR
Name
(RefSeq) thioredoxin reductase 1
  KO
K22182  thioredoxin reductase (NADPH) [EC:1.8.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00450  Selenocompound metabolism
hsa05200  Pathways in cancer
hsa05225  Hepatocellular carcinoma
Network
nt06226  KEAP1-NRF2 signaling
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    7296 (TXNRD1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7296 (TXNRD1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    7296 (TXNRD1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.9  thioredoxin-disulfide reductase
     7296 (TXNRD1)
SSDB
Motif
Pfam: Pyr_redox_2 Pyr_redox_dim Pyr_redox Pyr_redox_3 FAD_binding_2 Glutaredoxin AlaDh_PNT_C FAD_oxidored HI0933_like DAO Thi4 GIDA NAD_binding_8 FAD_binding_3 Lycopene_cycl
Other DBs
NCBI-GeneID: 7296
NCBI-ProteinID: NP_001087240
OMIM: 601112
HGNC: 12437
Ensembl: ENSG00000198431
Pharos: Q16881(Tclin)
UniProt: Q16881
Structure
Position
12:104215779..104350307
AA seq 649 aa
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
NT seq 1950 nt   +upstreamnt  +downstreamnt
atgggctgcgccgagggcaaggcagtggcggcggccgccccaacggagctgcagacgaaa
ggcaagaacggcgatggccgccgtaggtcagctaaagatcatcaccctggtaaaactttg
ccagagaacccagcaggattcaccagcacggccactgcagactccagagccctgcttcag
gcctatatagatggtcactctgtggtcatcttcagtaggtccacatgcacacgctgtact
gaggtaaagaagttatttaaatctctgtgtgttccttattttgtgcttgaacttgatcaa
acagaggacggtcgggccctggaaggaacgctctcggaattggccgcggaaaccgatctg
cccgttgtgtttgtgaaacagagaaagataggcggccatggtccaaccttgaaggcttat
caggagggcagacttcaaaagctactaaaaatgaacggccctgaagatcttcccaagtcc
tatgactatgaccttatcatcattggaggtggctcaggaggtctggcagctgctaaggag
gcagcccaatatggcaagaaggtgatggtcctggactttgtcactcccacccctcttgga
actagatggggtctcggaggaacatgtgtgaatgtgggttgcatacctaaaaaactgatg
catcaagcagctttgttaggacaagccctgcaagactctcgaaattatggatggaaagtc
gaggagacagttaagcatgattgggacagaatgatagaagctgtacagaatcacattggc
tctttgaattggggctaccgagtagctctgcgggagaaaaaagtcgtctatgagaatgct
tatgggcaatttattggtcctcacaggattaaggcaacaaataataaaggcaaagaaaaa
atttattcagcagagagatttctcattgccactggtgaaagaccacgttacttgggcatc
cctggtgacaaagaatactgcatcagcagtgatgatcttttctccttgccttactgcccg
ggtaagaccctggttgttggagcatcctatgtcgctttggagtgcgctggatttcttgct
ggtattggtttagacgtcactgttatggttaggtccattcttcttagaggatttgaccag
gacatggccaacaaaattggtgaacacatggaagaacatggcatcaagtttataagacag
ttcgtaccaattaaagttgaacaaattgaagcagggacaccaggccgactcagagtagta
gctcagtccaccaatagtgaggaaatcattgaaggagaatataatacggtgatgctggca
ataggaagagatgcttgcacaagaaaaattggcttagaaaccgtaggggtgaagataaat
gaaaagactggaaaaatacctgtcacagatgaagaacagaccaatgtgccttacatctat
gccattggcgatatattggaggataaggtggagctcaccccagttgcaatccaggcagga
agattgctggctcagaggctctatgcaggttccactgtcaagtgtgactatgaaaatgtt
ccaaccactgtatttactcctttggaatatggtgcttgtggcctttctgaggagaaagct
gtggagaagtttggggaagaaaatattgaggtttaccatagttacttttggccattggaa
tggacgattccgtcaagagataacaacaaatgttatgcaaaaataatctgtaatactaaa
gacaatgaacgtgttgtgggctttcacgtactgggtccaaatgctggagaagttacacaa
ggctttgcagctgcgctcaaatgtggactgaccaaaaagcagctggacagcacaattgga
atccaccctgtctgtgcagaggtattcacaacattgtctgtgaccaagcgctctggggca
agcatcctccaggctggctgctgaggttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   NAGAHAMA-S (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (119)   
   RefSeq(nuc) (7)   
   GenBank (56)   
   EMBL (56)   
3D Structure (7)   
   PDB (7)   
Protein domain (15)   
   Pfam (15)   
All databases (201)   

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