KEGG   Homo sapiens (human): 7298Help
Entry
7298              CDS       T01001                                 

Gene name
TYMS, HST422, TMS, TS
Definition
(RefSeq) thymidylate synthetase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01523  Antifolate resistance
Drug target
Capecitabine: D01223
Carmofur: D01784
Doxifluridine: D01309
Floxuridine: D04197
Fluorouracil (DG00687): D00584 D07974
Metesind glucuronate: D04964
Pemetrexed (DG00682): D03828 D06503 D07472 D10596 D11352
Plevitrexed: D10803
Raltitrexed: D01064
Tegafur: D01244
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    7298 (TYMS)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    7298 (TYMS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    7298 (TYMS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     7298 (TYMS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Thymidylat_synt
Motif
Other DBs
NCBI-GeneID: 7298
NCBI-ProteinID: NP_001062
OMIM: 188350
HGNC: 12441
Ensembl: ENSG00000176890
Vega: OTTHUMG00000131473
Pharos: P04818(Tclin)
UniProt: P04818 Q53Y97
Structure
PDB: 

Position
18p11.32
AA seq 313 aa AA seqDB search
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
NT seq 942 nt NT seq  +upstreamnt  +downstreamnt
atgcctgtggccggctcggagctgccgcgccggcccttgccccccgccgcacaggagcgg
gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatccaacacatc
ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc
atgcaggcgcgctacagcctgagagatgaattccctctgctgacaaccaaacgtgtgttc
tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag
ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc
ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg
cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccaa
ctgcaaagagtgattgacaccatcaaaaccaaccctgacgacagaagaatcatcatgtgc
gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag
ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc
ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc
acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat
cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcagg
attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg
tacaatccgcatccaactattaaaatggaaatggctgtttag

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