KEGG   Homo sapiens (human): 7298Help
Entry
7298              CDS       T01001                                 

Gene name
TYMS, HST422, TMS, TS
Definition
(RefSeq) thymidylate synthetase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01523  Antifolate resistance
Drug target
Capecitabine: D01223
Carmofur: D01784
Doxifluridine: D01309
Floxuridine: D04197
Fluorouracil (DG00687): D00584 D07974
Metesind glucuronate: D04964
Pemetrexed (DG00682): D03828 D06503 D07472 D10596 D11352
Plevitrexed: D10803
Raltitrexed: D01064
Tegafur: D01244
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    7298 (TYMS)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    7298 (TYMS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    7298 (TYMS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     7298 (TYMS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Thymidylat_synt
Motif
Other DBs
NCBI-GeneID: 7298
NCBI-ProteinID: NP_001062
OMIM: 188350
HGNC: 12441
Ensembl: ENSG00000176890
Vega: OTTHUMG00000131473
Pharos: P04818(Tclin)
UniProt: P04818 Q53Y97
Structure
PDB: 

Position
18p11.32
AA seq 313 aa AA seqDB search
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
NT seq 942 nt NT seq  +upstreamnt  +downstreamnt
atgcctgtggccggctcggagctgccgcgccggcccttgccccccgccgcacaggagcgg
gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatccaacacatc
ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc
atgcaggcgcgctacagcctgagagatgaattccctctgctgacaaccaaacgtgtgttc
tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag
ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc
ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg
cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccaa
ctgcaaagagtgattgacaccatcaaaaccaaccctgacgacagaagaatcatcatgtgc
gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag
ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc
ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc
acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat
cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcagg
attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg
tacaatccgcatccaactattaaaatggaaatggctgtttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Drug (15)   
   KEGG DRUG (15)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (19)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (32)   
   RefSeq(nuc) (4)   
   GenBank (14)   
   EMBL (14)   
Protein domain (1)   
   Pfam (1)   
All databases (97)   

Download RDF
DBGET integrated database retrieval system