KEGG   Homo sapiens (human): 7298
Entry
7298              CDS       T01001                                 
Symbol
TYMS, DKCD, HST422, TMS, TS
Name
(RefSeq) thymidylate synthetase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
hsa01523  Antifolate resistance
hsa04981  Folate transport and metabolism
Module
hsa_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Disease
H00507  Dyskeratosis congenita
Drug target
Arfolitixorin (DG03254): D11447 D12528
Capecitabine: D01223<JP/US>
Carmofur: D01784
Doxifluridine: D01309<JP>
Floxuridine: D04197<US>
Fluorouracil (DG00687): D00584<JP/US> D07974
Fosifloxuridine nafalbenamide: D12388
Metesind glucuronate: D04964
Pemetrexed (DG00682): D03828<US> D06503<JP/US> D07472<US> D10596<JP/US> D11352<US>
Plevitrexed: D10803
Raltitrexed: D01064
Tegafur: D01244
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    7298 (TYMS)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    7298 (TYMS)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    7298 (TYMS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    7298 (TYMS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     7298 (TYMS)
SSDB
Motif
Pfam: Thymidylat_synt
Other DBs
NCBI-GeneID: 7298
NCBI-ProteinID: NP_001062
OMIM: 188350
HGNC: 12441
Ensembl: ENSG00000176890
UniProt: P04818 Q53Y97
Structure
Position
18:657653..673578
AA seq 313 aa
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
NT seq 942 nt   +upstreamnt  +downstreamnt
atgcctgtggccggctcggagctgccgcgccggcccttgccccccgccgcacaggagcgg
gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatccaacacatc
ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc
atgcaggcgcgctacagcctgagagatgaattccctctgctgacaaccaaacgtgtgttc
tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag
ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc
ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg
cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccaa
ctgcaaagagtgattgacaccatcaaaaccaaccctgacgacagaagaatcatcatgtgc
gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag
ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc
ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc
acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat
cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcagg
attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg
tacaatccgcatccaactattaaaatggaaatggctgtttag

  All links  
Disease (2)   
   OMIM (2)   
Gene (25)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (19)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (33)   
   RefSeq(nuc) (5)   
   GenBank (14)   
   EMBL (14)   
3D Structure (61)   
   PDB (61)   
Protein domain (1)   
   Pfam (1)   
All databases (130)   

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