KEGG T01001: 7311

Homo sapiens (human): 7311

Entry

7311 CDS T01001

Gene name

UBA52, CEP52, HUBCEP52, L40, RPL40

Definition

(RefSeq) ubiquitin A-52 residue ribosomal protein fusion product 1

K02927

ubiquitin-large subunit ribosomal protein L40e

Organism

hsa Homo sapiens (human)

Pathway

hsa03010

Ribosome

hsa04120

Ubiquitin mediated proteolysis

hsa04137

Mitophagy - animal

hsa05012

Parkinson disease

hsa05131

Shigellosis

hsa05167

Kaposi sarcoma-associated herpesvirus infection

Network

nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease

Element

N01027

UCHL1-mediated hydrolysis

N01028

Mutation-inactivated UCHL1 to UCHL1-mediated hydrolysis

N01029

26S proteasome-mediated protein degradation

N01144

Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation

N01145

Mutation-inactivated VCP to 26S proteasome-mediated protein degradation

N01146

Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09122 Translation
   03010 Ribosome
    7311 (UBA52)
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    7311 (UBA52)
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    7311 (UBA52)
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    7311 (UBA52)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    7311 (UBA52)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    7311 (UBA52)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03011 Ribosome [BR:hsa03011]
    7311 (UBA52)
   04121 Ubiquitin system [BR:hsa04121]
    7311 (UBA52)
Ribosome [BR:hsa03011]
Ribosomal proteins
  Eukaryotes
   Large subunit
    7311 (UBA52)
  Archaea
    7311 (UBA52)
Ubiquitin system [BR:hsa04121]
Ubiquitins and ubiquitin-like proteins
  Ubiquitins
   7311 (UBA52)

SSDB

Motif

Pfam:

ubiquitin Ribosomal_L40e Rad60-SLD Ubiquitin_2 Rad60-SLD_2 TBK1_ULD Ubiquitin_5 DUF2407

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P62987(Tbio)

UniProt:

P62987 Q3MIH3 Q7Z4P3

Structure

PDB:

5NVG 5GOB 5GOD 4XOF 5W46 3NHE 5NL4 5DK8 1OGW 5V1Y 5KYC 5KYF 4IUM 1XD3 5NLF 4PIH 4PIJ 4UN2 5NLI 5NLJ 4ZPZ 5GOJ 5K9P 5J8P 3BY4 2GBM 5GOI 6FDK 5OXH 2ZCB 2GBN 5KYD 5OXI 5X3N 5EMZ 5AF5 6B7M 5NMC 4I6N 3VUX 3V6C 3PRP 3NS8 6EI1 5GOC 6FGE 6OI4 4K7S 4K7U 4K7W 3N32 6GLC 5ULF 5GO7 3ONS 1UBI 1UBQ 3EHV 5X3M 5TXK 5GOK 3EFU 6B7O 5WFI 5L8H 5AF4 3ALB 6ISU 3MHS 6GZS 5CVM 4WZP 4LDT 3H7P 5D0M 3TMP 5ULH 5GOH 4PIG 3VUW 2JF5 5NL5 3HM3 5KYE 5GOG 3VUY 5JBY 2GBK 2G45 5YDR 5V1Z 5WVO 5LRW 4WLR 4IG7 3PHW 2GBR 1S1Q 4FJV 6JB7 6AQR 5JBV 5DFL 3V6E 4RF1 5X3O 3NOB 6OQ1 5IFR 4XOK 2XEW 3A33 2O6V 2IBI 5GO8 5AIU 5XPK 5VZW 4R62 6PGV 4UEL 3ZNH 3PRM 3H7S 2WDT 1NBF 3C0R 5OHK 4BOS 4DHJ 3UGB 3OFI 6ASR 5XDP 5ULK 3AUL 5EYA 3IFW 1TBE 6IF1 5BNB 6FX4 5OHL 3RUL 3PT2 3OJ3 2GMI 5YDK 3I3T 6A6I 5N38 5TUT 3DVG 2OJR 5CAW 5CRA 5D0K 5N2W 6JB6 4BVU 3PTF 3O65 3MTN 3JSV 3DVN 2HTH 1F9J 4MM3 5L8W 6S53 5OHV 5OHP 5LRV 4RF0 3VFK 3KVF 3K9P 3IHP 3KW5 5LRX 4HXD 5JP3 4JQW 3ZLZ 3TBL 6FYH 4XOL 6NJ9 3PHD 2XK5 3N30 3EEC 4S1Z 4BOZ 6EQI 5YIK 4LCD 4DHZ 6DC6 5O44 4WUR 5YIJ 6KIU 5ZBU 5UDH 4DDG 5JTV 5JTJ 5CVN 5AF6 3OJ4 5VNZ 5EDV 5H7S 6O96 6H4H 5KHY 2AYO 6NQA 5OHN 4JIO 4UF6 4DDI 4ZUX 5CVO 6NOG 5VO0 6KIV 6KIW 6J99 6FTX 5GJQ 5KGF 6JMA 4WHV 5A5B 6KOW 6KOX 6K4I 6OQ2 6N13 5ZD0 5YMY 5VZM 5XK4 5XK5 5VEY 5VF0 5XBO 5UJL 5UJN 2NBD 2NBE 2N3U 2N3V 2N3W 2N2K 2N13 2MWS 2MUR 2MSG 2MRO 2MRE 2MOR 2MJB 2MJ5 2RU6 2MCN 2MBQ 2MBO 2MBH 2MBB 2LZ6 2LVO 2LVP 2LVQ 2RSU 2LJ5 2L3Z 2L0T 2L0F 2RR9 2KWV 2KWU 2KTF 2KOX 2KN5 2KLG 2KJH 2KHW 2KDF 2K8B 2K8C 2K6D 2JZZ 2JY6 2Z59 2JRI 2PE9 2PEA 2NR2 2J7Q 2DEN 1ZGU 1YX5 1YX6 2BGF 1XQQ 1Q5W 1G6J 1FXT 1D3Z

Position

19p13.11

AA seq 128 aa
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNN
LRPKKKVK

NT seq 387 nt +upstreamnt +downstreamnt
atgcagatctttgtgaagaccctcactggcaaaaccatcacccttgaggtcgagcccagt
gacaccattgagaatgtcaaagccaaaattcaagacaaggagggtatcccacctgaccag
cagcgtctgatatttgccggcaaacagctggaggatggccgcactctctcagactacaac
atccagaaagagtccaccctgcacctggtgttgcgcctgcgaggtggcattattgagcct
tctctccgccagcttgcccagaaatacaactgcgacaagatgatctgccgcaagtgctat
gctcgccttcaccctcgtgctgtcaactgccgcaagaagaagtgtggtcacaccaacaac
ctgcgtcccaagaagaaggtcaaataa

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