KEGG   Homo sapiens (human): 7332
Entry
7332              CDS       T01001                                 

Gene name
UBE2L3, E2-F1, L-UBC, UBCH7, UbcM4
Definition
(RefSeq) ubiquitin conjugating enzyme E2 L3
  KO
K04552  ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa05012  Parkinson disease
Network
nt06420  Ubiquitin-proteasome system
nt06463  Parkinson disease
  Element
N01019  Parkin-mediated ubiquitination
N01020  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01021  Parkin-mediated ubiquitination
N01022  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01023  Parkin-mediated ubiquitination
N01024  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01025  Parkin-mediated ubiquitination
N01026  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    7332 (UBE2L3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    7332 (UBE2L3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7332 (UBE2L3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.23  E2 ubiquitin-conjugating enzyme
     7332 (UBE2L3)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-conjugating enzymes (E2)
  Ubiquitin-conjugating enzymes
   7332 (UBE2L3)
SSDB
Motif
Pfam: UQ_con UEV Prok-E2_B RWD
Other DBs
NCBI-GeneID: 7332
NCBI-ProteinID: NP_003338
OMIM: 603721
HGNC: 12488
Ensembl: ENSG00000185651
Vega: OTTHUMG00000150823
Pharos: P68036(Tbio)
UniProt: P68036 A0A024R1A4
Structure
PDB: 

Position
22q11.21
AA seq 154 aa
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
NT seq 465 nt   +upstreamnt  +downstreamnt
atggcggccagcaggaggctgatgaaggagcttgaagaaatccgcaaatgtgggatgaaa
aacttccgtaacatccaggttgatgaagctaatttattgacttggcaagggcttattgtt
cctgacaaccctccatatgataagggagccttcagaatcgaaatcaactttccagcagag
tacccattcaaaccaccgaagatcacatttaaaacaaagatctatcacccaaacatcgac
gaaaaggggcaggtctgtctgccagtaattagtgccgaaaactggaagccagcaaccaaa
accgaccaagtaatccagtccctcatagcactggtgaatgacccccagcctgagcacccg
cttcgggctgacctagctgaagaatactctaaggaccgtaaaaaattctgtaagaatgct
gaagagtttacaaagaaatatggggaaaagcgacctgtggactaa

KEGG   Homo sapiens (human): 9246
Entry
9246              CDS       T01001                                 

Gene name
UBE2L6, RIG-B, UBCH8
Definition
(RefSeq) ubiquitin conjugating enzyme E2 L6
  KO
K04553  ubiquitin-conjugating enzyme E2 L6 [EC:2.3.2.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa05012  Parkinson disease
Network
nt06420  Ubiquitin-proteasome system
nt06463  Parkinson disease
  Element
N01019  Parkin-mediated ubiquitination
N01020  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01021  Parkin-mediated ubiquitination
N01022  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01023  Parkin-mediated ubiquitination
N01024  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01025  Parkin-mediated ubiquitination
N01026  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    9246 (UBE2L6)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    9246 (UBE2L6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9246 (UBE2L6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.23  E2 ubiquitin-conjugating enzyme
     9246 (UBE2L6)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-conjugating enzymes (E2)
  Ubiquitin-conjugating enzymes
   9246 (UBE2L6)
  UBL-conjugating enzymes
   9246 (UBE2L6)
SSDB
Motif
Pfam: UQ_con RWD UEV Prok-E2_B
Other DBs
NCBI-GeneID: 9246
NCBI-ProteinID: NP_004214
OMIM: 603890
HGNC: 12490
Ensembl: ENSG00000156587
Vega: OTTHUMG00000167047
Pharos: O14933(Tbio)
UniProt: O14933
Structure
PDB: 
1WZV 1WZW 2KJH

Position
11q12.1
AA seq 153 aa
MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE
YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP
LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS
NT seq 462 nt   +upstreamnt  +downstreamnt
atgatggcgagcatgcgagtggtgaaggagctggaggatcttcagaagaagcctccccca
tacctgcggaacctgtccagcgatgatgccaatgtcctggtgtggcacgctctcctccta
cccgaccaacctccctaccacctgaaagccttcaacctgcgcatcagcttcccgccggag
tatccgttcaagcctcccatgatcaaattcacaaccaagatctaccaccccaacgtggac
gagaacggacagatttgcctgcccatcatcagcagtgagaactggaagccttgcaccaag
acttgccaagtcctggaggccctcaatgtgctggtgaatagaccgaatatcagggagccc
ctgcggatggacctcgctgacctgctgacacagaatccggagctgttcagaaagaatgcc
gaagagttcaccctccgattcggagtggaccggccctcctaa

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