KEGG   Homo sapiens (human): 7345Help
Entry
7345              CDS       T01001                                 

Gene name
UCHL1, HEL-117, HEL-S-53, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, SPG79, Uch-L1
Definition
(RefSeq) ubiquitin C-terminal hydrolase L1
  KO
K05611  ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease (PD)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05012 Parkinson disease
    7345 (UCHL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases [BR:hsa01002]
    7345 (UCHL1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7345 (UCHL1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     7345 (UCHL1)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C12: ubiquitin C-terminal hydrolase family
   7345 (UCHL1)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UCH
    7345 (UCHL1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_C12
Motif
Other DBs
NCBI-GeneID: 7345
NCBI-ProteinID: NP_004172
OMIM: 191342
HGNC: 12513
Ensembl: ENSG00000154277
Vega: OTTHUMG00000099377
Pharos: P09936(Tchem)
UniProt: P09936 V9HW74
Structure
PDB: 

Position
4p13
AA seq 223 aa AA seqDB search
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
NT seq 672 nt NT seq  +upstreamnt  +downstreamnt
atgcagctcaagccgatggagatcaaccccgagatgctgaacaaagtgctgtcccggctg
ggggtcgccggccagtggcgcttcgtggacgtgctggggctggaagaggagtctctgggc
tcggtgccagcgcctgcctgcgcgctgctgctgctgtttcccctcacggcccagcatgag
aacttcaggaaaaagcagattgaagagctgaagggacaagaagttagtcctaaagtgtac
ttcatgaagcagaccattgggaattcctgtggcacaatcggacttattcacgcagtggcc
aataatcaagacaaactgggatttgaggatggatcagttctgaaacagtttctttctgaa
acagagaaaatgtcccctgaagacagagcaaaatgctttgaaaagaatgaggccatacag
gcagcccatgatgccgtggcacaggaaggccaatgtcgggtagatgacaaggtgaatttc
cattttattctgtttaacaacgtggatggccacctctatgaacttgatggacgaatgcct
tttccggtgaaccatggcgccagttcagaggacaccctgctgaaggacgctgccaaggtc
tgcagagaattcaccgagcgtgagcaaggagaagtccgcttctctgccgtggctctctgc
aaggcagcctaa

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