KEGG T01001: 7416

Homo sapiens (human): 7416

Entry

7416              CDS       T01001

Symbol

VDAC1, PORIN, VDAC-1

Name

(RefSeq) voltage dependent anion channel 1

K05862

voltage-dependent anion channel protein 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04217

Necroptosis

hsa04218

Cellular senescence

hsa04613

Neutrophil extracellular trap formation

hsa04621

NOD-like receptor signaling pathway

hsa04979

Cholesterol metabolism

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05017

Spinocerebellar ataxia

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05131

Shigellosis

hsa05164

Influenza A

hsa05166

Human T-cell leukemia virus 1 infection

hsa05208

Chemical carcinogenesis - reactive oxygen species

hsa05415

Diabetic cardiomyopathy

Network

nt06131  Apoptosis (viruses and bacteria)
nt06170  Influenza A virus (IAV)
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease

Element

N00745

IAV PB1-F2 to intrinsic apoptotic pathway

N00950

Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways

N00957

Mutation-caused abberant ATXN2/3 to mGluR5-Ca2+ -apoptotic pathway

N00967

VGCC-Ca2+ -apoptotic pathway

N00984

mGluR5-Ca2+ -apoptotic pathway

N00985

Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway

N00987

Mutation-caused aberrant Htt to transport of calcium

N01000

mAChR-Ca2+ -apoptotic pathway

N01001

Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway

N01002

Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway

N01003

Mutation-caused aberrant Abeta to transport of calcium

N01004

Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway

N01006

Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway

N01007

Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway

N01008

Mutation-caused aberrant PSEN1 to mGluR5-Ca2+ -apoptotic pathway

N01031

Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway

N01151

Mutation-inactivated SIGMAR1 to Ca2+ -apoptotic pathway

N01199

Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway

N01200

Scrapie conformation PrPSc to transport of calcium

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    7416 (VDAC1)
   04022 cGMP-PKG signaling pathway
    7416 (VDAC1)
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    7416 (VDAC1)
   04218 Cellular senescence
    7416 (VDAC1)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    7416 (VDAC1)
   04621 NOD-like receptor signaling pathway
    7416 (VDAC1)
  09154 Digestive system
   04979 Cholesterol metabolism
    7416 (VDAC1)
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    7416 (VDAC1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7416 (VDAC1)
   05164 Influenza A
    7416 (VDAC1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    7416 (VDAC1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7416 (VDAC1)
   05012 Parkinson disease
    7416 (VDAC1)
   05014 Amyotrophic lateral sclerosis
    7416 (VDAC1)
   05016 Huntington disease
    7416 (VDAC1)
   05017 Spinocerebellar ataxia
    7416 (VDAC1)
   05020 Prion disease
    7416 (VDAC1)
   05022 Pathways of neurodegeneration - multiple diseases
    7416 (VDAC1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    7416 (VDAC1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    7416 (VDAC1)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    7416 (VDAC1)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial protein import machinery
  Outer membrane
   Porin
    7416 (VDAC1)
Ion channels [BR:hsa04040]
Chloride channels
  Maxi chloride channel (VDAC)
   7416 (VDAC1)

SSDB

Motif

Pfam:

Porin_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P21796(Tbio)

UniProt:

P21796 A0A1L1UHR1 B3KTS5

Structure

Position

5:complement(133971871..134114540)

AA seq 283 aa
MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLET
KYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKR
EHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQL
HTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNS
SLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA

NT seq 852 nt +upstreamnt +downstreamnt
atggctgtgccacccacgtatgccgatcttggcaaatctgccagggatgtcttcaccaag
ggctatggatttggcttaataaagcttgatttgaaaacaaaatctgagaatggattggaa
tttacaagctcaggctcagccaacactgagaccaccaaagtgacgggcagtctggaaacc
aagtacagatggactgagtacggcctgacgtttacagagaaatggaataccgacaataca
ctaggcaccgagattactgtggaagatcagcttgcacgtggactgaagctgaccttcgat
tcatccttctcacctaacactgggaaaaaaaatgctaaaatcaagacagggtacaagcgg
gagcacattaacctgggctgcgacatggatttcgacattgctgggccttccatccggggt
gctctggtgctaggttacgagggctggctggccggctaccagatgaattttgagactgca
aaatcccgagtgacccagagcaactttgcagttggctacaagactgatgaattccagctt
cacactaatgtgaatgacgggacagagtttggcggctccatttaccagaaagtgaacaag
aagttggagaccgctgtcaatcttgcctggacagcaggaaacagtaacacgcgcttcgga
atagcagccaagtatcagattgaccctgacgcctgcttctcggctaaagtgaacaactcc
agcctgataggtttaggatacactcagactctaaagccaggtattaaactgacactgtca
gctcttctggatggcaagaacgtcaatgctggtggccacaagcttggtctaggactggaa
tttcaagcataa

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