KEGG   Homo sapiens (human): 7490
Entry
7490              CDS       T01001                                 
Symbol
WT1, AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33
Name
(RefSeq) WT1 transcription factor
  KO
K09234  Wilms tumor protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
  Element
N00137  EWSR1-WT1 fusion to transcriptional activation
Disease
H00607  46,XY gonadal dysgenesis
H01657  Nephrotic syndrome
H01985  Desmoplastic small round cell tumor
H02301  Nephroblastoma
Drug target
Adegramotide acetate: D11058
Adegrapepimut-S: D11057
Elatipepimut-S: D11059
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    7490 (WT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7490 (WT1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 SP/KLF family and related proteins
    7490 (WT1)
SSDB
Motif
Pfam: WT1 zf-H2C2_2 zf-C2H2 zf-C2H2_4 FOXP-CC zf-met Zap1_zf1 zf-C2H2_15 DUF7565
Other DBs
NCBI-GeneID: 7490
NCBI-ProteinID: NP_000369
OMIM: 607102
HGNC: 12796
Ensembl: ENSG00000184937
UniProt: P19544 Q6PI38
Structure
Position
11:complement(32387775..32435539)
AA seq 502 aa
MDFLLLQDPASTCVPEPASQHTLRSGPGCLQQPEQQGVRDPGGIWAKLGAAEASAERLQG
RRSRGASGSEPQQMGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASA
YGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGAC
RYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHH
AAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLY
QMTSQLECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVP
GVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF
SRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFAR
SDELVRHHNMHQRNMTKLQLAL
NT seq 1509 nt   +upstreamnt  +downstreamnt
ctggacttcctcttgctgcaggacccggcttccacgtgtgtcccggagccggcgtctcag
cacacgctccgctccgggcctgggtgcctacagcagccagagcagcagggagtccgggac
ccgggcggcatctgggccaagttaggcgccgccgaggccagcgctgaacgtctccagggc
cggaggagccgcggggcgtccgggtctgagccgcagcaaatgggctccgacgtgcgggac
ctgaacgcgctgctgcccgccgtcccctccctgggtggcggcggcggctgtgccctgcct
gtgagcggcgcggcgcagtgggcgccggtgctggactttgcgcccccgggcgcttcggct
tacgggtcgttgggcggccccgcgccgccaccggctccgccgccacccccgccgccgccg
cctcactccttcatcaaacaggagccgagctggggcggcgcggagccgcacgaggagcag
tgcctgagcgccttcactgtccacttttccggccagttcactggcacagccggagcctgt
cgctacgggcccttcggtcctcctccgcccagccaggcgtcatccggccaggccaggatg
tttcctaacgcgccctacctgcccagctgcctcgagagccagcccgctattcgcaatcag
ggttacagcacggtcaccttcgacgggacgcccagctacggtcacacgccctcgcaccat
gcggcgcagttccccaaccactcattcaagcatgaggatcccatgggccagcagggctcg
ctgggtgagcagcagtactcggtgccgcccccggtctatggctgccacacccccaccgac
agctgcaccggcagccaggctttgctgctgaggacgccctacagcagtgacaatttatac
caaatgacatcccagcttgaatgcatgacctggaatcagatgaacttaggagccacctta
aagggccacagcacagggtacgagagcgataaccacacaacgcccatcctctgcggagcc
caatacagaatacacacgcacggtgtcttcagaggcattcaggatgtgcgacgtgtgcct
ggagtagccccgactcttgtacggtcggcatctgagaccagtgagaaacgccccttcatg
tgtgcttacccaggctgcaataagagatattttaagctgtcccacttacagatgcacagc
aggaagcacactggtgagaaaccataccagtgtgacttcaaggactgtgaacgaaggttt
tctcgttcagaccagctcaaaagacaccaaaggagacatacaggtgtgaaaccattccag
tgtaaaacttgtcagcgaaagttctcccggtccgaccacctgaagacccacaccaggact
catacaggtgaaaagcccttcagctgtcggtggccaagttgtcagaaaaagtttgcccgg
tcagatgaattagtccgccatcacaacatgcatcagagaaacatgaccaaactccagctg
gcgctttga

  All links  
Disease (9)   
   OMIM (9)   
Gene (47)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PRONIT (26)   
Protein sequence (21)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (18)   
DNA sequence (42)   
   RefSeq(nuc) (20)   
   GenBank (11)   
   EMBL (11)   
3D Structure (27)   
   PDB (27)   
Protein domain (9)   
   Pfam (9)   
All databases (155)   

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