KEGG   Homo sapiens (human): 760
Entry
760               CDS       T01001                                 
Symbol
CA2, CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282
Name
(RefSeq) carbonic anhydrase 2
  KO
K18245  carbonic anhydrase 2 [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
hsa04964  Proximal tubule bicarbonate reclamation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
Disease
H00241  Combined proximal and distal renal tubular acidosis (RTA type 3)
H00436  Osteopetrosis
H02310  Renal tubular acidosis
Drug target
Acetazolamide (DG01134): D00218<JP/US> D01196<JP/US>
Brinzolamide: D00652<JP/US>
Clofenamide: D01822
Diclofenamide: D00518<US>
Dorzolamide (DG01135): D00653<JP/US> D07871
Ethoxzolamide: D02441
Methazolamide: D00655<US>
Sezolamide hydrochloride: D03845
Topiramate: D00537<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    760 (CA2)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    760 (CA2)
   04972 Pancreatic secretion
    760 (CA2)
   04976 Bile secretion
    760 (CA2)
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    760 (CA2)
   04966 Collecting duct acid secretion
    760 (CA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    760 (CA2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     760 (CA2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   760 (CA2)
SSDB
Motif
Pfam: Carb_anhydrase
Other DBs
NCBI-GeneID: 760
NCBI-ProteinID: NP_000058
OMIM: 611492
HGNC: 1373
Ensembl: ENSG00000104267
UniProt: P00918 V9HW21
Structure
Position
8:85464007..85481493
AA seq 260 aa
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
NT seq 783 nt   +upstreamnt  +downstreamnt
atgtcccatcactgggggtacggcaaacacaacggacctgagcactggcataaggacttc
cccattgccaagggagagcgccagtcccctgttgacatcgacactcatacagccaagtat
gacccttccctgaagcccctgtctgtttcctatgatcaagcaacttccctgaggatcctc
aacaatggtcatgctttcaacgtggagtttgatgactctcaggacaaagcagtgctcaag
ggaggacccctggatggcacttacagattgattcagtttcactttcactggggttcactt
gatggacaaggttcagagcatactgtggataaaaagaaatatgctgcagaacttcacttg
gttcactggaacaccaaatatggggattttgggaaagctgtgcagcaacctgatggactg
gccgttctaggtatttttttgaaggttggcagcgctaaaccgggccttcagaaagttgtt
gatgtgctggattccattaaaacaaagggcaagagtgctgacttcactaacttcgatcct
cgtggcctccttcctgaatccttggattactggacctacccaggctcactgaccacccct
cctcttctggaatgtgtgacctggattgtgctcaaggaacccatcagcgtcagcagcgag
caggtgttgaaattccgtaaacttaacttcaatggggagggtgaacccgaagaactgatg
gtggacaactggcgcccagctcagccactgaagaacaggcaaatcaaagcttccttcaaa
taa

  All links  
Disease (2)   
   OMIM (2)   
Gene (118)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   NAGAHAMA-S (1)   
   OC (1)   
   PROTHERM (107)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
3D Structure (1135)   
   PDB (1135)   
Protein domain (1)   
   Pfam (1)   
All databases (1293)   

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