KEGG   Homo sapiens (human): 771
Entry
771               CDS       T01001                                 
Symbol
CA12, CA-XII, CAXII, HsT18816, T18816
Name
(RefSeq) carbonic anhydrase 12
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Disease
H01302  Hyperchlorhidrosis isolated (HCHLH)
Drug target
Acetazolamide (DG01134): D00218<JP/US> D01196<JP/US>
Clofenamide: D01822
Diclofenamide: D00518<US>
Dorzolamide (DG01135): D00653<JP/US> D07871
Ethoxzolamide: D02441
Methazolamide: D00655<US>
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    771 (CA12)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     771 (CA12)
SSDB
Motif
Pfam: Carb_anhydrase DUF4191 DUF3149 Wzy_C
Other DBs
NCBI-GeneID: 771
NCBI-ProteinID: NP_001209
OMIM: 603263
HGNC: 1371
Ensembl: ENSG00000074410
UniProt: O43570
Structure
Position
15:complement(63321378..63381846)
AA seq 354 aa
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
NT seq 1065 nt   +upstreamnt  +downstreamnt
atgccccggcgcagcctgcacgcggcggccgtgctcctgctggtgatcttaaaggaacag
ccttccagcccggccccagtgaacggttccaagtggacttattttggtcctgatggggag
aatagctggtccaagaagtacccgtcgtgtgggggcctgctgcagtcccccatagacctg
cacagtgacatcctccagtatgacgccagcctcacgcccctcgagttccaaggctacaat
ctgtctgccaacaagcagtttctcctgaccaacaatggccattcagtgaagctgaacctg
ccctcggacatgcacatccagggcctccagtctcgctacagtgccacgcagctgcacctg
cactgggggaacccgaatgacccgcacggctctgagcacaccgtcagcggacagcacttc
gccgccgagctgcacattgtccattataactcagacctttatcctgacgccagcactgcc
agcaacaagtcagaaggcctcgctgtcctggctgttctcattgagatgggctccttcaat
ccgtcctatgacaagatcttcagtcaccttcaacatgtaaagtacaaaggccaggaagca
ttcgtcccgggattcaacattgaagagctgcttccggagaggaccgctgaatattaccgc
taccgggggtccctgaccacacccccttgcaaccccactgtgctctggacagttttccga
aaccccgtgcaaatttcccaggagcagctgctggctttggagacagccctgtactgcaca
cacatggacgacccttcccccagagaaatgatcaacaacttccggcaggtccagaagttc
gatgagaggctggtatacacctccttctcccaagtgcaagtctgtactgcggcaggactg
agtctgggcatcatcctctcactggccctggctggcattcttggcatctgtattgtggtg
gtggtgtccatttggcttttcagaaggaagagtatcaaaaaaggtgataacaagggagtc
atttacaagccagccaccaagatggagactgaggcccacgcttga

  All links  
Disease (2)   
   OMIM (2)   
Gene (21)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (42)   
   RefSeq(nuc) (4)   
   GenBank (19)   
   EMBL (19)   
3D Structure (31)   
   PDB (31)   
Protein domain (4)   
   Pfam (4)   
All databases (105)   

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