KEGG   Homo sapiens (human): 7879
Entry
7879              CDS       T01001                                 
Symbol
RAB7A, CMT2B, PRO2706, RAB7
Name
(RefSeq) RAB7A, member RAS oncogene family
  KO
K07897  Ras-related protein Rab-7A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04144  Endocytosis
hsa04145  Phagosome
hsa04148  Efferocytosis
hsa05132  Salmonella infection
hsa05146  Amoebiasis
hsa05152  Tuberculosis
Network
nt06181  Salmonella
nt06532  Autophagy
nt06536  Mitophagy
  Element
N01295  Rab7-regulated microtubule minus-end directed transport
N01296  Salmonella SopD2 to Rab7-regulated microtubule minus-end directed transport
N01300  Tethering of late endosomes and lysosomes
N01301  Salmonella SifA to Tethering of late endosomes and lysosomes
N01721  Autophagosome and lysosome fusion, tethering factor
N01760  Endosomal Rab cycles
Disease
H00264  Charcot-Marie-Tooth disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    7879 (RAB7A)
   04145 Phagosome
    7879 (RAB7A)
   04142 Lysosome
    7879 (RAB7A)
   04140 Autophagy - animal
    7879 (RAB7A)
   04137 Mitophagy - animal
    7879 (RAB7A)
   04148 Efferocytosis
    7879 (RAB7A)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    7879 (RAB7A)
   05152 Tuberculosis
    7879 (RAB7A)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7879 (RAB7A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7879 (RAB7A)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7879 (RAB7A)
   04031 GTP-binding proteins [BR:hsa04031]
    7879 (RAB7A)
Membrane trafficking [BR:hsa04131]
 Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab GTPases
    7879 (RAB7A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   7879 (RAB7A)
  Exosomal proteins of other body fluids (saliva and urine)
   7879 (RAB7A)
  Exosomal proteins of colorectal cancer cells
   7879 (RAB7A)
  Exosomal proteins of bladder cancer cells
   7879 (RAB7A)
GTP-binding proteins [BR:hsa04031]
 Small (monomeric) G-proteins
  Rab Family
   Rab7/9 [OT]
    7879 (RAB7A)
SSDB
Motif
Pfam: Ras Roc Arf MMR_HSR1 GTP_EFTU RsgA_GTPase Gtr1_RagA ATP_bind_1 cobW nSTAND3 PduV-EutP Septin AAA_7 NTPase_1 AAA_22 AAA_16 G-alpha AAA_5 AAA_24 ATPase_2 NB-ARC AAA_14 NACHT SRPRB ATP-synt_ab ABC_tran
Other DBs
NCBI-GeneID: 7879
NCBI-ProteinID: NP_004628
OMIM: 602298
HGNC: 9788
Ensembl: ENSG00000075785
UniProt: P51149 A0A158RFU6
Structure
Position
3:128726183..128814798
AA seq 207 aa
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQ
IWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPF
VVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEV
ELYNEFPEPIKLDKNDRAKASAESCSC
NT seq 624 nt   +upstreamnt  +downstreamnt
atgacctctaggaagaaagtgttgctgaaggttatcatcctgggagattctggagtcggg
aagacatcactcatgaaccagtatgtgaataagaaattcagcaatcagtacaaagccaca
ataggagctgactttctgaccaaggaggtgatggtggatgacaggctagtcacaatgcag
atatgggacacagcaggacaggaacggttccagtctctcggtgtggccttctacagaggt
gcagactgctgcgttctggtatttgatgtgactgcccccaacacattcaaaaccctagat
agctggagagatgagtttctcatccaggccagtccccgagatcctgaaaacttcccattt
gttgtgttgggaaacaagattgacctcgaaaacagacaagtggccacaaagcgggcacag
gcctggtgctacagcaaaaacaacattccctactttgagaccagtgccaaggaggccatc
aacgtggagcaggcgttccagacgattgcacggaatgcacttaagcaggaaacggaggtg
gagctgtacaacgaatttcctgaacctatcaaactggacaagaatgaccgggccaaggcc
tcggcagaaagctgcagttgctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (41)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (14)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (35)   
   RefSeq(nuc) (1)   
   GenBank (17)   
   EMBL (17)   
3D Structure (9)   
   PDB (9)   
Protein domain (26)   
   Pfam (26)   
All databases (117)   

Download RDF
DBGET integrated database retrieval system