KEGG   Homo sapiens (human): 79068
Entry
79068             CDS       T01001                                 

Gene name
FTO, ALKBH9, BMIQ14, GDFD
Definition
(RefSeq) FTO alpha-ketoglutarate dependent dioxygenase
  KO
K19469  mRNA N6-methyladenine demethylase [EC:1.14.11.53]
Organism
hsa  Homo sapiens (human)
Disease
H00409  Type 2 diabetes mellitus
H00926  Growth retardation, developmental delay, coarse facies, and early death
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    79068 (FTO)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.53  mRNA N6-methyladenine demethylase
     79068 (FTO)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Negative regulators of mRNA 3' end processing
     79068 (FTO)
SSDB
Motif
Pfam: FTO_NTD FTO_CTD
Other DBs
NCBI-GeneID: 79068
NCBI-ProteinID: NP_001073901
OMIM: 610966
HGNC: 24678
Ensembl: ENSG00000140718
Vega: OTTHUMG00000158780
Pharos: Q9C0B1(Tbio)
UniProt: Q9C0B1 B3KU60 Q99770
Structure
PDB: 

Position
16q12.2
AA seq 505 aa
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
NT seq 1518 nt   +upstreamnt  +downstreamnt
atgaagcgcaccccgactgccgaggaacgagagcgcgaagctaagaaactgaggcttctt
gaagagcttgaagacacttggctcccttatctgacccccaaagatgatgaattctatcag
cagtggcagctgaaatatcctaaactaattctccgagaagccagcagtgtatctgaggag
ctccataaagaggttcaagaagcctttctcacactgcacaagcatggctgcttatttcgg
gacctggttaggatccaaggcaaagatctgctcactccggtatctcgcatcctcattggt
aatccaggctgcacctacaagtacctgaacaccaggctctttacggtcccctggccagtg
aaagggtctaatataaaacacaccgaggctgaaatagccgctgcttgtgagaccttcctc
aagctcaatgactacctgcagatagaaaccatccaggctttggaagaacttgctgccaaa
gagaaggctaatgaggatgctgtgccattgtgtatgtctgcagatttccccagggttggg
atgggttcatcctacaacggacaagatgaagtggacattaagagcagagcagcatacaac
gtaactttgctgaatttcatggatcctcagaaaatgccatacctgaaagaggaaccttat
tttggcatggggaaaatggcagtgagctggcatcatgatgaaaatctggtggacaggtca
gcggtggcagtgtacagttatagctgtgaaggccctgaagaggaaagtgaggatgactct
catctcgaaggcagggatcctgatatttggcatgttggttttaagatctcatgggacata
gagacacctggtttggcgataccccttcaccaaggagactgctatttcatgcttgatgat
ctcaatgccacccaccaacactgtgttttggccggttcacaacctcggtttagttccacc
caccgagtggcagagtgctcaacaggaaccttggattatattttacaacgctgtcagttg
gctctgcagaatgtctgtgacgatgtggacaatgatgatgtctctttgaaatcctttgag
cctgcagttttgaaacaaggagaagaaattcataatgaggtcgagtttgagtggctgagg
cagttttggtttcaaggcaatcgatacagaaagtgcactgactggtggtgtcaacccatg
gctcaactggaagcactgtggaagaagatggagggtgtgacaaatgctgtgcttcatgaa
gttaaaagagaggggctccccgtggaacaaaggaatgaaatcttgactgccatccttgcc
tcgctcactgcacgccagaacctgaggagagaatggcatgccaggtgccagtcacgaatt
gcccgaacattacctgctgatcagaagccagaatgtcggccatactgggaaaaggatgat
gcttcgatgcctctgccgtttgacctcacagacatcgtttcagaactcagaggtcagctt
ctggaagcaaaaccctag

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Ontology (3)   
   KEGG BRITE (3)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (25)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (21)   
DNA sequence (43)   
   RefSeq(nuc) (23)   
   GenBank (10)   
   EMBL (10)   
Protein domain (2)   
   Pfam (2)   
All databases (108)   

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