KEGG   Homo sapiens (human): 7941
Entry
7941              CDS       T01001                                 
Symbol
PLA2G7, LDL-PLA2, LP-PLA2, PAFAD, PAFAH
Name
(RefSeq) phospholipase A2 group VII
  KO
K01062  platelet-activating factor acetylhydrolase [EC:3.1.1.47]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00565  Ether lipid metabolism
hsa01100  Metabolic pathways
Disease
H00079  Asthma
Drug target
Darapladib: D03650
Goxalapladib: D04368
Rilapladib: D05728
Varespladib (DG01394): D06283 D08107 D08221
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00565 Ether lipid metabolism
    7941 (PLA2G7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.47  1-alkyl-2-acetylglycerophosphocholine esterase
     7941 (PLA2G7)
SSDB
Motif
Pfam: PAF-AH_p_II Abhydrolase_1 PETase Hydrolase_4 Chlorophyllase Peptidase_S9 Abhydrolase_6 Abhydrolase_2 Abhydrolase_5 Abhydrolase_3 PAE DUF676 Lipase_3 DLH
Other DBs
NCBI-GeneID: 7941
NCBI-ProteinID: NP_001161829
OMIM: 601690
HGNC: 9040
Ensembl: ENSG00000146070
UniProt: Q13093
Structure
Position
6:complement(46704201..46735721)
AA seq 441 aa
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
NT seq 1326 nt   +upstreamnt  +downstreamnt
atggtgccacccaaattgcatgtgcttttctgcctctgcggctgcctggctgtggtttat
ccttttgactggcaatacataaatcctgttgcccatatgaaatcatcagcatgggtcaac
aaaatacaagtactgatggctgctgcaagctttggccaaactaaaatcccccggggaaat
gggccttattccgttggttgtacagacttaatgtttgatcacactaataagggcaccttc
ttgcgtttatattatccatcccaagataatgatcgccttgacaccctttggatcccaaat
aaagaatatttttggggtcttagcaaatttcttggaacacactggcttatgggcaacatt
ttgaggttactctttggttcaatgacaactcctgcaaactggaattcccctctgaggcct
ggtgaaaaatatccacttgttgttttttctcatggtcttggggcattcaggacactttat
tctgctattggcattgacctggcatctcatgggtttatagttgctgctgtagaacacaga
gatagatctgcatctgcaacttactatttcaaggaccaatctgctgcagaaataggggac
aagtcttggctctaccttagaaccctgaaacaagaggaggagacacatatacgaaatgag
caggtacggcaaagagcaaaagaatgttcccaagctctcagtctgattcttgacattgat
catggaaagccagtgaagaatgcattagatttaaagtttgatatggaacaactgaaggac
tctattgatagggaaaaaatagcagtaattggacattcttttggtggagcaacggttatt
cagactcttagtgaagatcagagattcagatgtggtattgccctggatgcatggatgttt
ccactgggtgatgaagtatattccagaattcctcagcccctcttttttatcaactctgaa
tatttccaatatcctgctaatatcataaaaatgaaaaaatgctactcacctgataaagaa
agaaagatgattacaatcaggggttcagtccaccagaattttgctgacttcacttttgca
actggcaaaataattggacacatgctcaaattaaagggagacatagattcaaatgtagct
attgatcttagcaacaaagcttcattagcattcttacaaaagcatttaggacttcataaa
gattttgatcagtgggactgcttgattgaaggagatgatgagaatcttattccagggacc
aacattaacacaaccaatcaacacatcatgttacagaactcttcaggaatagagaaatac
aattag

  All links  
Disease (2)   
   OMIM (2)   
Gene (22)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (33)   
   RefSeq(nuc) (7)   
   GenBank (13)   
   EMBL (13)   
3D Structure (33)   
   PDB (33)   
Protein domain (14)   
   Pfam (14)   
All databases (113)   

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