KEGG   Homo sapiens (human): 7941
Entry
7941              CDS       T01001                                 
Symbol
PLA2G7, LDL-PLA2, LP-PLA2, PAFAD, PAFAH
Name
(RefSeq) phospholipase A2 group VII
  KO
K01062  platelet-activating factor acetylhydrolase [EC:3.1.1.47]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00565  Ether lipid metabolism
hsa01100  Metabolic pathways
Disease
H00079  Asthma
Drug target
Darapladib: D03650
Goxalapladib: D04368
Rilapladib: D05728
Varespladib (DG01394): D06283 D08107 D08221
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00565 Ether lipid metabolism
    7941 (PLA2G7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.47  1-alkyl-2-acetylglycerophosphocholine esterase
     7941 (PLA2G7)
SSDB
Motif
Pfam: PAF-AH_p_II Chlorophyllase2 Hydrolase_4 Abhydrolase_1 Peptidase_S9 Chlorophyllase Abhydrolase_6 Abhydrolase_2 Abhydrolase_5 DLH PGAP1 Abhydrolase_3 DUF676 Lipase_3
Other DBs
NCBI-GeneID: 7941
NCBI-ProteinID: NP_001161829
OMIM: 601690
HGNC: 9040
Ensembl: ENSG00000146070
Pharos: Q13093(Tchem)
UniProt: Q13093
Structure
Position
6:complement(46704201..46735721)
AA seq 441 aa
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
NT seq 1326 nt   +upstreamnt  +downstreamnt
atggtgccacccaaattgcatgtgcttttctgcctctgcggctgcctggctgtggtttat
ccttttgactggcaatacataaatcctgttgcccatatgaaatcatcagcatgggtcaac
aaaatacaagtactgatggctgctgcaagctttggccaaactaaaatcccccggggaaat
gggccttattccgttggttgtacagacttaatgtttgatcacactaataagggcaccttc
ttgcgtttatattatccatcccaagataatgatcgccttgacaccctttggatcccaaat
aaagaatatttttggggtcttagcaaatttcttggaacacactggcttatgggcaacatt
ttgaggttactctttggttcaatgacaactcctgcaaactggaattcccctctgaggcct
ggtgaaaaatatccacttgttgttttttctcatggtcttggggcattcaggacactttat
tctgctattggcattgacctggcatctcatgggtttatagttgctgctgtagaacacaga
gatagatctgcatctgcaacttactatttcaaggaccaatctgctgcagaaataggggac
aagtcttggctctaccttagaaccctgaaacaagaggaggagacacatatacgaaatgag
caggtacggcaaagagcaaaagaatgttcccaagctctcagtctgattcttgacattgat
catggaaagccagtgaagaatgcattagatttaaagtttgatatggaacaactgaaggac
tctattgatagggaaaaaatagcagtaattggacattcttttggtggagcaacggttatt
cagactcttagtgaagatcagagattcagatgtggtattgccctggatgcatggatgttt
ccactgggtgatgaagtatattccagaattcctcagcccctcttttttatcaactctgaa
tatttccaatatcctgctaatatcataaaaatgaaaaaatgctactcacctgataaagaa
agaaagatgattacaatcaggggttcagtccaccagaattttgctgacttcacttttgca
actggcaaaataattggacacatgctcaaattaaagggagacatagattcaaatgtagct
attgatcttagcaacaaagcttcattagcattcttacaaaagcatttaggacttcataaa
gattttgatcagtgggactgcttgattgaaggagatgatgagaatcttattccagggacc
aacattaacacaaccaatcaacacatcatgttacagaactcttcaggaatagagaaatac
aattag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (5)   
   KEGG DISEASE (1)   
   OMIM (4)   
Drug (6)   
   KEGG DRUG (6)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
   PHAROS (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (23)   
   RefSeq(nuc) (7)   
   GenBank (8)   
   EMBL (8)   
3D Structure (33)   
   PDB (33)   
Protein domain (14)   
   Pfam (14)   
All databases (125)   

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