KEGG   Homo sapiens (human): 7994
Entry
7994              CDS       T01001                                 
Symbol
KAT6A, ARTHS, MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220
Name
(RefSeq) lysine acetyltransferase 6A
  KO
K11305  histone acetyltransferase MYST3 [EC:2.3.1.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
Disease
H00773  Autosomal dominant intellectual developmental disorder
Drug target
Prifetrastat: D12983
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    7994 (KAT6A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7994 (KAT6A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7994 (KAT6A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.48  histone acetyltransferase
     7994 (KAT6A)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2HisCys zinc factors
    7994 (KAT6A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    7994 (KAT6A)
   HAT complexes
    MOZ/MORF complex
     7994 (KAT6A)
SSDB
Motif
Pfam: MOZ_SAS SAMD1_WH zf-MYST PHD Linker_histone PHD_4 zf-C2H2_ZNF462_1st PHD_2 Acetyltransf_7 PHD-1st_NSD Acetyltransf_1 HTH_Mga
Other DBs
NCBI-GeneID: 7994
NCBI-ProteinID: NP_006757
OMIM: 601408
HGNC: 13013
Ensembl: ENSG00000083168
UniProt: Q92794 A5PKX7
Structure
Position
8:complement(41929479..42051987)
AA seq 2004 aa
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI
LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS
IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS
CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM
PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS
PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK
DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF
LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR
FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI
VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP
VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC
RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR
RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP
DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR
KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS
PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED
DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH
DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE
GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP
NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT
ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ
QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ
QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG
AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL
AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK
SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN
AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG
PSHHSYMNAAGVPKQSLNGPYMRR
NT seq 6015 nt   +upstreamnt  +downstreamnt
atggtaaaactcgcaaacccgctttatactgagtggattttggaggccatcaaaaaagtg
aaaaagcagaaacagcgtccttcagaagaaaggatatgcaatgctgtgtcttcatcccat
ggcttggatcgtaaaactgttttagaacaattggagttgagtgttaaagatggaacaatt
ttaaaagtctcaaataaaggactcaattcctataaagatcctgataatcctgggcgaata
gcacttcctaagcctcggaaccatggaaaattggataataaacaaaatgtggattggaat
aaactgataaagcgggcagttgagggcttggcagagtctggtggctcaactttgaaaagc
attgaacgttttttgaaaggtcagaaggatgtgtctgcattattcggaggcagtgctgcc
tctggctttcaccagcagttacgattggctatcaaacgtgccattggccacggcagactc
cttaaagatggacctctttatcggctcaacactaaagcaaccaacgtggatgggaaagag
agttgtgagtctctttcctgtttacctccagtgtcccttcttccacatgaaaaggataag
ccggttgctgaaccaatccccatctgtagtttctgtcttggtacaaaagaacaaaaccga
gaaaagaagccagaggaactcatctcctgtgccgactgtggcaacagtggccatccatcc
tgtttaaagttttcccctgaactaacggttcgagtgaaggccttacggtggcagtgcatc
gagtgtaaaacatgcagctcctgtcgagatcaaggcaaaaatgcggataacatgctcttt
tgtgattcatgtgaccgaggttttcacatggagtgttgtgatccgccactcacccgtatg
ccaaaaggcatgtggatatgtcaaatatgtcgacctaggaaaaaaggacgaaaacttcta
caaaagaaggcagcacagataaaacggcgctatactaatccaataggacgtccaaaaaac
aggttaaagaaacaaaacacggtatcaaaaggtcccttcagcaaagttcgaactggccct
ggaaggggtaggaaacgaaaaatcactctttccagccaatcagcatcatcatcatcagaa
gaaggatatttagagcggatagatggcttggacttctgcagagatagcaatgtctccttg
aagttcaacaagaaaaccaaagggctcattgatggccttaccaaattttttaccccttcc
cctgatgggcggaaagctcggggggaagtggtggactactctgagcaatatcgaatcaga
aagaggggcaacaggaaatcaagcacttcagattggcccacagacaatcaggatggctgg
gatggcaaacaagaaaatgaggagcgactttttgggagccaggaaatcatgactgagaaa
gatatggaattatttcgtgatatccaagaacaagcactgcagaaagttggagtgactggt
ccccctgatccacaagtccgctgtccctctgtcattgagtttgggaagtatgaaattcac
acctggtactcctccccatatcctcaagaatactcaaggctgcccaaattgtatctttgt
gaattttgtctaaaatatatgaaaagtagaactattctgcagcagcacatgaagaaatgt
ggttggttccatcctcctgccaatgagatttacagaaagaataatatttctgtctttgag
gttgatgggaatgtgagtaccatttattgtcaaaacctgtgtcttttggcaaagttgttt
cttgaccacaaaaccctctattacgatgtggagccatttcttttttatgtactaacacag
aatgatgtcaagggctgccaccttgttggctacttttctaaggaaaagcactgccaacag
aagtacaatgtttcctgtataatgattcttcctcaataccagcgtaagggctatggcagg
tttctcatcgatttcagttatttgttatcaaagcgtgaaggccaagcagggtctccagag
aaaccgttatctgatctgggtcgtctttcctacatggcatattggaaaagtgtaatattg
gagtgcctttatcaccaaaatgacaagcagatcagcattaagaagttaagcaagttgact
ggaatctgccctcaagacatcacttccacactccaccacctacgaatgctggacttccgt
agtgaccaatttgtgattatccgccgggaaaaacttatccaggatcacatggcaaagctt
cagctgaatttgcgacctgtagatgtagatccagaatgtttgcgctggactccagtcata
gtgtccaactctgtggtctcagaggaggaagaagaggaggctgaggaaggagaaaacgaa
gagccacagtgccaggaaagagaattagagatcagtgtgggaaagtctgtgtctcatgag
aacaaagaacaagattcttattcagtagaaagtgaaaagaaaccagaagttatggctcca
gtcagttctacacgtttgagcaaacaagtccttcctcatgatagtcttcctgcaaatagc
cagccatctcggaggggccgctgggggaggaagaacagaaaaacccaggaacgttttggt
gataaagattctaaactgctcttggaagagacgtcttcagctcctcaggaacaatatgga
gaatgtggggagaaatcagaagccacccaggaacaatacactgaaagtgaagaacagctg
gtggcttctgaggagcagccaagccaggacgggaaacctgaccttcccaagagaagactc
agtgagggggttgagccctggcgaggacagctcaagaaaagccctgaggctctgaagtgc
agattaacagaaggaagtgagaggctgccccgtcgctacagtgagggtgacagggctgtc
ctcaggggcttcagtgagagcagcgaggaggaggaggagccggaaagccctcggtcaagc
tcgccaccaattctcacaaagcccacgctgaagcgaaagaaaccatttctccaccgaagg
aggagagtccgaaagcgcaaacaccacaatagcagtgtagtcacagaaactatttctgag
accactgaagtgttagatgaaccttttgaagattctgactccgagaggccaatgccaaga
ttagaacccacgtttgagatcgatgaagaagaggaggaagaggatgaaaatgaacttttc
cctagagaatacttccgtcgtttgtcttcgcaggatgtactcaggtgtcagtcctcttct
aagaggaagtctaaagatgaagaagaagatgaagagtcagatgatgctgatgacactcct
atcttaaagccagtatctcttttgcgaaaacgtgatgtgaagaattctcctcttgagcca
gatacatccacacctttgaaaaagaaaaagggatggcccaaaggcaagagccgcaaacca
atccactggaagaaaagacctggtcgaaaaccaggatttaagttgagtcgggaaatcatg
ccagtttctactcaagcatgcgtcattgagcccatcgtttccattcctaaagctggacgt
aaacccaagatccaggagagtgaagaaactgttgagccaaaagaagacatgcccctaccc
gaggagaggaaggaggaggaggagatgcaagcagaggcagaagaggctgaagagggtgag
gaagaggatgcagccagcagtgaagtcccagcagcctctccagcagacagcagcaatagt
cctgagaccgaaaccaaggagcctgaggtggaggaggaagaagagaagccccgtgtctca
gaggagcagaggcagtcagaggaggagcagcaggaattagaggagccagagccagaggag
gaggaagatgcagctgcagagactgcccagaatgacgaccacgacgctgatgatgaggat
gatggccacctggagtccacaaagaaaaaggagctagaggaacagcccacgagggaagat
gtcaaggaggagcctggtgttcaagagtcttttttagatgctaatatgcagaagagtagg
gaaaagataaaggataaagaggaaaccgagctggattccgaagaggagcagccttcccat
gacacgtccgtggtgtcagagcagatggctgggtctgaggacgaccacgaagaagactcc
cacactaaggaagagttaatcgaattaaaagaggaggaagagattcctcatagtgagctg
gatctggaaactgtacaggcagtgcagtctttgactcaagaagaaagcagtgagcatgag
ggcgcctaccaggactgtgaggaaactcttgcggcgtgtcagaccctgcagagttacacc
caggctgacgaggaccctcagatgtccatggttgaagactgtcatgcgtcagaacataat
agccctatctcctccgttcagtctcaccccagccagtcagtccgttcggtcagcagtccc
aacgtgcctgcccttgagagtggctacacccagatcagcccagaacaaggatccctgtcc
gcaccctctatgcagaacatggagaccagccccatgatggatgtgccttccgtatcagac
cactctcagcaggtggtggacagcggcttcagtgacctgggcagcattgagagcaccact
gaaaactatgagaacccaagcagttacgactccacgatgggcggcagcatctgtgggaac
agctcttcccagagcagctgctcctacggtgggctgtcgtcctccagcagcctcacccag
agcagctgtgtggtcactcagcagatggccagcatgggcagcagctgcagcatgatgcag
cagagcagcgtccagcctgctgccaactgcagcatcaagtcacctcagagctgcgtggtg
gagaggcctcccagtaaccagcagcagcagccgccaccaccgcctccacagcagccacag
ccgccgccgccacaaccacaaccagcaccacagcctccaccaccccagcagcagccgcaa
cagcagccgcagcctcagccccagcagcctccacccccaccccctccccagcagcagccc
ccgctgtcacagtgtagtatgaataacagtttcaccccagctcctatgatcatggagata
ccagaatctggaagcactgggaacataagtatctatgagaggattccaggggattttggt
gccggcagctactctcaaccatcagccaccttcagcctagccaagctgcagcagctgacc
aacaccattatggaccctcatgccatgccttatagccattctcctgctgtgacttcctat
gcaaccagtgtttctctgtccaatacaggactggctcagctggctccatctcatccctta
gctgggactcctcaagcacaagccaccatgacgccacccccaaacttggcatccactacc
atgaacctcacatctcctctgcttcagtgcaacatgtctgccaccaacattggcattcct
cacacgcagagattgcaagggcaaatgccagtgaaggggcacatttccatccgctccaag
tctgcgccactgccctctgcggctgctcaccagcagcagctgtatggccgtagcccatcg
gcagttgccatgcaggctggccctcgcgcactggctgttcagcgtggcatgaacatgggg
gttaatctgatgcctactcccgcctataatgtcaattccatgaatatgaacaccttgaat
gccatgaacagctatcgaatgacacagcccatgatgaacagcagttaccatagtaaccct
gcctacatgaaccagacagcacagtatcctatgcagatgcagatgggaatgatggggagc
caggcctatacccagcagcctatgcagcctaaccctcatgggaacatgatgtacacaggc
ccctcccatcacagctacatgaacgctgctggcgtgcccaagcagtcactcaacggacct
tacatgagaagatga

  All links  
Disease (2)   
   OMIM (2)   
Gene (44)   
   RefGene (32)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (36)   
   RefSeq(nuc) (4)   
   GenBank (16)   
   EMBL (16)   
3D Structure (20)   
   PDB (20)   
Protein domain (12)   
   Pfam (12)   
All databases (119)   

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