KEGG   Homo sapiens (human): 80228Help
Entry
80228             CDS       T01001                                 

Gene name
ORAI2, C7orf19, CBCIP2, MEM142B, TMEM142B
Definition
(RefSeq) ORAI calcium release-activated calcium modulator 2
  KO
K16057  calcium release-activated calcium channel protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    80228 (ORAI2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    80228 (ORAI2)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   80228 (ORAI2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Orai-1 DUF2207 DUF4199
Motif
Other DBs
NCBI-GeneID: 80228
NCBI-ProteinID: NP_001119812
OMIM: 610929
HGNC: 21667
Ensembl: ENSG00000160991
Vega: OTTHUMG00000157722
Pharos: Q96SN7(Tbio)
UniProt: Q96SN7
Position
7q22.1
AA seq 254 aa AA seqDB search
MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKL
KASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILP
NVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARR
QPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKL
KVQLDGHERSLQVL
NT seq 765 nt NT seq  +upstreamnt  +downstreamnt
atgagtgctgagcttaacgtgcctatcgacccctctgctcctgcctgccctgagcccggc
cataagggcatggattaccgggactgggtccgccgcagctacctggaactggtcacctct
aaccaccactcggtacaggccctgtcgtggcggaagctctacctgagcagggccaagctg
aaggcctccagcaggacctccgccctcctctccggctttgccatggtggccatggtggag
gtgcagctggagacgcagtaccagtacccgcggccgctgctgattgccttcagcgcctgc
accacggtgctggtggccgtgcacctgttcgccctcctcatcagcacctgcatcctgccc
aatgtggaggccgtgagcaacatccacaacctgaactccatcagcgagtccccgcatgag
cgcatgcacccctacatcgagctggcctggggcttctccaccgtgcttggcatcctactc
ttcctggccgaggtggtgctgctctgctggatcaagttcctccccgtggatgcccggcgc
cagcctggccccccacctggccctgggagtcacacgggctggcaggccgccctggtgtcc
accatcatcatggtgcccgtgggcctcatcttcgtggtcttcaccatccacttctaccgc
tccctggtgcgccacaaaacggagcgccacaaccgcgagatcgaggagctccacaagctc
aaggtccagctggacgggcatgagcgcagcctgcaggtcttgtga

KEGG   Homo sapiens (human): 84876Help
Entry
84876             CDS       T01001                                 

Gene name
ORAI1, CRACM1, IMD9, ORAT1, TAM2, TMEM142A
Definition
(RefSeq) ORAI calcium release-activated calcium modulator 1
  KO
K16056  calcium release-activated calcium channel protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04611  Platelet activation
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
H02258  Tubular aggregate myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    84876 (ORAI1)
   04024 cAMP signaling pathway
    84876 (ORAI1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    84876 (ORAI1)
  09152 Endocrine system
   04924 Renin secretion
    84876 (ORAI1)
   04925 Aldosterone synthesis and secretion
    84876 (ORAI1)
   04927 Cortisol synthesis and secretion
    84876 (ORAI1)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    84876 (ORAI1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    84876 (ORAI1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    84876 (ORAI1)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   84876 (ORAI1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Orai-1 m04gp34like
Motif
Other DBs
NCBI-GeneID: 84876
NCBI-ProteinID: NP_116179
OMIM: 610277
HGNC: 25896
Pharos: Q96D31(Tchem)
UniProt: Q96D31 A0A024RBT3
Structure
PDB: 

Position
12q24.31
AA seq 301 aa AA seqDB search
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
NT seq 906 nt NT seq  +upstreamnt  +downstreamnt
atgcatccggagcccgccccgcccccgagccgcagcagtcccgagcttcccccaagcggc
ggcagcaccaccagcggcagccgccggagccgccgccgcagcggggacggggagcccccg
ggggccccgccaccgccgccgtccgccgtcacctacccggactggatcggccagagttac
tccgaggtgatgagcctcaacgagcactccatgcaggcgctgtcctggcgcaagctctac
ttgagccgcgccaagcttaaagcctccagccggacctcggctctgctctccggcttcgcc
atggtggcaatggtggaggtgcagctggacgctgaccacgactacccaccggggctgctc
atcgccttcagtgcctgcaccacagtgctggtggctgtgcacctgtttgcgctcatgatc
agcacctgcatcctgcccaacatcgaggcggtgagcaacgtgcacaatctcaactcggtc
aaggagtccccccatgagcgcatgcaccgccacatcgagctggcctgggccttctccacc
gtcatcggcacgctgctcttcctagctgaggtggtgctgctctgctgggtcaagttcttg
cccctcaagaagcagccaggccagccaaggcccaccagcaagccccccgccagtggcgca
gcagccaacgtcagcaccagcggcatcaccccgggccaggcagctgccatcgcctcgacc
accatcatggtgcccttcggcctgatctttatcgtcttcgccgtccacttctaccgctca
ctggttagccataagactgaccgacagttccaggagctcaacgagctggcggagtttgcc
cgcttacaggaccagctggaccacagaggggaccaccccctgacgcccggcagccactat
gcctag

KEGG   Homo sapiens (human): 93129Help
Entry
93129             CDS       T01001                                 

Gene name
ORAI3, TMEM142C
Definition
(RefSeq) ORAI calcium release-activated calcium modulator 3
  KO
K16058  calcium release-activated calcium channel protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    93129 (ORAI3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    93129 (ORAI3)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   93129 (ORAI3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Orai-1 KASH
Motif
Other DBs
NCBI-GeneID: 93129
NCBI-ProteinID: NP_689501
OMIM: 610930
HGNC: 28185
Ensembl: ENSG00000175938
Vega: OTTHUMG00000176768
Pharos: Q9BRQ5(Tbio)
UniProt: Q9BRQ5 A0A024QZA7
Position
16p11.2
AA seq 295 aa AA seqDB search
MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAK
LKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLL
PHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAP
LDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGP
GWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV
NT seq 888 nt NT seq  +upstreamnt  +downstreamnt
atgaagggcggcgagggggacgcgggcgagcaggccccgctgaaccctgagggcgagagc
cctgcaggctcggccacgtaccgggagttcgtgcaccgcggctacctggacctcatgggg
gccagtcagcactcgctgcgggcgctcagctggcgccgcctctacctcagccgggccaag
ctcaaagcttccagccgcacgtctgccttgctctcgggcttcgccatggtggccatggtg
gaggtgcagctggagagtgaccacgagtacccaccaggcctgctggtggccttcagtgcc
tgcaccaccgtgctggtggctgtgcacctctttgcactcatggtctccacgtgtctgctg
ccccacattgaagctgtgagcaacatccacaacctcaactctgtccaccagtcgccacac
cagagactgcaccgctacgtggagctggcctggggcttctccactgccctgggcaccttt
ctcttccttgctgaagttgtcctggttggttgggtcaagtttgtgcccattggggctccc
ttggacacaccgacccccatggtgcccacatcccgggtgcccgggactctggcaccagtg
gctacctcccttagtccagcttccaatctcccacggtcctctgcgtctgcagcaccgtcc
caagctgagccagcctgcccaccccggcaagcctgtggtggtggtggggcccatgggcca
ggctggcaagcagccatggcctccacagccatcatggtacccgtggggctcgtgtttgtg
gcctttgccctgcatttctaccgctccttggtggcacacaagacagaccgctacaagcag
gaactagaggaactgaatcgcctgcagggggagctgcaggctgtgtga

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