KEGG   Homo sapiens (human): 80381
Entry
80381             CDS       T01001                                 
Symbol
CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Name
(RefSeq) CD276 molecule
  KO
K06746  immune costimulatory protein B7-H3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
Drug target
Enoblituzumab: D11752
Ifinatamab: D13070
Ifinatamab deruxtecan: D12753
Mirzotamab: D12154
Omburtamab: D11515
Vobramitamab: D12517
Voramitamab duocarmazine: D12518
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    80381 (CD276)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    80381 (CD276)
CD molecules [BR:hsa04090]
 Proteins
  80381 (CD276)
SSDB
Motif
Pfam: Ig_3 ig C2-set_3 Ig_2 V-set I-set C2-set_2 C1-set
Other DBs
NCBI-GeneID: 80381
NCBI-ProteinID: NP_001019907
OMIM: 605715
HGNC: 19137
Ensembl: ENSG00000103855
UniProt: Q5ZPR3
Position
15:73683944..73714514
AA seq 534 aa
MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
AQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSF
TCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQD
GQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQ
RSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEG
RDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPY
SKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLF
DVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIAL
LVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
NT seq 1605 nt   +upstreamnt  +downstreamnt
atgctgcgtcggcggggcagccctggcatgggtgtgcatgtgggtgcagccctgggagca
ctgtggttctgcctcacaggagccctggaggtccaggtccctgaagacccagtggtggca
ctggtgggcaccgatgccaccctgtgctgctccttctcccctgagcctggcttcagcctg
gcacagctcaacctcatctggcagctgacagataccaaacagctggtgcacagctttgct
gagggccaggaccagggcagcgcctatgccaaccgcacggccctcttcccggacctgctg
gcacagggcaacgcatccctgaggctgcagcgcgtgcgtgtggcggacgagggcagcttc
acctgcttcgtgagcatccgggatttcggcagcgctgccgtcagcctgcaggtggccgct
ccctactcgaagcccagcatgaccctggagcccaacaaggacctgcggccaggggacacg
gtgaccatcacgtgctccagctaccagggctaccctgaggctgaggtgttctggcaggat
gggcagggtgtgcccctgactggcaacgtgaccacgtcgcagatggccaacgagcagggc
ttgtttgatgtgcacagcatcctgcgggtggtgctgggtgcaaatggcacctacagctgc
ctggtgcgcaaccccgtgctgcagcaggatgcgcacagctctgtcaccatcacaccccag
agaagccccacaggagccgtggaggtccaggtccctgaggacccggtggtggccctagtg
ggcaccgatgccaccctgcgctgctccttctcccccgagcctggcttcagcctggcacag
ctcaacctcatctggcagctgacagacaccaaacagctggtgcacagtttcaccgaaggc
cgggaccagggcagcgcctatgccaaccgcacggccctcttcccggacctgctggcacaa
ggcaatgcatccctgaggctgcagcgcgtgcgtgtggcggacgagggcagcttcacctgc
ttcgtgagcatccgggatttcggcagcgctgccgtcagcctgcaggtggccgctccctac
tcgaagcccagcatgaccctggagcccaacaaggacctgcggccaggggacacggtgacc
atcacgtgctccagctaccggggctaccctgaggctgaggtgttctggcaggatgggcag
ggtgtgcccctgactggcaacgtgaccacgtcgcagatggccaacgagcagggcttgttt
gatgtgcacagcgtcctgcgggtggtgctgggtgcgaatggcacctacagctgcctggtg
cgcaaccccgtgctgcagcaggatgcgcacggctctgtcaccatcacagggcagcctatg
acattccccccagaggccctgtgggtgaccgtggggctgtctgtctgtctcattgcactg
ctggtggccctggctttcgtgtgctggagaaagatcaaacagagctgtgaggaggagaat
gcaggagctgaggaccaggatggggagggagaaggctccaagacagccctgcagcctctg
aaacactctgacagcaaagaagatgatggacaagaaatagcctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (26)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (20)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (50)   
   RefSeq(nuc) (14)   
   GenBank (18)   
   EMBL (18)   
Protein domain (8)   
   Pfam (8)   
All databases (101)   

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