KEGG   Homo sapiens (human): 815Help
Entry
815               CDS       T01001                                 

Gene name
CAMK2A, CAMKA, CaMKIINalpha, MRD53, MRT63
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II alpha
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
nt06220  Calcium signaling
nt06273  Glioma
nt06316  Angiotensin-aldosterone signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
Disease
H00773  Autosomal dominant mental retardation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    815 (CAMK2A)
   04310 Wnt signaling pathway
    815 (CAMK2A)
   04066 HIF-1 signaling pathway
    815 (CAMK2A)
   04020 Calcium signaling pathway
    815 (CAMK2A)
   04024 cAMP signaling pathway
    815 (CAMK2A)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    815 (CAMK2A)
   04217 Necroptosis
    815 (CAMK2A)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    815 (CAMK2A)
   04922 Glucagon signaling pathway
    815 (CAMK2A)
   04912 GnRH signaling pathway
    815 (CAMK2A)
   04921 Oxytocin signaling pathway
    815 (CAMK2A)
   04916 Melanogenesis
    815 (CAMK2A)
   04925 Aldosterone synthesis and secretion
    815 (CAMK2A)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    815 (CAMK2A)
  09154 Digestive system
   04971 Gastric acid secretion
    815 (CAMK2A)
  09156 Nervous system
   04725 Cholinergic synapse
    815 (CAMK2A)
   04728 Dopaminergic synapse
    815 (CAMK2A)
   04720 Long-term potentiation
    815 (CAMK2A)
   04722 Neurotrophin signaling pathway
    815 (CAMK2A)
  09157 Sensory system
   04740 Olfactory transduction
    815 (CAMK2A)
   04750 Inflammatory mediator regulation of TRP channels
    815 (CAMK2A)
  09158 Development and regeneration
   04360 Axon guidance
    815 (CAMK2A)
  09159 Environmental adaptation
   04713 Circadian entrainment
    815 (CAMK2A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    815 (CAMK2A)
   05205 Proteoglycans in cancer
    815 (CAMK2A)
  09162 Cancer: specific types
   05214 Glioma
    815 (CAMK2A)
  09165 Substance dependence
   05031 Amphetamine addiction
    815 (CAMK2A)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    815 (CAMK2A)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    815 (CAMK2A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    815 (CAMK2A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     815 (CAMK2A)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   815 (CAMK2A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr SnoaL_3 DUF4440 APH Pkinase_fungal Kdo SnoaL_2 SnoaL_4
Motif
Other DBs
NCBI-GeneID: 815
NCBI-ProteinID: NP_741960
OMIM: 114078
HGNC: 1460
Ensembl: ENSG00000070808
Vega: OTTHUMG00000134281
Pharos: Q9UQM7(Tchem)
UniProt: Q9UQM7 A8K161 Q7LDD5 Q8IWE0
Structure
PDB: 

Position
5q32
AA seq 478 aa AA seqDB search
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
NT seq 1437 nt NT seq  +upstreamnt  +downstreamnt
atggccaccatcacctgcacccgcttcacggaagagtaccagctcttcgaggaattgggc
aagggagccttctcggtggtgcgaaggtgtgtgaaggtgctggctggccaggagtatgct
gccaagatcatcaacacaaagaagctgtcagccagagaccatcagaagctggagcgtgaa
gcccgcatctgccgcctgctgaagcaccccaacatcgtccgactacatgacagcatctca
gaggagggacaccactacctgatcttcgacctggtcactggtggggaactgtttgaagat
atcgtggcccgggagtattacagtgaggcggatgccagtcactgtatccagcagatcctg
gaggctgtgctgcactgccaccagatgggggtggtgcaccgggacctgaagcctgagaat
ctgttgctggcctccaagctcaagggtgccgcagtgaagctggcagactttggcctggcc
atagaggtggagggggagcagcaggcatggtttgggtttgcagggactcctggatatctc
tccccagaagtgctgcggaaggacccgtacgggaagcctgtggacctgtgggcttgtggg
gtcatcctgtacatcctgctggttgggtaccccccgttctgggatgaggaccagcaccgc
ctgtaccagcagatcaaagccggcgcctatgatttcccatcgccggaatgggacactgtc
accccggaagccaaggatctgatcaataagatgctgaccattaacccatccaaacgcatc
acagctgccgaagcccttaagcacccctggatctcgcaccgctccaccgtggcatcctgc
atgcacagacaggagaccgtggactgcctgaagaagttcaatgccaggaggaaactgaag
ggagccattctcaccacgatgctggccaccaggaacttctccggagggaagagtggggga
aacaagaagagcgatggtgtgaaggaatcctcagagagcaccaacaccaccatcgaggat
gaagacaccaaagtgcggaaacaggaaattataaaagtgacagagcagctgattgaagcc
ataagcaatggagattttgagtcctacacgaagatgtgcgaccctggcatgacagccttc
gaacctgaggccctggggaacctggttgagggcctggacttccatcgattctattttgaa
aacctgtggtcccggaacagcaagcccgtgcacaccaccatcctgaatccccacatccac
ctgatgggcgacgagtcagcctgcatcgcctacatccgcatcacgcagtacctggacgct
ggcggcatcccacgcaccgcccagtcggaggagacccgtgtctggcaccgccgggatggc
aaatggcagatcgtccacttccacagatctggggcgccctccgtcctgccccactga

KEGG   Homo sapiens (human): 816Help
Entry
816               CDS       T01001                                 

Gene name
CAMK2B, CAM2, CAMK2, CAMKB, MRD54
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II beta
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
nt06220  Calcium signaling
nt06273  Glioma
nt06316  Angiotensin-aldosterone signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
Disease
H00773  Autosomal dominant mental retardation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    816 (CAMK2B)
   04310 Wnt signaling pathway
    816 (CAMK2B)
   04066 HIF-1 signaling pathway
    816 (CAMK2B)
   04020 Calcium signaling pathway
    816 (CAMK2B)
   04024 cAMP signaling pathway
    816 (CAMK2B)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    816 (CAMK2B)
   04217 Necroptosis
    816 (CAMK2B)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    816 (CAMK2B)
   04922 Glucagon signaling pathway
    816 (CAMK2B)
   04912 GnRH signaling pathway
    816 (CAMK2B)
   04921 Oxytocin signaling pathway
    816 (CAMK2B)
   04916 Melanogenesis
    816 (CAMK2B)
   04925 Aldosterone synthesis and secretion
    816 (CAMK2B)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    816 (CAMK2B)
  09154 Digestive system
   04971 Gastric acid secretion
    816 (CAMK2B)
  09156 Nervous system
   04725 Cholinergic synapse
    816 (CAMK2B)
   04728 Dopaminergic synapse
    816 (CAMK2B)
   04720 Long-term potentiation
    816 (CAMK2B)
   04722 Neurotrophin signaling pathway
    816 (CAMK2B)
  09157 Sensory system
   04740 Olfactory transduction
    816 (CAMK2B)
   04750 Inflammatory mediator regulation of TRP channels
    816 (CAMK2B)
  09158 Development and regeneration
   04360 Axon guidance
    816 (CAMK2B)
  09159 Environmental adaptation
   04713 Circadian entrainment
    816 (CAMK2B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    816 (CAMK2B)
   05205 Proteoglycans in cancer
    816 (CAMK2B)
  09162 Cancer: specific types
   05214 Glioma
    816 (CAMK2B)
  09165 Substance dependence
   05031 Amphetamine addiction
    816 (CAMK2B)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    816 (CAMK2B)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    816 (CAMK2B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    816 (CAMK2B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     816 (CAMK2B)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   816 (CAMK2B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr DUF4440 SnoaL_3 SnoaL_2 Pkinase_fungal Kdo SnoaL_4
Motif
Other DBs
NCBI-GeneID: 816
NCBI-ProteinID: NP_001211
OMIM: 607707
HGNC: 1461
Ensembl: ENSG00000058404
Vega: OTTHUMG00000023491
Pharos: Q13554(Tchem)
UniProt: Q13554 A4D2J9
Structure
PDB: 

Position
7p13
AA seq 666 aa AA seqDB search
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKL
KGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTK
NSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVR
RGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSP
ALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIK
TTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHT
TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGA
PVAPLQ
NT seq 2001 nt NT seq  +upstreamnt  +downstreamnt
atggccaccacggtgacctgcacccgcttcaccgacgagtaccagctctacgaggatatt
ggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtat
gcagccaagatcatcaacaccaagaagctgtcagccagagatcaccagaagctggagaga
gaggctcggatctgccgccttctgaagcattccaacatcgtgcgtctccacgacagcatc
tccgaggagggcttccactacctggtcttcgatctggtcactggtggggagctctttgaa
gacattgtggcgagagagtactacagcgaggctgatgccagtcactgtatccagcagatc
ctggaggccgttctccattgtcaccaaatgggggtcgtccacagagacctcaagccggag
aacctgcttctggccagcaagtgcaaaggggctgcagtgaagctggcagacttcggccta
gctatcgaggtgcagggggaccagcaggcatggtttggtttcgctggcacaccaggctac
ctgtcccctgaggtccttcgcaaagaggcgtatggcaagcctgtggacatctgggcatgt
ggggtgatcctgtacatcctgctcgtgggctacccacccttctgggacgaggaccagcac
aagctgtaccagcagatcaaggctggtgcctatgacttcccgtcccctgagtgggacacc
gtcactcctgaagccaaaaacctcatcaaccagatgctgaccatcaaccctgccaagcgc
atcacagcccatgaggccctgaagcacccgtgggtctgccaacgctccacggtagcatcc
atgatgcacagacaggagactgtggagtgtctgaaaaagttcaatgccaggagaaagctc
aagggagccatcctcaccaccatgctggccacacggaatttctcagtgggcagacagacc
accgctccggccacaatgtccaccgcggcctccggcaccaccatggggctggtggaacaa
gccaagagtttactcaacaagaaagcagatggagtcaagccccagacgaatagcaccaaa
aacagtgcagccgccaccagccccaaagggacgcttcctcctgccgccctggagcctcaa
accaccgtcatccataacccagtggacgggattaaggagtcttctgacagtgccaatacc
accatagaggatgaagacgctaaagcccccagggtccccgacatcctgagctcagtgagg
aggggctcgggagccccagaagccgaggggcccctgccctgcccatctccggctcccttt
agccccctgccagccccatcccccaggatctctgacatcctgaactctgtgagaaggggt
tcaggaaccccagaagccgagggccccctctcagcggggcccccgccctgcctgtctccg
gctctcctaggccccctgtcctccccgtcccccaggatctctgacatcctgaactctgtg
aggaggggctcagggaccccagaagccgagggcccctcgccagtggggcccccgccctgc
ccatctccgactatccctggccccctgcccaccccatcccggaagcaggagatcattaag
accacggagcagctcatcgaggccgtcaacaacggtgactttgaggcctacgcgaaaatc
tgtgacccagggctgacctcgtttgagcctgaagcactgggcaacctggttgaagggatg
gacttccacagattctacttcgagaacctgctggccaagaacagcaagccgatccacacg
accatcctgaacccacacgtgcacgtcattggagaggatgccgcctgcatcgcttacatc
cggctcacgcagtacattgacgggcagggccggccccgcaccagccagtctgaggagacc
cgcgtgtggcaccgccgcgacggcaagtggcagaacgtgcacttccactgctcgggcgcg
cctgtggccccgctgcagtga

KEGG   Homo sapiens (human): 817Help
Entry
817               CDS       T01001                                 

Gene name
CAMK2D, CAMKD
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II delta
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
nt06220  Calcium signaling
nt06273  Glioma
nt06316  Angiotensin-aldosterone signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    817 (CAMK2D)
   04310 Wnt signaling pathway
    817 (CAMK2D)
   04066 HIF-1 signaling pathway
    817 (CAMK2D)
   04020 Calcium signaling pathway
    817 (CAMK2D)
   04024 cAMP signaling pathway
    817 (CAMK2D)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    817 (CAMK2D)
   04217 Necroptosis
    817 (CAMK2D)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    817 (CAMK2D)
   04922 Glucagon signaling pathway
    817 (CAMK2D)
   04912 GnRH signaling pathway
    817 (CAMK2D)
   04921 Oxytocin signaling pathway
    817 (CAMK2D)
   04916 Melanogenesis
    817 (CAMK2D)
   04925 Aldosterone synthesis and secretion
    817 (CAMK2D)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    817 (CAMK2D)
  09154 Digestive system
   04971 Gastric acid secretion
    817 (CAMK2D)
  09156 Nervous system
   04725 Cholinergic synapse
    817 (CAMK2D)
   04728 Dopaminergic synapse
    817 (CAMK2D)
   04720 Long-term potentiation
    817 (CAMK2D)
   04722 Neurotrophin signaling pathway
    817 (CAMK2D)
  09157 Sensory system
   04740 Olfactory transduction
    817 (CAMK2D)
   04750 Inflammatory mediator regulation of TRP channels
    817 (CAMK2D)
  09158 Development and regeneration
   04360 Axon guidance
    817 (CAMK2D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    817 (CAMK2D)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    817 (CAMK2D)
   05205 Proteoglycans in cancer
    817 (CAMK2D)
  09162 Cancer: specific types
   05214 Glioma
    817 (CAMK2D)
  09165 Substance dependence
   05031 Amphetamine addiction
    817 (CAMK2D)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    817 (CAMK2D)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    817 (CAMK2D)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    817 (CAMK2D)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     817 (CAMK2D)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   817 (CAMK2D)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr DUF4440 SnoaL_3 Pkinase_fungal Kdo SnoaL_4 SnoaL_2
Motif
Other DBs
NCBI-GeneID: 817
NCBI-ProteinID: NP_001212
OMIM: 607708
HGNC: 1462
Ensembl: ENSG00000145349
Vega: OTTHUMG00000132910
Pharos: Q13557(Tchem)
UniProt: Q13557 A0A024RDK3
Structure
PDB: 

Position
4q26
AA seq 499 aa AA seqDB search
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
NT seq 1500 nt NT seq  +upstreamnt  +downstreamnt
atggcttcgaccacaacctgcaccaggttcacggacgagtatcagcttttcgaggagctt
ggaaagggggcattctcagtggtgagaagatgtatgaaaattcctactggacaagaatat
gctgccaaaattatcaacaccaaaaagctttctgctagggatcatcagaaactagaaaga
gaagctagaatctgccgtcttttgaagcaccctaatattgtgcgacttcatgatagcata
tcagaagagggctttcactacttggtgtttgatttagttactggaggtgaactgtttgaa
gacatagtggcaagagaatactacagtgaagctgatgccagtcattgtatacagcagatt
ctagaaagtgttaatcattgtcacctaaatggcatagttcacagggacctgaagcctgag
aatttgcttttagctagcaaatccaagggagcagctgtgaaattggcagactttggctta
gccatagaagttcaaggggaccagcaggcgtggtttggttttgctggcacacctggatat
ctttctccagaagttttacgtaaagatccttatggaaagccagtggatatgtgggcatgt
ggtgtcattctctatattctacttgtggggtatccacccttctgggatgaagaccaacac
agactctatcagcagatcaaggctggagcttatgattttccatcaccagaatgggacacg
gtgactcctgaagccaaagacctcatcaataaaatgcttactatcaaccctgccaaacgc
atcacagcctcagaggcactgaagcacccatggatctgtcaacgttctactgttgcttcc
atgatgcacagacaggagactgtagactgcttgaagaaatttaatgctagaagaaaacta
aagggtgccatcttgacaactatgctggctacaaggaatttctcagcagccaagagtttg
ttgaagaaaccagatggagtaaaggagtcaactgagagttcaaatacaacaattgaggat
gaagatgtgaaagcacgaaagcaagagattatcaaagtcactgaacaactgatcgaagct
atcaacaatggggactttgaagcctacacaaaaatctgtgacccaggccttactgctttt
gaacctgaagctttgggtaatttagtggaagggatggattttcaccgattctactttgaa
aatgctttgtccaaaagcaataaaccaatccacactattattctaaaccctcatgtacat
ctggtaggggatgatgccgcctgcatagcatatattaggctcacacagtacatggatggc
agtggaatgccaaagacaatgcagtcagaagagactcgtgtgtggcaccgccgggatgga
aagtggcagaatgttcattttcatcgctcggggtcaccaacagtacccatcaagccaccc
tgtattccaaatgggaaagaaaacttctcaggaggcacctctttgtggcaaaacatctaa

KEGG   Homo sapiens (human): 818Help
Entry
818               CDS       T01001                                 

Gene name
CAMK2G, CAMK, CAMK-II, CAMKG
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II gamma
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
nt06220  Calcium signaling
nt06273  Glioma
nt06316  Angiotensin-aldosterone signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    818 (CAMK2G)
   04310 Wnt signaling pathway
    818 (CAMK2G)
   04066 HIF-1 signaling pathway
    818 (CAMK2G)
   04020 Calcium signaling pathway
    818 (CAMK2G)
   04024 cAMP signaling pathway
    818 (CAMK2G)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    818 (CAMK2G)
   04217 Necroptosis
    818 (CAMK2G)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    818 (CAMK2G)
   04922 Glucagon signaling pathway
    818 (CAMK2G)
   04912 GnRH signaling pathway
    818 (CAMK2G)
   04921 Oxytocin signaling pathway
    818 (CAMK2G)
   04916 Melanogenesis
    818 (CAMK2G)
   04925 Aldosterone synthesis and secretion
    818 (CAMK2G)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    818 (CAMK2G)
  09154 Digestive system
   04971 Gastric acid secretion
    818 (CAMK2G)
  09156 Nervous system
   04725 Cholinergic synapse
    818 (CAMK2G)
   04728 Dopaminergic synapse
    818 (CAMK2G)
   04720 Long-term potentiation
    818 (CAMK2G)
   04722 Neurotrophin signaling pathway
    818 (CAMK2G)
  09157 Sensory system
   04740 Olfactory transduction
    818 (CAMK2G)
   04750 Inflammatory mediator regulation of TRP channels
    818 (CAMK2G)
  09158 Development and regeneration
   04360 Axon guidance
    818 (CAMK2G)
  09159 Environmental adaptation
   04713 Circadian entrainment
    818 (CAMK2G)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    818 (CAMK2G)
   05205 Proteoglycans in cancer
    818 (CAMK2G)
  09162 Cancer: specific types
   05214 Glioma
    818 (CAMK2G)
  09165 Substance dependence
   05031 Amphetamine addiction
    818 (CAMK2G)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    818 (CAMK2G)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    818 (CAMK2G)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    818 (CAMK2G)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     818 (CAMK2G)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   818 (CAMK2G)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr SnoaL_3 DUF4440 APH Pkinase_fungal Kdo SnoaL_2 RIO1
Motif
Other DBs
NCBI-GeneID: 818
NCBI-ProteinID: NP_001191421
OMIM: 602123
HGNC: 1463
Ensembl: ENSG00000148660
Vega: OTTHUMG00000018492
Pharos: Q13555(Tchem)
UniProt: Q13555
Structure
PDB: 

Position
10q22.2
AA seq 539 aa AA seqDB search
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI
LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL
KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKPQSNNKNSL
VSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIE
AINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHV
HVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
NT seq 1620 nt NT seq  +upstreamnt  +downstreamnt
atggccaccaccgccacctgcacccgtttcaccgacgactaccagctcttcgaggagctt
ggcaagggtgctttctctgtggtccgcaggtgtgtgaagaaaacctccacgcaggagtac
gcagcaaaaatcatcaataccaagaagttgtctgcccgggatcaccagaaactagaacgt
gaggctcggatatgtcgacttctgaaacatccaaacatcgtgcgcctccatgacagtatt
tctgaagaagggtttcactacctcgtgtttgaccttgttaccggcggggagctgtttgaa
gacattgtggccagagagtactacagtgaagcagatgccagccactgtatacatcagatt
ctggagagtgttaaccacatccaccagcatgacatcgtccacagggacctgaagcctgag
aacctgctgctggcgagtaaatgcaagggtgccgccgtcaagctggctgattttggccta
gccatcgaagtacagggagagcagcaggcttggtttggttttgctggcaccccaggttac
ttgtcccctgaggtcttgaggaaagatccctatggaaaacctgtggatatctgggcctgc
ggggtcatcctgtatatcctcctggtgggctatcctcccttctgggatgaggatcagcac
aagctgtatcagcagatcaaggctggagcctatgatttcccatcaccagaatgggacacg
gtaactcctgaagccaagaacttgatcaaccagatgctgaccataaacccagcaaagcgc
atcacggctgaccaggctctcaagcacccgtgggtctgtcaacgatccacggtggcatcc
atgatgcatcgtcaggagactgtggagtgtttgcgcaagttcaatgcccggagaaaactg
aagggtgccatcctcacgaccatgcttgtctccaggaacttctcagttggcaggcagagc
tccgcccccgcctcgcctgccgcgagcgccgccggcctggccgggcaagctgccaaaagc
ctattgaacaagaagtcggatggcggtgtcaagccacagagcaacaacaaaaacagtctc
gtaagcccagcccaagagcccgcgcccttgcagacggccatggagccacaaaccactgtg
gtacacaacgctacagatgggatcaagggctccacagagagctgcaacaccaccacagaa
gatgaggacctcaaagtgcgaaaacaggagatcattaagattacagaacagctgattgaa
gccatcaacaatggggactttgaggcctacacgaagatttgtgatccaggcctcacttcc
tttgagcctgaggcccttggtaacctcgtggaggggatggatttccataagttttacttt
gagaatctcctgtccaagaacagcaagcctatccataccaccatcctaaacccacacgtc
cacgtgattggggaggacgcagcgtgcatcgcctacatccgcctcacccagtacatcgac
gggcagggtcggcctcgcaccagccagtcagaagagacccgggtctggcaccgtcgggat
ggcaagtggctcaatgtccactatcactgctcaggggcccctgccgcaccgctgcagtga

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