KEGG   Homo sapiens (human): 8189
Entry
8189              CDS       T01001                                 
Symbol
SYMPK, Pta1, SPK, SYM
Name
(RefSeq) symplekin scaffold protein
  KO
K06100  symplekin
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa04530  Tight junction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    8189 (SYMPK)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    8189 (SYMPK)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    8189 (SYMPK)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     8189 (SYMPK)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage stimulation factor (CSTF) complex
     8189 (SYMPK)
    U7-dependent histone pre-mRNA processing factors
     8189 (SYMPK)
SSDB
Motif
Pfam: Symplekin_C SYMPK_PTA1_N PDS5 Cnd1 Cohesin_HEAT
Other DBs
NCBI-GeneID: 8189
NCBI-ProteinID: NP_004810
OMIM: 602388
HGNC: 22935
Ensembl: ENSG00000125755
Pharos: Q92797(Tbio)
UniProt: Q92797
Structure
Position
19:complement(45815410..45863147)
AA seq 1274 aa
MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE
LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD
ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR
THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL
KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN
LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM
KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV
YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK
VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR
KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL
KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK
DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL
SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA
PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE
LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK
KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK
SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL
SRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVR
SFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIG
LRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECET
PGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSP
AAEDAREPEAKGNS
NT seq 3825 nt   +upstreamnt  +downstreamnt
atggcgagcggcagtggagacagcgtcacccgtcggagcgtggcatcacagtttttcact
caagaggaggggccgggcatcgatggcatgaccacctcagagagggtggtggatcttctg
aaccaggcggcgctgatcaccaatgactcaaagatcacagtgctcaaacaggtccaggag
ctgatcatcaacaaagaccccacactactggacaacttcctggatgagatcatcgcattc
caagcagacaagtcaatcgaagtgcgaaaatttgtcatcggcttcatcgaggaggcatgc
aagcgagacattgagttgctgctgaaactcattgcaaacctcaacatgctcttgagggac
gagaatgtgaacgtggtgaagaaggctatcctcaccatgacccagctctacaaggtggcc
ctgcagtggatggtaaagtcacgggtcattagcgagctacaggaggcctgctgggacatg
gtatctgccatggcgggggacatcatcctgctattggactctgacaatgacggcatccgc
acccacgccatcaagtttgtggagggcctcattgtcaccctgtcaccccgcatggctgac
tcagagataccccgacgccaggagcatgatatcagcctggaccgcatccctcgtgaccac
ccctacatccagtacaacgtgctatgggaagagggcaaggcagccttggagcagctgctt
aagttcatggtgcaccctgccatctcctccatcaacctgaccacagcgctgggctccctt
gccaatatcgcccgccagagacccatgttcatgtctgaggtgatccaggcctatgaaact
ctgcatgccaacctgcccccgacgctggccaaatcgcaggtgagcagtgtgcgtaagaat
ctgaagctgcacctgttgagtgtgctgaagcacccggcttccttggagttccaggcccag
atcaccaccctgctggtggacctgggcacacctcaggccgagatcgcccgcaacatgccg
agcagcaaggacacccgcaagcggccccgcgatgactcggactccacactcaagaagatg
aagctggagcccaacctgggggaggacgatgaggacaaagacttggagccaggcccgtcg
gggacctcgaaggcctcagcgcagatctccggccagtcagacacggacatcacagctgag
ttcctgcagcctctgctgacgcctgataatgtggctaatctggtcctcatcagcatggtg
tacctacccgaggccatgccagcctccttccaggccatctacacccccgtggagtcagca
ggcacggaagcccagatcaagcacctggctcggctcatggccacacagatgacagctgcc
ggactgggaccaggtgtagagcagaccaaacagtgcaaggaggagcccaaggaggagaag
gtggtgaagacagagagcgtcctgatcaagcggcgcctgtcagcccagggccaagccatc
tcggtggtgggttccctgagctccatgtcccccctggaggaagaggcaccgcaggccaag
aggaggccagagcccattatccctgtcactcagccccggctggcaggcgctggtgggcgc
aagaaaattttccgtctcagcgacgtgctgaagccccttaccgatgcccaggtggaagcc
atgaagctgggcgctgtgaagcggatcctgcgggctgagaaggctgtggcctgcagcggg
gcagcccaggtccgcataaagatcctggccagcctggtgacacagttcaactcgggcctg
aaggcggaggtcctgtccttcatcctggaggatgtgcgggcccgcctggacctggccttc
gcctggctctaccaggagtacaacgcctacctggccgcaggtgcctcgggctccctggac
aagtatgaggactgcctcatccgcctgttgtctggcctgcaggagaaaccagaccagaag
gatgggatcttcaccaaggttgtgctggaggcgccactcatcacagagagtgccctggag
gtggtccgcaagtactgcgaggatgagagtcgcacctatctgggcatgtccacacttcga
gacctgatcttcaagcgcccgtcccgccagttccagtacctgcatgtcctcctcgacctc
agctcccatgagaaggacaaggtgcgctcccaggccctgctgttcatcaaacgcatgtat
gagaaggagcagctgcgggagtatgtggagaaatttgccctcaactacctgcagctcctg
gtgcaccccaacccaccgtctgtgctgtttggagctgacaaggacacagaggtggcagca
ccctggacggaggagacagtgaagcagtgtctgtacctctacctggccctcctgcctcag
aaccacaagctgatccacgaactggcggccgtgtacactgaagccatcgccgacatcaag
cggacggtgctgagggtcattgagcagccgatccgaggaatgggcatgaactccccggag
ctgctcctgctggtggaaaattgtcccaagggagcagagacactggtcacgagatgtctg
cacagcctcacagacaaagtcccaccctccccagagctggtgaagcgggtccgggatctc
taccacaagcgactgccagacgtccgcttcctcatcccggtgctcaatgggctggagaag
aaagaggtgatccaggccctgcctaaactcatcaaactcaaccccatcgtggtgaaggaa
gtcttcaaccgcctgctgggcacccagcatggtgagggaaactcagccttgtccccgctg
aaccctggagagctcctgatcgcattacacaacattgactccgtgaagtgcgacatgaaa
tccatcatcaaagccaccaacctgtgctttgcggagcggaacgtgtacacgtcagaggtg
ctggccgtggtgatgcagcagctgatggagcagagccccctgcccatgctgctcatgagg
accgtcatccagtccctgaccatgtacccccgcctggggggcttcgtcatgaacatcctg
tcccgcctcatcatgaagcaggtgtggaagtaccccaaggtgtgggagggcttcatcaag
tgctgccagcgcacaaagccccagagcttccaggtcatcctgcagctgccgccccagcag
ctgggagccgtctttgacaagtgcccagagctccgggagcccctgctggcccatgtccgc
tccttcaccccccaccagcaagctcacatccctaactccatcatgaccatcttggaggcc
agcggcaagcaggagccagaggccaaggaggcgcctgcggggcccttggaggaggatgat
ctggagcccctgaccttggccccggccccagcaccccggccccctcaggacctcatcggc
ctgcgactggcccaggagaaggccttaaagcggcagctggaggaggaacagaagctgaag
ccgggaggagtgggagccccctcctcttcctccccctctccctctccgtcggcccggcca
ggcccgcccccgtctgaggaagccatggatttccgggaggaggggcctgagtgcgagacc
ccgggcatcttcatcagcatggatgacgactcggggctgaccgaggccgcgctgttggac
tctagtctcgagggccccctacccaaggagacggcagcgggcgggctgaccttgaaggag
gagcggagcccccagaccctcgcacctgttggagaagatgctatgaagactcccagcccg
gctgccgaggacgccagggaacccgaggccaaggggaacagctga

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