KEGG   Homo sapiens (human): 833
Entry
833               CDS       T01001                                 
Symbol
CARS1, CARS, CYSRS, MCDDBH, MDBH, MGC:11246
Name
(RefSeq) cysteinyl-tRNA synthetase 1
  KO
K01883  cysteinyl-tRNA synthetase [EC:6.1.1.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02132  Microcephaly syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    833 (CARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    833 (CARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    833 (CARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.16  cysteine---tRNA ligase
     833 (CARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (G)
   833 (CARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    833 (CARS1)
 Prokaryotic type
    833 (CARS1)
SSDB
Motif
Pfam: tRNA-synt_1e tRNA-synt_1g tRNA-synt_1 ROK
Other DBs
NCBI-GeneID: 833
NCBI-ProteinID: NP_001742
OMIM: 123859
HGNC: 1493
Ensembl: ENSG00000110619
Pharos: P49589(Tbio)
UniProt: P49589 A0A024RCG3
Position
11:complement(3000929..3057423)
AA seq 748 aa
MADSSGQQGKGRRVQPQWSPPAGTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVY
DASHMGHARSYISFDILRRVLKDYFKFDVFYCMNITDIDDKIIKRARQNHLFEQYREKRP
EAAQLLEDVQAALKPFSVKLNETTDPDKKQMLERIQHAVQLATEPLEKAVQSRLTGEEVN
SCVEVLLEEAKDLLSDWLDSTLGCDVTDNSIFSKLPKFWEGDFHRDMEALNVLPPDVLTR
VSEYVPEIVNFVQKIVDNGYGYVSNGSVYFDTAKFASSEKHSYGKLVPEAVGDQKALQEG
EGDLSISADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASM
DIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDA
LKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVDITGQF
EKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPN
QALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRK
IAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKEREEKRRVEEE
KRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQ
AKKLKKLFEAQEKLYKEYLQMAQNGSFQ
NT seq 2247 nt   +upstreamnt  +downstreamnt
atggcagattcctccgggcagcagggcaaaggccggcgtgtgcagccccagtggtcccct
cctgctgggacccagccatgcagactccacctttacaacagcctcaccaggaacaaggaa
gtgttcatacctcaagatgggaaaaaggtgacgtggtattgctgtgggccaaccgtctat
gacgcatctcacatggggcacgccaggtcctacatctcttttgatatcttgagaagagtg
ttgaaggattacttcaaatttgatgtcttttattgcatgaacattacggatattgatgac
aagatcatcaagagggcccggcagaaccacctgttcgagcagtatcgggagaagaggcct
gaagcggcacagctcttggaggatgttcaggccgccctgaagccattttcagtaaaatta
aatgagaccacggatcccgataaaaagcagatgctcgaacggattcagcacgcagtgcag
cttgccacagagccacttgagaaagctgtgcagtccagactcacgggagaggaagtcaac
agctgtgtggaggtgttgctggaagaagccaaggatttgctctctgactggctggattct
acacttggctgtgatgtcactgacaattccatcttctccaagctgcccaagttctgggag
ggggacttccacagagacatggaagctctgaatgttctccctccagatgtcttaacccgg
gttagtgagtatgtgccagaaattgtgaactttgtccagaagattgtggacaacggttac
ggctatgtctccaatgggtctgtctactttgatacagcgaagtttgcttctagcgagaag
cactcctatgggaagctggtgcctgaggccgttggagatcagaaagcccttcaagaaggg
gaaggtgacctgagcatctctgcagaccgcctgagtgagaagcgctctcccaacgacttt
gccttatggaaggcctctaagcccggagaaccgtcctggccgtgcccttggggaaagggt
cgtccgggctggcatatcgagtgctcggccatggcaggcaccctcctaggggcttcgatg
gacattcacggaggtgggttcgacctccggttcccccaccatgacaatgagctggcacag
tcggaggcctactttgaaaacgactgctgggtcaggtacttcctgcacacaggccacctg
accattgcaggctgcaaaatgtcaaagtcactaaaaaacttcatcaccattaaagatgcc
ttgaaaaagcactcagcacggcagttgcggctggccttcctcatgcactcgtggaaggac
accctggactactccagcaacaccatggagtcagcgcttcaatatgagaagttcttgaat
gagtttttcttaaatgtgaaagatatccttcgcgctcctgttgacatcactggtcagttt
gagaagtggggagaagaagaagcagaactgaataagaacttttatgacaagaagacagca
attcacaaagccctctgtgacaatgttgacacccgcaccgtcatggaagagatgcgggcc
ttggtcagtcagtgcaacctctatatggcagcccggaaagccgtgaggaagaggcccaac
caggctctgctggagaacatcgccctgtacctcacccatatgctgaagatctttggggcc
gtagaagaggacagctccctgggattcccggtcggagggcctggaaccagcctcagtctc
gaggccacagtcatgccctaccttcaggtgttatcagaattccgagaaggagtgcggaag
attgcccgagagcaaaaagtccctgagattctgcagctcagcgatgccctgcgggacaac
atcctgcccgagcttggggtgcggtttgaagaccacgaaggactgcccacagtggtgaaa
ctggtagacagaaacaccttattaaaagagagagaagaaaagagacgggttgaagaggag
aagaggaagaagaaagaggaggcggcccggaggaaacaggaacaagaagcagcaaagctg
gccaagatgaagattccccccagtgagatgttcttgtcagaaaccgacaaatactccaag
tttgatgaaaatggtctgcccacacatgacatggagggcaaagagctcagcaaagggcaa
gccaagaagctgaagaagctcttcgaggctcaggagaagctctacaaggaatatctgcag
atggcccagaatggaagcttccagtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
   PHAROS (1)   
Protein sequence (15)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (61)   
   RefSeq(nuc) (17)   
   GenBank (22)   
   EMBL (22)   
Protein domain (4)   
   Pfam (4)   
All databases (123)   

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