KEGG   Homo sapiens (human): 8395Help
Entry
8395              CDS       T01001                                 

Gene name
PIP5K1B, MSS4, STM7
Definition
(RefSeq) phosphatidylinositol-4-phosphate 5-kinase type 1 beta
  KO
K00889  1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04072  Phospholipase D signaling pathway
hsa04144  Endocytosis
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05231  Choline metabolism in cancer
Module
hsa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    8395 (PIP5K1B)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    8395 (PIP5K1B)
   04072 Phospholipase D signaling pathway
    8395 (PIP5K1B)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    8395 (PIP5K1B)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    8395 (PIP5K1B)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    8395 (PIP5K1B)
 09160 Human Diseases
  09161 Cancers
   05231 Choline metabolism in cancer
    8395 (PIP5K1B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8395 (PIP5K1B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.68  1-phosphatidylinositol-4-phosphate 5-kinase
     8395 (PIP5K1B)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    8395 (PIP5K1B)
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    8395 (PIP5K1B)
 Endosome - Golgi transport
  Others
   Others
    8395 (PIP5K1B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PIP5K
Motif
Other DBs
NCBI-GeneID: 8395
NCBI-ProteinID: NP_003549
OMIM: 602745
HGNC: 8995
Ensembl: ENSG00000107242
Vega: OTTHUMG00000019976
Pharos: O14986(Tbio)
UniProt: O14986 Q7KYT6
Position
9q21.11
AA seq 540 aa AA seqDB search
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVV
ESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNP
GASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGG
INIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYF
DTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQ
KVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKK
LEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKAT
SQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTIS
SSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL
NT seq 1623 nt NT seq  +upstreamnt  +downstreamnt
atgtcttctgctgctgaaaatggagaggcagcacctggaaaacaaaatgaagaaaaaacc
tataaaaagactgcatcatctgctattaaaggtgctattcagctgggaataggatacaca
gtgggtaatctcacttccaagccagaacgagatgttcttatgcaagacttttatgtggtg
gaaagtgtgttcctacccagcgaagggagcaatctgaccccagcacatcactacccagac
tttagatttaagacatacgctccattagcattccgatatttcagagaactttttggtatc
aagcctgatgattacttgtattccatctgcagtgaacctctaatagaactgtctaaccct
ggagccagtggatccttgttttttgtgaccagtgatgatgaatttatcatcaaaacagtt
cagcacaaagaagctgagtttcttcagaagctactgccaggctattacatgaatttaaac
cagaatccaaggactcttttgccaaaattttacggactgtattgtatgcaatcaggaggc
attaatatcaggattgtggtgatgaacaacgttttgccacgctccatgagaatgcacttt
acatatgacttgaaaggctcaacgtataagcgaagagcatcccgtaaagagagagagaaa
tccaaccccacatttaaggacttagatttcctgcaagacatgcacgaagggttgtatttt
gatacggaaacatacaacgcgcttatgaaaacacttcagagagactgccgggtgctagaa
agcttcaagatcatggattatagccttctgttgggaattcatttcctggaccattccctc
aaagagaaagaggaggagaccccacaaaatgtgcctgatgctaagcggactgggatgcag
aaggttctctactcaacagccatggaatctatccagggtccagggaaatctggagatggg
ataatcacagagaacccagacacaatgggaggcattccagctaaaagccataggggagaa
aaactacttttatttatgggcattattgacattctgcaatcatataggttaatgaagaag
ttagaacattcctggaaagctcttgtttatgatggggacactgtttctgttcatagacca
agcttttatgcagacagatttcttaagttcatgaattccagagttttcaagaaaattcaa
gctttgaaggcttcaccgtctaagaaacggtgcaattcaatcgccgccctaaaggccact
tcacaggagattgtgtcctcaattagccaggaatggaaggatgagaagcgggatttgctg
actgaaggacaaagttttagcagccttgatgaagaagccctgggatcccgacacaggcca
gacctggtccctagcactccatcactgtttgaagctgcttccttggcaaccacaatttca
tcttcttccttatacgtcaatgagcactatccacacgacaggcctacactctattcaaac
agcaaagggttaccttccagttcaacatttaccttggaagaggggaccatctacttgacc
gctgagcccaacactctggaagtgcaggatgacaatgcttctgtgcttgacgtctattta
taa

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