KEGG   Homo sapiens (human): 8399
Entry
8399              CDS       T01001                                 

Gene name
PLA2G10, GXPLA2, GXSPLA2, SPLA2, sPLA2-X
Definition
(RefSeq) phospholipase A2 group X
  KO
K01047  secretory phospholipase A2 [EC:3.1.1.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa00565  Ether lipid metabolism
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00592  alpha-Linolenic acid metabolism
hsa01100  Metabolic pathways
hsa04014  Ras signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04972  Pancreatic secretion
hsa04975  Fat digestion and absorption
Drug target
Varespladib (DG01394): D06283
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    8399 (PLA2G10)
   00565 Ether lipid metabolism
    8399 (PLA2G10)
   00590 Arachidonic acid metabolism
    8399 (PLA2G10)
   00591 Linoleic acid metabolism
    8399 (PLA2G10)
   00592 alpha-Linolenic acid metabolism
    8399 (PLA2G10)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    8399 (PLA2G10)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    8399 (PLA2G10)
  09154 Digestive system
   04972 Pancreatic secretion
    8399 (PLA2G10)
   04975 Fat digestion and absorption
    8399 (PLA2G10)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8399 (PLA2G10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     8399 (PLA2G10)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centriole proteins
    8399 (PLA2G10)
SSDB
Motif
Pfam: Phospholip_A2_1
Other DBs
NCBI-GeneID: 8399
NCBI-ProteinID: NP_003552
OMIM: 603603
HGNC: 9029
Ensembl: ENSG00000069764
Vega: OTTHUMG00000048069
Pharos: O15496(Tchem)
UniProt: O15496
Structure
PDB: 

Position
16p13.12
AA seq 165 aa
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPI
AYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGP
AENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
NT seq 498 nt   +upstreamnt  +downstreamnt
atggggccgctacctgtgtgcctgccaatcatgctgctcctgctactgccgtcgctgctg
ctgctgctgcttctacctggccccgggtccggcgaggcctccaggatattacgtgtgcac
cggcgtgggatcctggaactggcaggaactgtgggttgtgttggtccccgaacccccatc
gcctatatgaaatatggttgcttttgtggcttgggaggccatggccagccccgcgatgcc
attgactggtgctgccatggccacgactgttgttacactcgagctgaggaggccggctgc
agccccaagacagagcgctactcctggcagtgcgtcaatcagagcgtcctgtgcggaccg
gcagagaacaaatgccaagaactgttgtgcaagtgtgaccaggagattgctaactgctta
gcccaaactgagtacaacttaaagtacctcttctacccccagttcctatgtgagccggac
tcgcccaagtgtgactga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (14)   
   KEGG COMPOUND (14)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (20)   
   RefSeq(nuc) (6)   
   GenBank (7)   
   EMBL (7)   
Protein domain (1)   
   Pfam (1)   
All databases (89)   

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