KEGG   Homo sapiens (human): 841
Entry
841               CDS       T01001                                 

Gene name
CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Definition
(RefSeq) caspase 8
  KO
K04398  caspase 8 [EC:3.4.22.61]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04217  Necroptosis
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05134  Legionellosis
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05416  Viral myocarditis
Network
nt06131  Apoptosis (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06231  Apoptosis
nt06263  Hepatocellular carcinoma
nt06414  Apoptosis
nt06460  Alzheimer disease
nt06461  Huntington disease
  Element
N00145  Extrinsic apoptotic pathway
N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
N00166  KSHV vFLIP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00352  HPV E6 to extrinsic apoptotic pathway
N00425  HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00526  HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00527  HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
N00528  HCV core to extrinsic apoptotic pathway
N00579  HSV ICP6 to extrinsic apoptotic pathway
N00937  Escherichia NleF to extrinsic apoptotic pathway
N00983  Mutation-caused aberrant Htt to extrinsic apoptotic pathway
N01005  Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
Disease
H00108  Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    841 (CASP8)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    841 (CASP8)
   04215 Apoptosis - multiple species
    841 (CASP8)
   04217 Necroptosis
    841 (CASP8)
   04115 p53 signaling pathway
    841 (CASP8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    841 (CASP8)
   04621 NOD-like receptor signaling pathway
    841 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    841 (CASP8)
   04625 C-type lectin receptor signaling pathway
    841 (CASP8)
   04657 IL-17 signaling pathway
    841 (CASP8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    841 (CASP8)
   05203 Viral carcinogenesis
    841 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    841 (CASP8)
   05016 Huntington disease
    841 (CASP8)
   05022 Pathways of neurodegeneration - multiple diseases
    841 (CASP8)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    841 (CASP8)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    841 (CASP8)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    841 (CASP8)
   05132 Salmonella infection
    841 (CASP8)
   05134 Legionellosis
    841 (CASP8)
   05152 Tuberculosis
    841 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    841 (CASP8)
   05161 Hepatitis B
    841 (CASP8)
   05160 Hepatitis C
    841 (CASP8)
   05164 Influenza A
    841 (CASP8)
   05162 Measles
    841 (CASP8)
   05168 Herpes simplex virus 1 infection
    841 (CASP8)
   05163 Human cytomegalovirus infection
    841 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    841 (CASP8)
   05169 Epstein-Barr virus infection
    841 (CASP8)
   05165 Human papillomavirus infection
    841 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    841 (CASP8)
   05142 Chagas disease
    841 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    841 (CASP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    841 (CASP8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     841 (CASP8)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C14: caspase family
   841 (CASP8)
SSDB
Motif
Pfam: Peptidase_C14 DED PYRIN
Other DBs
NCBI-GeneID: 841
NCBI-ProteinID: NP_203519
OMIM: 601763
HGNC: 1509
Ensembl: ENSG00000064012
Vega: OTTHUMG00000132821
Pharos: Q14790(Tchem)
UniProt: Q14790
Structure
PDB: 

Position
2q33.1
AA seq 479 aa
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
NT seq 1440 nt   +upstreamnt  +downstreamnt
atggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcc
tccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggat
gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtcc
ttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaac
actagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcc
tacagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtctttt
aagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctg
gatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctg
aaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaa
ttcagcaaagagagaagcagcagccttgaaggaagtcctgatgaattttcaaatggggag
gagttgtgtggggtaatgacaatctcggactctccaagagaacaggatagtgaatcacag
actttggacaaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaac
aatcacaattttgcaaaagcacgggagaaagtgcccaaacttcacagcattagggacagg
aatggaacacacttggatgcaggggctttgaccacgacctttgaagagcttcattttgag
atcaagccccacgatgactgcacagtagagcaaatctatgagattttgaaaatctaccaa
ctcatggaccacagtaacatggactgcttcatctgctgtatcctctcccatggagacaag
ggcatcatctatggcactgatggacaggaggcccccatctatgagctgacatctcagttc
actggtttgaagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgt
cagggggataactaccagaaaggtatacctgttgagactgattcagaggagcaaccctat
ttagaaatggatttatcatcacctcaaacgagatatatcccggatgaggctgactttctg
ctggggatggccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctgg
tacatccagtcactttgccagagcctgagagagcgatgtcctcgaggcgatgatattctc
accatcctgactgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatgggg
aaacagatgcctcagcctactttcacactaagaaaaaaacttgtcttcccttctgattga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (34)   
   KEGG PATHWAY (34)   
Network (13)   
   KEGG NETWORK (13)   
Disease (5)   
   KEGG DISEASE (1)   
   OMIM (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (13)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (23)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (21)   
DNA sequence (99)   
   RefSeq(nuc) (25)   
   GenBank (37)   
   EMBL (37)   
Protein domain (3)   
   Pfam (3)   
All databases (209)   

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