KEGG T01001: 841

nt06131  Apoptosis (viruses)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06231  Apoptosis
nt06263  Hepatocellular carcinoma

Element

N00145

Extrinsic apoptotic pathway

N00146

Crosstalk between extrinsic and intrinsic apoptotic pathways

N00350

HPV E6 to extrinsic apoptotic pathway

N00351

HPV E6 to extrinsic apoptotic pathway

N00352

HPV E6 to extrinsic apoptotic pathway

N00425

HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways

N00449

HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways

N00524

HCV NS5A to extrinsic apoptotic pathway

N00526

HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways

N00527

HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways

N00528

HCV core to extrinsic apoptotic pathway

N00579

HSV ICP6 to extrinsic apoptotic pathway

Disease

H00108

Autoimmune lymphoproliferative syndromes

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    841 (CASP8)
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    841 (CASP8)
   04215 Apoptosis - multiple species
    841 (CASP8)
   04217 Necroptosis
    841 (CASP8)
   04115 p53 signaling pathway
    841 (CASP8)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    841 (CASP8)
   04621 NOD-like receptor signaling pathway
    841 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    841 (CASP8)
   04625 C-type lectin receptor signaling pathway
    841 (CASP8)
   04657 IL-17 signaling pathway
    841 (CASP8)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    841 (CASP8)
   05203 Viral carcinogenesis
    841 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    841 (CASP8)
   05016 Huntington disease
    841 (CASP8)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    841 (CASP8)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    841 (CASP8)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    841 (CASP8)
   05134 Legionellosis
    841 (CASP8)
   05152 Tuberculosis
    841 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    841 (CASP8)
   05162 Measles
    841 (CASP8)
   05164 Influenza A
    841 (CASP8)
   05161 Hepatitis B
    841 (CASP8)
   05160 Hepatitis C
    841 (CASP8)
   05168 Herpes simplex virus 1 infection
    841 (CASP8)
   05163 Human cytomegalovirus infection
    841 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    841 (CASP8)
   05169 Epstein-Barr virus infection
    841 (CASP8)
   05165 Human papillomavirus infection
    841 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    841 (CASP8)
   05142 Chagas disease (American trypanosomiasis)
    841 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    841 (CASP8)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    841 (CASP8)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     841 (CASP8)
Peptidases and inhibitors [BR:hsa01002]
Cysteine peptidases
  Family C14: caspase family
   841 (CASP8)

SSDB

Motif

Pfam:

Peptidase_C14 DED PYRIN

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q14790(Tchem)

UniProt:

Q14790

Structure

PDB:

4JJ7 1QTN 4PS1 2Y1L 3KJN 3KJQ 3H11 2C2Z 6AGW 4PRZ 4ZBW 1QDU 1F9E 2FUN 1I4E 5H31 5H33 5L08 2K7Z

Position

2q33.1

AA seq 479 aa
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

NT seq 1440 nt +upstreamnt +downstreamnt
atggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcc
tccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggat
gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtcc
ttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaac
actagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcc
tacagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtctttt
aagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctg
gatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctg
aaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaa
ttcagcaaagagagaagcagcagccttgaaggaagtcctgatgaattttcaaatggggag
gagttgtgtggggtaatgacaatctcggactctccaagagaacaggatagtgaatcacag
actttggacaaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaac
aatcacaattttgcaaaagcacgggagaaagtgcccaaacttcacagcattagggacagg
aatggaacacacttggatgcaggggctttgaccacgacctttgaagagcttcattttgag
atcaagccccacgatgactgcacagtagagcaaatctatgagattttgaaaatctaccaa
ctcatggaccacagtaacatggactgcttcatctgctgtatcctctcccatggagacaag
ggcatcatctatggcactgatggacaggaggcccccatctatgagctgacatctcagttc
actggtttgaagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgt
cagggggataactaccagaaaggtatacctgttgagactgattcagaggagcaaccctat
ttagaaatggatttatcatcacctcaaacgagatatatcccggatgaggctgactttctg
ctggggatggccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctgg
tacatccagtcactttgccagagcctgagagagcgatgtcctcgaggcgatgatattctc
accatcctgactgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatgggg
aaacagatgcctcagcctactttcacactaagaaaaaaacttgtcttcccttctgattga

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