KEGG   Homo sapiens (human): 84699Help
Entry
84699             CDS       T01001                                 

Gene name
CREB3L3, CREB-H, CREBH, HYST1481
Definition
(RefSeq) cAMP responsive element binding protein 3 like 3
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing's syndrome
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington's disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05203  Viral carcinogenesis
hsa05215  Prostate cancer
Network
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    84699 (CREB3L3)
   04024 cAMP signaling pathway
    84699 (CREB3L3)
   04022 cGMP - PKG signaling pathway
    84699 (CREB3L3)
   04151 PI3K-Akt signaling pathway
    84699 (CREB3L3)
   04152 AMPK signaling pathway
    84699 (CREB3L3)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    84699 (CREB3L3)
   04922 Glucagon signaling pathway
    84699 (CREB3L3)
   04915 Estrogen signaling pathway
    84699 (CREB3L3)
   04926 Relaxin signaling pathway
    84699 (CREB3L3)
   04918 Thyroid hormone synthesis
    84699 (CREB3L3)
   04928 Parathyroid hormone synthesis, secretion and action
    84699 (CREB3L3)
   04916 Melanogenesis
    84699 (CREB3L3)
   04925 Aldosterone synthesis and secretion
    84699 (CREB3L3)
   04927 Cortisol synthesis and secretion
    84699 (CREB3L3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    84699 (CREB3L3)
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    84699 (CREB3L3)
  Nervous system
   04725 Cholinergic synapse
    84699 (CREB3L3)
   04728 Dopaminergic synapse
    84699 (CREB3L3)
  Aging
   04211 Longevity regulating pathway - mammal
    84699 (CREB3L3)
  Environmental adaptation
   04714 Thermogenesis
    84699 (CREB3L3)
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    84699 (CREB3L3)
   05215 Prostate cancer
    84699 (CREB3L3)
  Neurodegenerative diseases
   05016 Huntington's disease
    84699 (CREB3L3)
  Substance dependence
   05030 Cocaine addiction
    84699 (CREB3L3)
   05031 Amphetamine addiction
    84699 (CREB3L3)
   05034 Alcoholism
    84699 (CREB3L3)
  Endocrine and metabolic diseases
   04931 Insulin resistance
    84699 (CREB3L3)
   04934 Cushing's syndrome
    84699 (CREB3L3)
  Infectious diseases
   05161 Hepatitis B
    84699 (CREB3L3)
   05163 Human cytomegalovirus infection
    84699 (CREB3L3)
   05165 Human papillomavirus infection
    84699 (CREB3L3)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  Basic leucine zipper (bZIP)
   CREB
    84699 (CREB3L3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf IncA KASH_CCD DUF2207 APG6
Motif
Other DBs
NCBI-GeneID: 84699
NCBI-ProteinID: NP_115996
OMIM: 611998
HGNC: 18855
Ensembl: ENSG00000060566
Vega: OTTHUMG00000181846
Pharos: Q68CJ9(Tbio)
UniProt: Q68CJ9
Position
19p13.3
AA seq 461 aa AA seqDB search
MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDS
DDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGK
GPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTV
KDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYE
ERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLL
EQLKKLQAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFS
RTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGSPGADWGFQDTANLTNSTEELDN
ATLVLRNATEGLGQVALLDWVAPGPSTGSGRAGLEAAGDEL
NT seq 1386 nt NT seq  +upstreamnt  +downstreamnt
atgaatacggatttagctgctggaaagatggcttctgctgcctgctccatggaccccatc
gacagctttgagctcctggatctcctgtttgaccggcaggacggcatcctgagacacgtg
gagctgggcgagggctggggtcacgtcaaggaccagcaggtcctgccaaaccccgactct
gacgacttcctcagctccatcctgggctctggagactcactgcccagctccccactctgg
tcccccgaaggcagtgatagtggcatctccgaagacctcccctccgacccccaggacacc
cctccacgcagcggaccagccacctcccccgccggctgccatcctgcccagcctggcaag
gggccctgcctctcctatcatcctggcaactcttgctccaccacaaccccagggccagtg
atccaagtacctgaagcctctgtgaccatagacctggaaatgtggagcccaggaggaagg
atctgtgctgagaagccggctgatccggtggacctgtccccacgatgcaatctcaccgtg
aaagacctcctcctttcgggcagcagtggggacctgcaacagcatcacctgggggcctcc
tacctcctgcgacctggggctgggcactgtcaggagctggtgctcaccgaggatgagaag
aagctgctggctaaagaaggcatcaccctgcccactcagctgcccctcactaagtacgag
gagcgagtgctgaaaaaaatccgccggaaaatccggaacaagcagtcggcgcaagaaagc
aggaagaagaagaaggaatatatcgatggcctggagactcggatgtcagcttgcactgct
cagaatcaggagttacagaggaaagtcttgcatctcgagaagcaaaacctgtccctcttg
gagcaactgaagaaactccaggccattgtggtgcagtccaccagcaagtcagcccagaca
ggcacctgtgtcgcagtcctgttgctgtcctttgccctcatcatcctcccctccatcagc
ccttttggccccaacaaaaccgagagccctggggactttgcgcctgtacgagtgttctcc
agaactttgcacaacgatgctgcctcccgcgtggctgctgatgctgtgccaggctccgag
gccccaggaccccgacccgaggctgacacaacccgagaagagtctccaggaagccccggg
gcagactggggcttccaggacaccgcgaacctgaccaattcgacggaggagctggacaac
gccaccctggtcctgaggaatgcaacagaggggctgggccaggtcgccctgctggactgg
gtggcgcctgggccgagcactggctcaggacgtgcagggctggaggcggcgggagacgag
ctgtga

DBGET integrated database retrieval system