KEGG   Homo sapiens (human): 84867
Entry
84867             CDS       T01001                                 
Symbol
PTPN5, PTPSTEP, STEP, STEP61
Name
(RefSeq) tyrosine-protein phosphatase non-receptor type 5 isoform a
  KO
K18018  tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    84867 (PTPN5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    84867 (PTPN5)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     84867 (PTPN5)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    84867 (PTPN5)
SSDB
Motif
Pfam: Y_phosphatase Tc-R-P PTP-SAK DSPc PTP-NADK Y_phosphatase3
Other DBs
NCBI-GeneID: 84867
NCBI-ProteinID: NP_008837
OMIM: 176879
HGNC: 9657
Ensembl: ENSP00000351342.2
UniProt: P54829 Q86TL3
Structure
Position
11:complement(18727928..18792721)
AA seq 565 aa
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPP
PPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLV
SSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPED
RRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQ
ERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLL
QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIR
GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYD
GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQ
TCEQYQFVHHVMSLYEKQLSHQSPE
NT seq 1698 nt   +upstreamnt  +downstreamnt
atgaattatgagggagccaggagtgagagagagaaccacgctgctgatgactccgaggga
ggggccctggacatgtgctgcagtgagaggctaccgggtctcccccagccgatagtgatg
gaggcactggacgaggctgaagggctccaggactcacagagagagatgccgccaccccct
cctccctcgccgccctcagatccagctcagaagccaccacctcgaggcgctgggagccac
tccctcactgtcaggagcagcctgtgcctgttcgctgcctcacagttcctgcttgcctgt
ggggtgctctggttcagcggttatggccacatctggtcacagaacgccacaaacctcgtc
tcctctttgctgacgctcctgaaacagctggaacccacggcctggcttgactctgggacg
tggggagtccccagtctgctgctggtctttctgtccgtgggcctggtcctcgttaccacc
ctggtgtggcacctcctgaggacacccccagagccacccaccccactgccccctgaggac
aggcgccagtcagtgagccgccagccctccttcacctactcagagtggatggaggagaag
atcgaggatgacttcctggacctcgacccggtgcccgagactcctgtgtttgattgtgtg
atggacatcaagcctgaggctgaccccacctcactcaccgtcaagtccatgggtctgcag
gagaggaggggttccaatgtctccctgaccctggacatgtgcactccgggctgcaacgag
gagggctttggctatctcatgtccccacgtgaggagtccgcccgcgagtacctgctcagc
gcctcccgtgtcctccaagcagaagagcttcatgaaaaggccctggaccctttcctgctg
caggcggaattctttgaaatccccatgaactttgtggatccgaaagagtacgacatccct
gggctggtgcggaagaaccggtacaaaaccatacttcccaaccctcacagcagagtgtgt
ctgacctcaccagaccctgacgaccctctgagttcctacatcaatgccaactacatccgg
ggctatggtggggaggagaaggtgtacatcgccactcagggacccatcgtcagcacggtc
gccgacttctggcgcatggtgtggcaggagcacacgcccatcattgtcatgatcaccaac
atcgaggagatgaacgagaaatgcaccgagtattggccggaggagcaggtggcgtacgac
ggtgttgagatcactgtgcagaaagtcattcacacggaggattaccggctgcgactcatc
tccctcaagagtgggactgaggagcgaggcctgaagcattactggttcacatcctggccc
gaccagaagaccccagaccgggcccccccactcctgcacctggtgcgggaggtggaggag
gcagcccagcaggaggggccccactgtgcccccatcatcgtccactgcagtgcagggatt
gggaggaccggctgcttcattgccaccagcatctgctgccagcagctgcggcaggagggt
gtggtggacatcctgaagaccacgtgccagctccgtcaggacaggggcggcatgatccag
acatgcgagcagtaccagtttgtgcaccacgtcatgagcctctacgaaaagcagctgtcc
caccagtccccagaatga

  All links  
Disease (1)   
   OMIM (1)   
Gene (17)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (21)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (18)   
DNA sequence (42)   
   RefSeq(nuc) (18)   
   GenBank (12)   
   EMBL (12)   
3D Structure (13)   
   PDB (13)   
Protein domain (6)   
   Pfam (6)   
All databases (100)   

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