KEGG   Homo sapiens (human): 84876
Entry
84876             CDS       T01001                                 
Symbol
ORAI1, CRACM1, IMD9, ORAT1, TAM2, TMEM142A
Name
(RefSeq) ORAI calcium release-activated calcium modulator 1
  KO
K16056  calcium release-activated calcium channel protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04611  Platelet activation
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa05340  Primary immunodeficiency
Network
nt06528  Calcium signaling
  Element
N01643  Ca2+ entry, Store-operated Ca2+ channel
Disease
H00093  Combined immunodeficiency
H02258  Tubular aggregate myopathy
Drug target
Zegocractin: D13009
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    84876 (ORAI1)
   04024 cAMP signaling pathway
    84876 (ORAI1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    84876 (ORAI1)
  09152 Endocrine system
   04924 Renin secretion
    84876 (ORAI1)
   04925 Aldosterone synthesis and secretion
    84876 (ORAI1)
   04927 Cortisol synthesis and secretion
    84876 (ORAI1)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    84876 (ORAI1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    84876 (ORAI1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    84876 (ORAI1)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   84876 (ORAI1)
SSDB
Motif
Pfam: Orai-1 DUF4153
Other DBs
NCBI-GeneID: 84876
NCBI-ProteinID: NP_116179
OMIM: 610277
HGNC: 25896
Ensembl: ENSG00000276045
UniProt: Q96D31
Structure
Position
12:121626530..121643109
AA seq 301 aa
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
NT seq 906 nt   +upstreamnt  +downstreamnt
atgcatccggagcccgccccgcccccgagccgcagcagtcccgagcttcccccaagcggc
ggcagcaccaccagcggcagccgccggagccgccgccgcagcggggacggggagcccccg
ggggccccgccaccgccgccgtccgccgtcacctacccggactggatcggccagagttac
tccgaggtgatgagcctcaacgagcactccatgcaggcgctgtcctggcgcaagctctac
ttgagccgcgccaagcttaaagcctccagccggacctcggctctgctctccggcttcgcc
atggtggcaatggtggaggtgcagctggacgctgaccacgactacccaccggggctgctc
atcgccttcagtgcctgcaccacagtgctggtggctgtgcacctgtttgcgctcatgatc
agcacctgcatcctgcccaacatcgaggcggtgagcaacgtgcacaatctcaactcggtc
aaggagtccccccatgagcgcatgcaccgccacatcgagctggcctgggccttctccacc
gtcatcggcacgctgctcttcctagctgaggtggtgctgctctgctgggtcaagttcttg
cccctcaagaagcagccaggccagccaaggcccaccagcaagccccccgccagtggcgca
gcagccaacgtcagcaccagcggcatcaccccgggccaggcagctgccatcgcctcgacc
accatcatggtgcccttcggcctgatctttatcgtcttcgccgtccacttctaccgctca
ctggttagccataagactgaccgacagttccaggagctcaacgagctggcggagtttgcc
cgcttacaggaccagctggaccacagaggggaccaccccctgacgcccggcagccactat
gcctag

  All links  
Disease (3)   
   OMIM (3)   
Gene (30)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (19)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (20)   
   RefSeq(nuc) (2)   
   GenBank (9)   
   EMBL (9)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (60)   

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