KEGG   Homo sapiens (human): 8516
Entry
8516              CDS       T01001                                 
Symbol
ITGA8
Name
(RefSeq) integrin subunit alpha 8
  KO
K06584  integrin alpha 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04514  Cell adhesion molecules
hsa04810  Regulation of actin cytoskeleton
hsa04820  Cytoskeleton in muscle cells
hsa05165  Human papillomavirus infection
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
  Element
N00393  ITGA/B-RhoGAP-RhoA signaling pathway
N00951  ITGA/B-RHOG-RAC signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01070  ITGA/B-FAK-CDC42 signaling pathway
N01072  ITGA/B-RhoGEF-RhoA signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
Disease
H00822  Renal hypodysplasia and aplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    8516 (ITGA8)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    8516 (ITGA8)
   04514 Cell adhesion molecules
    8516 (ITGA8)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    8516 (ITGA8)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    8516 (ITGA8)
   04810 Regulation of actin cytoskeleton
    8516 (ITGA8)
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    8516 (ITGA8)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    8516 (ITGA8)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    8516 (ITGA8)
   05414 Dilated cardiomyopathy
    8516 (ITGA8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    8516 (ITGA8)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   8516 (ITGA8)
SSDB
Motif
Pfam: Integrin_A_Ig_3 Integrin_A_Ig_2 Integrin_A_Ig_1 FG-GAP FG-GAP_3 Integrin_alpha ITGAX-like_Ig_3
Other DBs
NCBI-GeneID: 8516
NCBI-ProteinID: NP_003629
OMIM: 604063
HGNC: 6144
Ensembl: ENSG00000077943
UniProt: P53708 B4DN28
Position
10:complement(15513954..15719922)
AA seq 1063 aa
MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYA
VDFHIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIR
VNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSA
YAEFSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASVADIIANY
SFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSI
INSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQI
YLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVL
IYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAV
YRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMA
EVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPI
NISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKH
QVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENV
TRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQIN
ITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTIL
EVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIP
HLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQ
RKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAIL
LGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTPEA
NT seq 3192 nt   +upstreamnt  +downstreamnt
atgtcgcccggggccagccgcggtccccggggaagccaggcgccgctgatcgcgcccctc
tgctgcgccgcggccgcgctggggatgttgctgtggtcccccgcctgtcaggcgttcaac
ctggacgtggaaaagctcacagtgtacagcggccccaagggcagctacttcggctacgcc
gtggacttccacatacccgacgcccgcacagcgagtgtcttggtgggggcgcccaaagcc
aacaccagccagcccgatatcgtggaagggggagccgtctattactgtccttggcccgcg
gaggggtctgcgcagtgcaggcagataccgtttgacaccaccaacaacagaaagatcaga
gttaatggaaccaaagaacctatcgagttcaaatccaatcagtggtttggagcaacagtg
aaagctcacaaaggaaaagttgtggcctgtgctcctttatatcactggagaactcttaaa
ccgacaccagaaaaggacccagttggcacctgctatgtagcaattcagaacttcagcgcc
tatgccgagttctctccttgccggaacagcaatgctgatccggaaggccagggttactgc
caagcaggatttagtctggatttttataagaatggagaccttattgtgggaggacctggg
agtttctactggcaaggacaagtgatcactgccagtgttgcagatatcattgcaaattac
tcattcaaggatatcctcaggaaactggcaggagaaaagcagacggaagtggctccagct
tcctatgatgacagttaccttggatactcagttgctgctggggagtttactggggattct
cagcaagaattggttgctggaattccaagaggagcacagaattttggatatgtttccatc
attaactctacggatatgacgtttattcagaatttcacgggagaacagatggcatcttat
tttggatataccgttgtcgtatcagatgttaacagtgatggactggatgatgtcctggtt
ggggcacctctctttatggaacgtgaatttgagagcaaccccagagaagtagggcaaatc
tacctgtatttgcaagtgagctctctcctcttcagagacccccagatcctcactggcacc
gagacgtttgggagattcggtagtgctatggcacacttaggagacctgaaccaagatgga
tacaatgacattgccatcggagtgccttttgcaggcaaggatcaaagaggcaaagtgctc
atttataatgggaacaaagatggcttaaacaccaagccttcccaagttctgcaaggagtg
tgggcctcacatgctgtcccttccggatttggctttactttaagaggagattcagacata
gacaagaatgattacccagatttgattgtgggtgcatttggaacaggaaaagtcgctgtt
tacagagcaagaccggttgtgactgtagatgcccagcttctgctgcacccaatgattatc
aatcttgaaaataaaacttgccaggttccagactctatgacatctgctgcctgcttttct
ttaagagtatgtgcatctgtcacaggccagagcattgcaaacacaatagtcttgatggca
gaggtgcaattagattccctgaaacagaaaggagctattaaacggacgctcttccttgat
aaccatcaggctcatcgcgtcttccctcttgtgataaaaaggcagaaatcccaccagtgc
caggatttcatcgtttaccttcgagatgaaactgaattccgagataaattatctccaatc
aacattagtttgaattacagtttggacgaatccacctttaaagaaggcctggaagtgaaa
ccaatattgaactactacagagaaaacattgttagtgaacaggctcacattctggtggac
tgtggagaagacaatctgtgtgttcctgacttgaagctgtcggctagaccagataagcat
caggtaatcattggagatgaaaatcaccttatgctcataataaatgcaagaaatgaaggg
gaaggagcatatgaagctgaactctttgtaatgataccagaagaggcagattatgttgga
atcgaacgcaacaacaagggatttcgaccactgagctgtgagtacaagatggaaaatgta
accaggatggtggtgtgtgaccttgggaaccctatggtgtctggaacaaattattccctg
ggcctccgatttgcagttccacgtcttgagaaaacaaacatgagcattaacttcgatctc
caaatcagaagttccaacaaggacaatccagacagcaattttgtgagcctgcaaatcaac
atcactgctgtagcgcaggtggaaataagaggagtgtcacaccctccgcagattgttctg
cccattcataactgggaaccagaagaggagccccacaaagaggaggaggttggaccattg
gtggaacatatttatgagctgcacaatattggaccaagtaccatcagtgacaccatcctg
gaggtgggctggcctttctctgcccgggatgaatttcttctctatattttccatattcaa
actctgggacctctgcagtgccaaccaaatcctaatatcaatccacaggatataaagcct
gctgcctccccagaggacacccctgagctcagcgcctttttgcgaaactctactattcct
catcttgtcaggaagagggatgtacatgtggtcgaattccacagacagagccctgcaaaa
atactgaattgtacaaatatcgagtgtttacaaatctcctgtgcagtgggacgactcgaa
ggaggagaaagcgcagtcctgaaagtcaggtcacgattatgggcccacaccttcctccag
agaaaaaatgatccctatgctcttgcatccctggtgtcctttgaagttaagaagatgcct
tatacagatcagccagcaaaactcccagaaggaagcatagtaattaagacatcagttatt
tgggcaactccgaatgtttccttctcaatcccattatgggtaataatactagcaatactt
cttggattgttggttctcgccattttaaccttagctttatggaagtgtggattctttgac
agagccagacctcctcaggaggacatgaccgacagggaacagctgacaaatgacaagacc
cctgaggcatga

  All links  
Disease (2)   
   OMIM (2)   
Gene (15)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (16)   
   RefSeq(nuc) (4)   
   GenBank (6)   
   EMBL (6)   
Protein domain (7)   
   Pfam (7)   
All databases (47)   

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