KEGG   Homo sapiens (human): 85441
Entry
85441             CDS       T01001                                 
Symbol
HELZ2, PDIP-1, PRIC285
Name
(RefSeq) helicase with zinc finger 2
  KO
K25165  3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    85441 (HELZ2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.13.1  exoribonuclease II
     85441 (HELZ2)
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     85441 (HELZ2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    Other 3'-5' decay factors
     85441 (HELZ2)
SSDB
Motif
Pfam: AAA_12 AAA_11 RNB AAA_30 AAA_19 AAA_22 UvrD_C_2 ResIII UvrD-helicase nSTAND3 zf-C2H2_jaz SLFN-g3_helicase Viral_helicase1 UvrD_C AAA_24 Bac_DnaA
Other DBs
NCBI-GeneID: 85441
NCBI-ProteinID: NP_001032412
OMIM: 611265
HGNC: 30021
Ensembl: ENSG00000130589
UniProt: Q9BYK8 A0AAA9XBX5
Position
20:complement(63558086..63574239)
AA seq 2649 aa
MAVWEAEQLGGLQRGDLLTPPAPDGDGRTAPLGQPPGAQLYCPACLVTCHSQEAFENHCA
SSEHAQMVAFDQALPWEHRSPPPGLSKFELCPKPDLCEYGDACTKAHSAQELQEWVRRTQ
AVELRGQAAWQDGLVPYQERLLAEYQRSSSEVLVLAETLDGVRVTCNQPLMYQAQERKTQ
YSWTFAVHSEEPLLHVALLKQEPGADFSLVAPGLPPGRLYARGERFRVPSSTADFQVGVR
VQAASFGTFEQWVVFDFGRRPVLLQKLGLQLGQGRRPGPCRNLALGHPEEMERWHTGNRH
VVPGVERTAEQTALMAKYKGPALALEFNRSSVASGPISPTNYRQRMHQFLYEEEAAQQQL
VAKLTLRGQVFLKTALQTPALNMLFAPPGALYAEVPVPSSLMPDTDQGFLLGRAVSTALV
APVPAPDNTVFEVRLERRASSEQALWLLLPARCCLALGLQPEARLVLEVQFQIDPMTFRL
WHQAVDTLPEEQLVVPDLPTCALPRPWSVPPLRRGNRKQELAVALIAGWGPGDGRRVPPL
LIYGPFGTGKTYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATP
LRVMYTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQARELRVPVGF
FSHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFSVARARAAEHTLLHRL
FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
MFCHVAGSPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVS
ALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNT
VLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQVEQGVAQRRR
WPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEALSPASRDITATTAQTE
AAAAPAGDAVKEDVVPGACAAGAAAAAGVESTEAEDAEADFWPWDGELNADDAILRELLD
ESQKVMVTVGEDGLLDTVARPESLQQARLYENLPPAALRKLLHAEPERYRHCSFVPETFE
RASAIPLDDASSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRH
ELAFVCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRVGLERLTAEAR
HSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVL
QKYHTELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDLGPRCEVAVHITDVASFVP
RDGVLDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQL
KSLRFAPSVVQSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHR
LRSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVTPLRWQPAPRS
QQLKALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLASLWKQVQFAARTQDYEQMVD
LVTTDDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYTWATSPIRRYLD
VVLQRQILLALGHGGSAYSARDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDK
LGFVVDVEAGSRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVY
SAQGSSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEKGEASQRRELV
QVQRSHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSPQLWTVAPGFSLCLEHVERPG
DCFSGRVYRAPRDRYRDVDEYACVWEPFCALESATGAVAENDSVTLQHLSVSWEASRTPQ
GQLQGAFRLEAAFLEENCADINFSCCYLCIRLEGLPAPTASPRPGPSSLGPGLNVDPGTY
TWVAHGQTQDWDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPD
LRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGRHKLNPSQNVA
VREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCG
PSNKSVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRS
ITLHHRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCT
CSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNER
LQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHA
GKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAV
LTPYNAQASEISKALRREGIAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSW
LKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVR
VCRRPTMPS
NT seq 7950 nt   +upstreamnt  +downstreamnt
atggctgtgtgggaggccgagcagctgggtggcctccagcggggggacctgctcacaccc
cctgcccctgatggcgacgggcgcacggccccccttggccagccccctggggcccagctg
tactgcccggcctgcttggtcacctgccactctcaggaggccttcgagaaccactgcgca
tcctcggagcacgcacagatggtggccttcgaccaggccctgccctgggagcaccgttcc
ccacccccgggactctccaagttcgagctctgcccaaagcctgacctctgtgagtatggg
gacgcctgcaccaaggcacactcagcacaggagctgcaggagtgggtccggcgcacgcag
gctgtggagctgcgggggcaggcggcctggcaggacgggctggtgccctaccaggagcgg
ctgctggccgagtaccagcgcagcagcagtgaggtccttgtgctggcagagacccttgat
ggagtgcgtgtcacctgcaaccagcccctgatgtaccaggcccaggagaggaagacccag
tacagctggacgtttgccgtccactctgaggagcccctgctacacgtggccctgctgaag
caggagccaggagccgacttctctctggtggctcccggcctcccgccaggccggctctac
gcacggggtgagcgcttccgtgtgcccagctccactgccgacttccaggtgggagtgcgt
gtgcaggctgcctcgttcggcacctttgagcaatgggtggtcttcgactttggccgccgg
ccggtgctgctacaaaagctggggctgcagctgggccaggggcgtcgcccaggaccctgc
aggaatctggcgctcggccaccctgaggagatggagcgctggcacactggcaaccgccac
gtggtgcctggcgtggagcggacggccgagcagacggccctgatggccaagtacaagggc
cctgccctggccctggagttcaaccgcagcagcgtggcctcgggccccatctcaccaacc
aactatcggcagaggatgcaccagtttctctatgaggaggaggcggctcagcagcagctg
gtggccaagctgaccctgcggggccaggtgttcctgaagacggcattgcagacgccagcg
ctgaacatgctcttcgcgcctccgggagcactgtacgcagaggtccccgtcccctcctcc
ctgatgccagacacagaccagggcttcctgctgggccgggcggtcagcacagccctggtg
gcccctgtacctgcacccgacaatacggtgttcgaggtgcggctggagaggcgggccagc
tcagagcaggcgctgtggctgctgcttccggcccgctgctgcttggccctggggctgcag
cctgaggcccgcctggtcctggaggtgcagttccagattgacccgatgaccttccgcctc
tggcaccaggcagtggacacactgcctgaggagcagctggtggtgcccgacttgcccacc
tgcgccctgcccagaccttggtctgtcccacccttgcggcgtggcaaccgcaagcaggag
ctggccgtggcgctcatcgcgggctggggccctggggatgggaggcgtgtccccccgcta
ctcatctatggcccctttggcaccggcaagacctacacgctggccatggcctccctggag
gtcatccggaggcctgaaaccaaggtgctcatctgcacacacaccaacagtgccgccgac
atctacatccgggagtatttccacagccacgtcagcggcggccaccccgaggccactcct
ctccgtgtgatgtacacggaccggccgctgagccagacggacccagtcacgctgcagtac
tgttgcctgaccgacgaccgccaggctttccgcccgcccacacgggcagagctggcgcgg
caccgcgtggtggtcaccaccacctcccaggcccgtgagctcagggtgccggtcggcttc
ttctcccacattctcatcgatgaggcggcccagatgctggagtgcgaggccctcaccccg
ctggcctatgcctcgcacggcacccgcctcgtgctggcgggcgaccacatgcaggtcaca
ccccggctgttcagtgtggccagggcccgggcggccgagcacacgctgctgcaccgcctc
ttcctgtgctaccagcaggagactcacgaggtggcgcggcagagccgcctggtcttccac
gagaactaccgctgcacggacgccattgtcagcttcatctcgcggcacttctacgtggcc
aagggcaaccccatccacgccaggggcaaggttccgccccacccccggcactacccgctc
atgttctgccacgtggcgggcagcccagaccgggacatgtccatggcgtcctggctgaat
ctggctgagattgcgcaggtcgtcgagaaggtgcaggaggcctacaacacctggcccagc
tgctggggcggccgcgagcagaggtgcatctgtgtcgtttcccacggtgcccaggtcagt
gcactgaggcaggagctgaggaggcgggacctaggccaggtgtctgtcggcagttttgag
atcctgccagggcggcagttccgggtcgtggtgctcagcactgtgcacacctgccagagc
ctgctcagccctggggcactggcccctgagttcttcaccgacgcccgcgtgctcaacacc
gtcctgacccgcgcccagtcccagctggtggtagtgggggacgccgtggccctctgctcc
ttcggggcctgcggcaagctctgggagagcttcatccgtgagtgcgtggagcggcacagt
gtctgccccgagggcctgtccatggagcaggtcgagcagggtgtggcgcagagacggcgc
tggcctccccgaggcacacaggctggggcagcggggaactgggaggctgccccagagcca
gtaggggacctggccgaggagcaggcggctgtggtgacggccatggtgaaggcagagccg
ggagatgaggctctgagcccagcatcccgtgacatcacggcaaccacagcgcagacggag
gctgcggcagcaccagcaggagacgcagtgaaggaagacgtggtgcccggggcctgtgcg
gcaggagcggctgctgcagcgggcgtggagtccacggaggctgaggatgcagaggctgac
ttctggccgtgggacggggagctcaacgctgacgacgccatcctacgggagcttctggac
gagagccagaaggtgatggtgaccgtcggggaggacgggctgctggacactgtcgccagg
cccgagtccctgcagcaggcccggctgtacgagaacctgcccccggctgcgctacggaag
ctgctgcacgcggagcccgagcggtaccgccactgctctttcgtgccagagaccttcgag
cgggcgtcagccatcccgctggacgatgcctcctcgggccccatccaggtcaggggccgc
ctggactgtgggatggccttcgccggggatgaggtgctggtgcagctcctttcgggagac
aaggcgcccgaggggcggcttcggggccgcgtgctgggcgtgctgaagaggaagaggcac
gagctggcgtttgtgtgccgcatggacacgtgggacccgcgcatcatggtccccatcaat
ggctccgtgaccaagatcttcgtggccgagctgaaggacccatcgcaggtccccatctac
agcctccggaagggccggctgcagcgtgtggggcttgagaggctcaccgccgaggcccgg
cacagccggctcttctgggtccaaattgtcctgtggcggcaaggcttctactacccgctg
ggcatcgtccgggaggtgctgcctgaggccagcacctgggagcagggcctccgcatcctc
ggcctggagtacagcttgagggtgcccccgtcggaccaggccaccatcaccaaggtgctg
cagaaataccacacggagcttggccgggttgccggccgccgagaggactgccgcgccttc
ttgaccttcactgtggacccccagggcgcctgcaacctcgatgatgccctcagtgtccga
gacctgggtcccaggtgcgaggtggctgtgcacatcactgatgtggccagcttcgtgccc
agggacggggtgctggacgtggaggcgcgaaggcagggcgctgcgttctatgcccccggc
agggagccagtgcccatgctgccggccagcctctgccaggacgtcctcagcctcctgcct
ggccgggaccgcctggccatctccctgttcctcaccatggagaaggccagtggccagctg
aagagcctgcgctttgcaccctccgtggtccagtctgaccgccagctgtcctacgaggag
gcggaggaggtgatcaggcagcacccgggtgccggccgtgagctgccggcccgcctggac
tccgtggacgcctgcgtcgtggccgcgtgctacttctctcggctgctgcgccggcaccgc
ctgcggtccgactgcttctatgagcagccggacgaggacggcaccctgggcttccgcgcg
gcccacatcatggtgaaggagtacatgattcagtttaataggctcgtggctgagttcctg
gtgggcagcgagtgcacgcggacggtcacgcctctgcggtggcagccagcaccccgcagc
cagcagctcaaggccctgtgtgagaagcatggggaccgggtgcccctgtcactgcacctc
ggccaccacctgcacggcggcgggggcagtccccccgacacgcggctgcacctcctggcc
tccctctggaagcaggtccagtttgctgcccgcacccaggactacgaacagatggtggac
ttggtcaccacggacgacatgcacccattcctggctcctgcaggccgcgacctccgcaag
gccctggagcgctcggcgttcggccgctgcgcccggggccaccagcagcagggcggccac
tactcgctgcaggtggactggtacacgtgggccacctcgcccatccgcaggtacctggac
gtggtgttgcagcggcagatcctgctggcgctgggccatgggggctctgcctactctgcc
agggacatcgatgggctctgccaggccttcagcctccagcacgcacttgcccagagctat
cagcggcgggcgcgcagcctgcacctggccgtgcagctcaaggcccagcctctggacaag
ctgggcttcgtggtggacgtggaggcgggctcccgctgcttccggctgctcttccccagc
aaccgggagacgctgcctgacccctgccccgtcccctacggctccctgcagctggccgag
cacccccacgccctggcaggccggccgggcctgcggctcctgtggcggcgccgtgtctac
tcagcgcagggatccagcccgcccctgccactgcctggcactgtgccggacccacacacc
ctggccgtggagacggccctgtggaagcagctgctggagctggtggagctgcagcgctgg
ccggaggcggctgctctcatccaggagaagggcgaggcgtcccagcggcgggagctggtg
caggtgcagcggagccactgtggccatttcctggaggtggcccgggagctgggcagtggg
gacaccctgcaggtgcagctcggcaccagcctgcagcacggcttcctggtaccgagccct
cagctctggacggtggcaccgggcttcagcctctgcctggagcacgtggagcggcccgga
gactgcttctcaggccgtgtgtaccgggccccgagggaccggtaccgcgacgtggatgag
tacgcctgcgtgtgggaaccattctgcgccctggagtcggccaccggcgcggttgccgag
aatgactccgtcacacttcagcacctgagtgtctcctgggaggcgtcacggacgccgcag
gggcagctgcagggcgccttccgcctggaggccgccttcctcgaggagaactgtgccgac
atcaacttcagctgctgctacctctgcatccggctcgaggggctgccggctcccacggcc
agcccacgccctgggcccagcagcctcggccctggcctgaatgttgaccccggcacgtat
acctgggtggcccacgggcagacgcaggactgggaccaggagcgccgggcagaccggcag
gaggctcccagacgggtgcacctcttcgtccaccacatgggcatggagaaggttccggaa
gaggtgctgaggccgggcaccctgttcaccgttgagctgctgcccaagcagcttcctgat
ctccgcaaggaggaagccgtgcgtggactagaggaggcgtccccgctggtcaccagcatc
gcactgggccggcctgtcccgcagcccctctgcagagtgatccccagcaggttcctggag
cggcagacctacaacatccccggaggccgccacaagctgaaccccagccagaacgtggcg
gtcagggaggctctggagaagcctttcacggtcattcagggcccaccaggtacagggaag
acgatcgtgggcctccacatcgtattctggtttcataaatcaaaccaggagcaggtgcag
cccggaggccccccccgtggggagaagcggctggggggtccctgcatcttgtactgcggc
ccctccaacaagtcggtggatgtcctggcaggactgctcctgagaaggatggagctgaag
cccctccgtgtgtacagtgagcaggctgaggccagcgagttcccagtgccgcgtgtgggc
agcaggaagctgctcaggaagagcccccgggaggggaggccgaaccagagcctcaggagc
atcaccctgcaccaccggatccggcaggcccccaacccttactcgtcggaaatcaaggcc
tttgacacccggctgcagagaggggagctcttctccagggaggacctggtctggtacaag
aaggtcttgtgggaggctcggaagttcgagctggaccggcatgaggtcatcctctgcacc
tgctcctgtgcagcctctgccagcctcaaaatcctggacgtgaggcagatccttgttgac
gaggcaggcatggccacggaacctgaaaccctcatccccctggtgcagttcccacaggcc
gagaaggtggttcttctcggagaccacaagcagctgcggcctgtggtcaagaatgagcgg
ctgcaaaacctgggtctggaccggtctctgttcgagcggtaccacgaggacgcacatatg
ctggacactcagtaccgcatgcatgagggcatctgtgccttcccctctgtggcgttctac
aagagcaagctgaagacgtggcagggcctgaggaggccgcccagtgtcctgggccacgct
ggcaaggagagctgccctgtcatctttggccacgtgcagggccacgagcggagcctgctg
gtgtccacggacgaagggaatgagaactccaaggccaacctggaggaggtggctgaggtg
gtccgtatcaccaagcagctgaccctggggaggaccgtagagccccaggacatcgccgtc
ctcacgccctacaacgcgcaggcctctgagatcagcaaggcccttcggcgagagggcatc
gccggggtggccgtgtcctccatcaccaagagccaggggagcgagtggcgctatgtgctg
gtgagcaccgtccgcacctgtgccaagagcgacctggaccagcggcccaccaagagctgg
ctcaagaagtttctgggcttcgttgtggaccccaaccaagtgaatgtggctgtcacgcgg
gcccaggaggggctctgcctgatcggagaccacctccttctgcgctgctgccccctctgg
cgtagcctcctggacttctgcgaggctcagcagaccctcgtgcctgccggccaggtgcgc
gtctgcaggaggccaactatgccttcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (62)   
   KEGG ORTHOLOGY (1)   
   RefGene (49)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
   PHAROS (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (34)   
   RefSeq(nuc) (4)   
   GenBank (15)   
   EMBL (15)   
Protein domain (16)   
   Pfam (16)   
All databases (126)   

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