KEGG   Homo sapiens (human): 8569Help
Entry
8569              CDS       T01001                                 

Gene name
MKNK1, MNK1
Definition
(RefSeq) MAPK interacting serine/threonine kinase 1
  KO
K04372  MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04910  Insulin signaling pathway
Drug target
Tomivosertib (DG03019): D11452 D11481
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    8569 (MKNK1)
   04066 HIF-1 signaling pathway
    8569 (MKNK1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    8569 (MKNK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8569 (MKNK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     8569 (MKNK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   8569 (MKNK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH zf-RRN7
Motif
Other DBs
NCBI-GeneID: 8569
NCBI-ProteinID: NP_003675
OMIM: 606724
HGNC: 7110
Ensembl: ENSG00000079277
Vega: OTTHUMG00000007983
Pharos: Q9BUB5(Tchem)
UniProt: Q9BUB5
Structure
PDB: 

Position
1p33
AA seq 453 aa AA seqDB search
MGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNG
KEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSI
LAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSS
DPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE
LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWD
RGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHP
WVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLC
SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
NT seq 1362 nt NT seq  +upstreamnt  +downstreamnt
atgggcagtagcgaaccccttcccatcgcagatggtgacaggaggaggaagaagaagcgg
aggggccgggccactgactccttgccaggaaagtttgaagatatgtacaagctgacctct
gaattgcttggagagggagcctatgccaaagttcaaggtgccgtgagcctacagaatggc
aaagagtatgccgtcaaaatcatcgagaaacaagcagggcacagtcggagtagggtgttt
cgagaggtggagacgctgtatcagtgtcagggaaacaagaacattttggagctgattgag
ttctttgaagatgacacaaggttttacttggtctttgagaaattgcaaggaggttccatc
ttagcccacatccagaagcaaaagcacttcaatgagcgagaagccagccgagtggtgcgg
gacgttgctgctgcccttgacttcctgcataccaaagacaaagtctctctctgtcaccta
ggctggagtgctatggcgccatcagggctcactgcagccccaacctccctgggctccagt
gatcctcccacctcagcctcccaagtagctgggactacaggcattgctcatcgtgatctg
aaaccagaaaatatattgtgtgaatctccagaaaaggtgtctccagtgaaaatctgtgac
tttgacttgggcagtgggatgaaactgaacaactcctgtacccccataaccacaccagag
ctgaccaccccatgtggctctgcagaatacatggcccctgaggtagtggaggtcttcacg
gaccaggccacattctacgacaagcgctgtgacctgtggagcctgggcgtggtcctctac
atcatgctgagtggctacccacccttcgtgggtcactgcggggccgactgtggctgggac
cggggcgaggtctgcagggtgtgccagaacaagctgtttgaaagcatccaggaaggcaag
tatgagtttcctgacaaggactgggcacacatctccagtgaagccaaagacctcatctcc
aagctcctggtgcgagatgcaaagcagagacttagcgccgcccaagttctgcagcaccca
tgggtgcaggggcaagctccagaaaagggactccccacgccgcaagtcctccagaggaac
agcagcacaatggacctgacgctcttcgcagctgaggccatcgcccttaaccgccagcta
tctcagcacgaagagaacgaactagcagaggagccagaggcactagctgatggcctctgc
tccatgaagctttcccctccctgcaagtcacgcctggcccggagacgggccctggcccag
gcaggccgtggtgaagacaggagcccgcccacagcactctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (26)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (66)   
   RefSeq(nuc) (28)   
   GenBank (19)   
   EMBL (19)   
Protein domain (4)   
   Pfam (4)   
All databases (143)   

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